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ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 6 Proteins (ABCB6)

The membrane-associated protein encoded by ABCB6 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 6 Antibodies (62) and ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 6 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ABCB6 10058 Q9NP58
ABCB6 74104 Q9DC29
Rat ABCB6 ABCB6 140669 O70595
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Top ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 6 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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ABCB6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 6 (ABCB6) Interaction Partners

Human ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 6 (ABCB6) interaction partners

  1. genetic variants linked to lower or absent cell surface expression of ABCB6/Langereis may be more common than previously thought.

  2. These data indicate that the expression of ABCB6 in plasma membrane is important for porphyrin accumulation after ALA administration, including hypoxic conditions.

  3. Identified two novel ABCB6 mutations in two Chinese families affected with dyschromatosis universalis hereditaria (DUH), underscoring the causative role of the ABCB6 mutations in the molecular pathogenesis of DUH.

  4. Data suggest N-terminal transmembrane domain of ABCB6 functions as independent folding unit and plays crucial role in lysosomal (rather than plasma membrane) targeting of ABCB6; this domain is dispensable for dimerization and ATP binding/hydrolysis.

  5. a heterozygous substitution Arg723Gln in the ATP-binding cassette, Subfamily B, Member 6 protein that segregated with FP in the Cardiff family and was also present in both blood donors. Arg723Gln is listed in human variation databases

  6. Data indicate ATP-binding cassette sub-family B member 6 (ABCB6) as the disease candidate gene by discovering a coding mutation (c.1358C>T; p.Ala453Val) that co-segregates with the dyschromatosis universalis hereditaria phenotype.

  7. Expression of ABCB6 is related to resistance to 5-FU, SN-38 and vincristine.

  8. We describe eight new mutations in ABCB6 of which seven, including three missense mutations, underlie the Lan (show DGS2 Proteins)- phenotype and determine that a complete gene deletion of ABCG2 or ABCB6 is not responsible for the Jr(a-) or Lan (show DGS2 Proteins)- phenotype, respectively.

  9. High expression levels of ABCB6 are associated with glioma.

  10. data add new variants to the repertoire of ABCB6 mutations with dyschromatosis universalis hereditaria.

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 6 (ABCB6) interaction partners

  1. liver extracts from Abcb6-deficient mice suppress P450 (show POR Proteins) expression in human primary hepatocytes, suggest that this mouse model may provide an opportunity to understand the physiological signals and the mechanisms involved in negative regulation of P450s

  2. Identify a new role of ABCB6 in preventing atherosclerosis development by dampening platelet production, reactivity, and chemokine (C-C motif) ligand 5 (show CCL5 Proteins) deposition in atherosclerotic lesions.

  3. Polycyclic aromatic hydrocarbons (PAHs) mediate transcriptional activation of the ATP binding cassette transporter (show ABCC3 Proteins) ABCB6 gene via the aryl hydrocarbon receptor (AhR (show AHR Proteins))

  4. Abcb6 is the sole ATP-dependent porphyrin importer, and loss of Abcb6 produces up-regulation of heme and iron pathways necessary for normal development.

  5. Conserved intramolecular disulfide bond is critical to trafficking and fate of ATP-binding cassette (ABC) transporters ABCB6 and sulfonylurea receptor 1 (SUR1)/ABCC8 (show ABCC8 Proteins).

  6. ABCB6 is uniquely located in the outer mitochondrial membrane and is required for mitochondrial porphyrin uptake

ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 6 (ABCB6) Protein Profile

Protein Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This half-transporter likely plays a role in mitochondrial function. Localized to 2q26, this gene is considered a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function.

Gene names and symbols associated with ABCB6

  • ATP-binding cassette, sub-family B (MDR/TAP), member 6 (ABCB6)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 6a (abcb6a)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 6 (abcb6)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Abcb6)
  • ATP-binding cassette, subfamily B (MDR/TAP), member 6 (Abcb6)
  • autophagy related 9A (ATG9A)
  • 1200005B17Rik protein
  • ABC protein
  • ABC14 protein
  • abcb6 protein
  • LAN protein
  • MCOPCB7 protein
  • MTABC3 protein
  • PRP protein
  • umat protein

Protein level used designations for ABCB6

ATP-binding cassette, sub-family B (MDR/TAP), member 6 , ATP-binding cassette sub-family B member 6, mitochondrial , ATP-binding cassette, sub-family B, member 6 , ATP-binding cassette sub-family B member 6, mitochondrial-like , ATP-binding cassette half-transporter , P-glycoprotein-related protein , mitochondrial ABC transporter 3 , mt-ABC transporter 3 , ubiquitously-expressed mammalian ABC half transporter , ATG9 autophagy related 9 homolog A

GENE ID SPECIES
100059171 Equus caballus
425721 Gallus gallus
459959 Pan troglodytes
564067 Danio rerio
780100 Xenopus (Silurana) tropicalis
100410342 Callithrix jacchus
100444435 Pongo abelii
10058 Homo sapiens
74104 Mus musculus
783257 Bos taurus
100722513 Cavia porcellus
140669 Rattus norvegicus
478914 Canis lupus familiaris
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