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ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 Proteins (ABCB4)

The membrane-associated protein encoded by ABCB4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 Antibodies (64) and ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ABCB4 18671 P21447
ABCB4 5244 P21439
Rat ABCB4 ABCB4 24891 Q08201
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Top ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 Proteins at antibodies-online.com

Showing 8 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details
Yeast Mouse His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Mouse GST tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
Yeast REACT_Entamoeba histolytica His tag   1 mg Log in to see 56 to 66 Days
$2,218.33
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   50 μg Log in to see 16 to 21 Days
$314.29
Details

ABCB4 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , ,
, ,
Human ,
,

More Proteins for ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 (ABCB4) Interaction Partners

Zebrafish ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 (ABCB4) interaction partners

  1. Zebrafish Abcb4 plays crucial roles in cellular efflux of microcystin-LR and is a potential molecular marker for the monitoring of cyanobacteria contamination in the aquatic environment.

Rabbit ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 (ABCB4) interaction partners

  1. In the rabbit cornea, the expression and activity of MDR1 transporter was confirmed, whereas human cell culture models and porcine corneas did not show MDR1 expression

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 (ABCB4) interaction partners

  1. Analysis regulator effects analysis, showed that curcumin's antiinflammatory activity in Mdr1a(-/-) mouse colon may be mediated by activation of alpha-catenin (show CTNNA1 Proteins), which has not previously been reported

  2. mdr1a-siRNA mediated inhibition of Mdr1a expression markedly elevates serum levels and increases the hepatic exposure to triptolide.

  3. Data suggest that activities of human ABCB1 (show ABCB1 Proteins) and mouse Abcb1a/Mdr1a are unaltered (that is, efflux of fluorescent dyes is unaltered) in chimeric forms created by exchange of homologous transmembrane/nucleotide-binding domains of ABCB1 (show ABCB1 Proteins) and Abcb1a/Mdr1a.

  4. Findings imply a close link between Mdr2 (-/-) -associated tumorigenesis and perturbation of these biological processes and suggest potential extrahepatic functions of Mdr2.

  5. Sterols may interact with Pgp and modulate its structure and function by occupying part of the drug-binding pocket or by binding to putative consensus cholesterol-binding (CRAC/CARC) motifs located within the transmembrane domains.

  6. compromised Mrp3 function can enhance injury in the gastrointestinal tract after Diclofenac treatment

  7. Equilibrated Pgp has a considerably different electrostatic profile compared to Sav1866 that implicates significant kinetic and thermodynamic differences in transport mechanisms

  8. The antifibrotic effects of rapamycin, everolimus, captopril and irbesartan seen in other models of fibrosis were not replicated in the Mdr2(-/-) model of liver fibrosis.

  9. Mdr1a participates in the elimination of paraquat from the kidneys and protects against subsequent toxicity.

  10. Data show that mammary tumors resembling BRCA1 (show BRCA1 Proteins)-associated metaplastic breast carcinoma display intrinsic resistance to the poly(ADP-ribose) polymerase (PARP (show PARP1 Proteins)) inhibitor olaparib as a result of increased P-glycoprotein drug efflux transporter expression.

Human ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 (ABCB4) interaction partners

  1. There are varying effects of ABCB4 missense mutations but even a modest reduction in MDR3 activity may contribute or predispose to the onset of Cholestatic liver disease in the pediatric age.

  2. A mutation of ABCB4 protein as a cause of liver disease

  3. most severe phenotypes appreciated by the duration of transplant-free survival were caused by ABCB4 variants that were markedly retained in the endoplasmic reticulum and expressed in a homozygous status

  4. Report highly specific expression of BSEP (show ABCB11 Proteins) and MDR3 in hepatocellular carcinoma.

  5. Interaction of ABCB4 with EBP50 (show SLC9A3R1 Proteins) through its PDZ-like motif plays a critical role in the regulation of ABCB4 expression and stability at the canalicular plasma membrane.

  6. Case Report: liver fibrosis associated with MDR3 deficiency can be reversed by long-term treatment with UDCA, at least when there is residual expression of the protein.

  7. These results suggest that a SM-rich membrane environment is required for ABCB4 to function.

  8. The exome-sequencing of 3 family members identified 7 potential mutations: of these, rs58238559, a rare missense genetic variant in the ABCB4 gene was carried by all affected members; rs58238559 in ABCB4 is a rare missense variant with a significant effect on the development of atrial flutter or atrial fibrillation.

  9. variants in the genes ABCB4, TP53AIP1, ARHGAP32 and TMEM88B were identified linked to the alexithymia phenotype.

  10. ABCB4 is a frequently silenced gene in different cancers and it may act tumor suppressivly in lung cancer.

ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 (ABCB4) Protein Profile

Protein Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined\; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function.

Gene names and symbols associated with ABCB4

  • ATP-binding cassette, sub-family B (MDR/TAP), member 5 (abcb5)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1-like B (ABCB1LB)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1-like A (ABCB1LA)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 4 (ABCB4)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 4 (abcb4)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1A (Abcb1a)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1B (Abcb1b)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 4 (Abcb4)
  • ATP-binding cassette, subfamily B (MDR/TAP), member 4 (Abcb4)
  • ABC20 protein
  • ABC21 protein
  • ABCB1 protein
  • Abcb4 protein
  • ABCB4a protein
  • CMDR1 protein
  • Evi32 protein
  • GBD1 protein
  • GP170 protein
  • ICP3 protein
  • mdr-2 protein
  • mdr-3 protein
  • MDR1 protein
  • Mdr1a protein
  • Mdr2 protein
  • MDR2/3 protein
  • MDR3 protein
  • P-gp protein
  • PFIC-3 protein
  • Pgp protein
  • PGP2 protein
  • PGP3 protein
  • Pgy-2 protein
  • Pgy-3 protein
  • PGY1 protein
  • Pgy2 protein
  • Pgy3 protein
  • zgc:172149 protein

Protein level used designations for ABCB4

ATP-binding cassette, sub-family B (MDR/TAP), member 4 , ATP-binding cassette, subfamily B, member 4 , ABC transporter protein , ATP-binding cassette, sub-family B (MDR/TAP), member 1 , ATP-binding cassette, subfamily B, member 1 , member 1 , member 4 , multidrug resistance protein 1 , sub-family B (MDR/TAP) , subfamily B , P glycoprotein 3/ multiple drug resistance 3 , ABC efflux transporter 4 , abcb1b , multidrug resistance protein 3-like , multidrug resistance protein 3 , ATP-binding cassette transporter protein , multi-drug resistance P-glycoprotein 1 , ATP-binding cassette sub-family B member 1A , ATP-binding cassette, subfamily B, member 1A , P glycoprotein 3 , P-glycoprotein 3 , ecotropic viral integration site 32 , multi-drug resistance 3 , multidrug resistance protein 1A , multiple drug resistant 1a , P-glycoprotein 2 , multidrug resistance protein 2 , ATP-binding cassette sub-family B member 4 , P glycoprotein 3/multiple drug resistance 3 , P-glycoprotein-3/multiple drug resistance-3 , multiple drug resistance 3 , P glycoprotein 2 , multidrug resistance 3 , p-glycoprotein isoform III , ATP-binding cassette sub-family B (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug resistance 2 , ATP-binding cassette sub-family B (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug resistance 2) , ATP-binding cassette, sub-family B (MDR/TAP), member 4 (P-glycoprotein 3/ multidrug resistance 2) , P-glycoprotein 3/ multidrug resistance 2

GENE ID SPECIES
394865 Xenopus (Silurana) tropicalis
395712 Gallus gallus
420534 Gallus gallus
748364 Pan troglodytes
756756 Strongylocentrotus purpuratus
783154 Bos taurus
100136865 Danio rerio
100354947 Oryctolagus cuniculus
100398854 Callithrix jacchus
100455534 Pongo abelii
100462975 Monodelphis domestica
100475375 Ailuropoda melanoleuca
100008914 Oryctolagus cuniculus
18671 Mus musculus
100682537 Cricetulus griseus
5244 Homo sapiens
18670 Mus musculus
482284 Canis lupus familiaris
100144586 Sus scrofa
100336338 Bos taurus
100682535 Cricetulus griseus
24891 Rattus norvegicus
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