anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Antibodies

The membrane-associated protein encoded by ABCB1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Kits (21) and ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ABCB1 5243 P08183
ABCB1 170913  
ABCB1 18669 P06795
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Top anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Antibodies at antibodies-online.com

Showing 10 out of 280 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB <b>WB Suggested Anti-ABCB1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>NCI-H226 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot using affinity purified anti-ABCB1 antibody shows detection of ABCB1 in crude membrane extracts from HF insect cells over-expressing human ABCB1. The extract was loaded onto a gel in the amounts indicated followed by electrophoresis and transfer to nitrocellulose. The membrane was probed with the primary antibody diluted to 1:600, followed by Peroxidase Conjugated Affinity Purified Anti-RABBIT IgG at 1:10,000. 25 μL Log in to see 1 to 2 Days
$139.00
Details
Human Rabbit Un-conjugated IHC (fro), IHC (p) Anti-P Glycoprotein Picoband antibody,  IHC(P): Mouse Kidney Tissue Anti-P Glycoprotein Picoband antibody,  IHC(F): Rat Kidney Tissue 100 μg Log in to see 4 to 6 Days
$200.00
Details
Dog Rabbit Un-conjugated EIA, WB   0.1 mg Log in to see 12 to 15 Days
$450.34
Details
Human Mouse Un-conjugated ELISA, WB 100 μg Log in to see 2 to 3 Days
$430.10
Details
Human Mouse Un-conjugated IHC (fro), IF, IHC (p), WB   0.1 mg Log in to see 6 to 8 Days
$313.50
Details
Human Mouse Un-conjugated IHC (p), WB Human Vessel: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 7 to 9 Days
$451.00
Details
Human Rabbit Un-conjugated IHC (p) Anti-ABCB1 / MDR1 antibody  ABIN1048283 IHC staining of human kidney, proximal convoluted tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 7 to 9 Days
$451.00
Details
Hamster Rabbit Un-conjugated IHC (p), WB Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 7 to 9 Days
$676.50
Details
Human Mouse Un-conjugated FACS, IHC (fro), IF, IHC (p), IP   0.1 mg Log in to see 6 to 8 Days
$346.50
Details

ABCB1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Antibodies

  1. Human Polyclonal ABCB1 Primary Antibody for IHC (fro), IHC (p) - ABIN3043967 : Gao, Liu, Wang, Lin, Zhang: Effects of Lewis Y antigen on the gene expression of multiple drug resistance-associated proteins in human ovarian cancer RMG-I-H cells. in Medical oncology (Northwood, London, England) 2010 (PubMed)
    Show all 2 Pubmed References

  2. Human Monoclonal ABCB1 Primary Antibody for ICC, IHC (fro) - ABIN3043101 : Wang, Deng, Lu, Xu, Yan, Ye, Chen et al.: Gambogic acid as a non-competitive inhibitor of ATP-binding cassette transporter B1 reverses the multidrug resistance of human epithelial cancers by promoting ATP-binding cassette transporter B1 ... in Basic & clinical pharmacology & toxicology 2012 (PubMed)
    Show all 2 Pubmed References

  3. Human Monoclonal ABCB1 Primary Antibody for ELISA, WB - ABIN1724923 : Zhang, Wang, Cai, Jiang, Zhou, Yang, Chen, Chen, Dou: Downregulation of gene MDR1 by shRNA to reverse multidrug-resistance of ovarian cancer A2780 cells. in Journal of cancer research and therapeutics 2012 (PubMed)
    Show all 2 Pubmed References

  4. Human Monoclonal ABCB1 Primary Antibody for ELISA, WB - ABIN1724927 : Rubi?, Ho?ysz, Barczak, Gryczka, ?aci?ski, Jagielski, Czernikiewicz, Pó?rolniczak, Wojewoda, Perz, Bia?ek, Morze, Kandu?a, Lisiak, Mrozikiewicz, Grodecka-Gazdecka, Rybczy?ska: Study of ABCB1 polymorphism frequency in breast cancer patients from Poland. in Pharmacological reports : PR 2013 (PubMed)
    Show all 2 Pubmed References

  5. Human Polyclonal ABCB1 Primary Antibody for IHC, IHC (p) - ABIN4333368 : Bernstein, Hölzl, Dobrowolny, Hildebrandt, Trübner, Krohn, Bogerts, Pahnke: Vascular and extravascular distribution of the ATP-binding cassette transporters ABCB1 and ABCC1 in aged human brain and pituitary. in Mechanisms of ageing and development 2015 (PubMed)
    Show all 2 Pubmed References

  6. Human Monoclonal ABCB1 Primary Antibody for FACS - ABIN2479421 : Mechetner, Roninson: Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody. in Proceedings of the National Academy of Sciences of the United States of America 1992 (PubMed)
    Show all 4 Pubmed References

  7. Human Monoclonal ABCB1 Primary Antibody for FACS - ABIN2479422 : Beck, Grogan, Willman, Cordon-Cardo, Parham, Kuttesch, Andreeff, Bates, Berard, Boyett, Brophy, Broxterman, Chan, Dalton, Dietel, Fojo, Gascoyne, Head, Houghton, Srivastava, Lehnert, Leith, Paietta et al.: Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations. ... in Cancer research 1996 (PubMed)
    Show all 4 Pubmed References

  8. Human Monoclonal ABCB1 Primary Antibody for IHC (fro), FACS - ABIN2479419 : Koziolek, Riess, Geiger, Thévenod, Hauser: Expression of multidrug resistance P-glycoprotein in kidney allografts from cyclosporine A-treated patients. in Kidney international 2001 (PubMed)
    Show all 4 Pubmed References

  9. Human Monoclonal ABCB1 Primary Antibody for FACS - ABIN2479424 : Park, Lomri, Simeoni, Fruehauf, Mechetner: Analysis of P-glycoprotein-mediated membrane transport in human peripheral blood lymphocytes using the UIC2 shift assay. in Cytometry. Part A : the journal of the International Society for Analytical Cytology 2003 (PubMed)
    Show all 4 Pubmed References

  10. Hamster Monoclonal ABCB1 Primary Antibody for FACS, ICC - ABIN4333365 : Kurihara, Sato, Akimoto, Ogura, Ito: Identification and characterization of ABCB1-mediated and non-apoptotic sebum secretion in differentiated hamster sebocytes. in Biochimica et biophysica acta 2011 (PubMed)

More Antibodies against ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Interaction Partners

Cow (Bovine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) interaction partners

  1. P-gp (show ABCB4 Antibodies), Bcrp (show ABCG2 Antibodies) and Mrp1 (show ABCC1 Antibodies) are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.

  2. This study has, for the first time, confirmed the expression of ABCB1 in epithelial cells of the bovine rumen.

  3. Bovine blastocysts stimulated by the combined treatment with forskolin, rifampicin, and interferon-alpha to express high levels of ATP-binding cassette subfamily B member 1 displayed better freezing resistance

  4. ABCB1 is expressed in bovine oocytes and embryos.

Human ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) interaction partners

  1. we review the emerging role of molecular dynamics simulation techniques in our understanding of the membrane-embedded conformation of P-gp (show ABCB4 Antibodies)--{REVIEW}

  2. Studied ABCB1 protein expression immunohistochemically in twelve human post-mortem brain regions known to play a role in schizophrenia, in 13 patients with schizophrenia and nine controls; found a significantly reduced density of ABCB1-expressing neurons in the left habenula.

  3. Using an integrated pathway-based approach, we identified polymorphisms in ABCC6 (show ABCC6 Antibodies), ABCB1 and CYP2C8 (show CYP2C8 Antibodies) associated with overall survival. These associations were replicated in a large independent cohort, highlighting the importance of pharmacokinetic genes as prognostic markers in Ewing sarcoma

  4. The authors found that transient TUBB3 (show TUBB3 Antibodies) activation, through ABCB1, in response to the stimulation of FOXO3a (show FOXO3 Antibodies) expression, significantly contributes to the cross-resistance of the paclitaxel-resistant cell population and consequently limits the efficacy of both agents where cancer cells have developed multiple resistance.

  5. MDR1 (show TBC1D9 Antibodies) and CYP3A5 (show CYP3A5 Antibodies) genetic polymorphisms significantly influence plasma trough levels and therapeutic response of imatinib in patients with chronic myeloid leukemia (show BCL11A Antibodies). Patients with GG genotype for CYP3A5 (show CYP3A5 Antibodies)-A6986G (P=0.016) and TT genotype for MDR1 (show TBC1D9 Antibodies)-C3435T (P=0.013) polymorphisms had significantly higher trough levels of imatinib.

  6. Rescue experiments confirmed the combined role of LUCAT1, miR (show MLXIP Antibodies)-200c and ABCB1 on osteosarcoma proliferation, invasion and methotrexate resistance. Overall, results indicate the vital role of LUCAT1 in the methotrexate resistance regulation through miR (show MLXIP Antibodies)-200c/ABCB1 pathway, providing a novel insight and treatment strategy for osteosarcoma drug resistance.

  7. Mdr1 (show TBC1D9 Antibodies) enforces T Cell homeostasis in the presence of intestinal bile acids.

  8. Data show that co-treated with vincristine and XL019, a inhibitor of JAK2 and P-glycoprotein (P-gp), up-regulated expression of p21 and phosphorylated H2A histone family, member X (pH2AX).

  9. Tangeretin could sensitize ABCB1-overexpressing cancer cells to chemotherapeutical agents by directly inhibiting ABCB1 transporter function.

  10. over-functional P-gp (show ABCB4 Antibodies) might play an important role in the pathogenesis of ITP (show ITPA Antibodies) and induce GCs (show GCLC Antibodies) resistance in nonresponsive ITP (show ITPA Antibodies) patients. The blockage of P-gp (show ABCB4 Antibodies) could be a promising therapeutic approach for GCs (show GCLC Antibodies)-resistant patients with ITP (show ITPA Antibodies).

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) interaction partners

  1. conclusion, MDR1 (show ABCB4 Antibodies) and BCRP (show ABCG2 Antibodies) are expressed on apical membranes of the rodent placental SynT (show STX1A Antibodies)-II layer.

  2. Mdr1 (show ABCB4 Antibodies) enforces T Cell homeostasis in the presence of intestinal bile acids.

  3. Loss of ABCB1 expression is associated with neonatal hyperbilirubinemia.

  4. the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp (show ABCB4 Antibodies) ATPase (show DNAH8 Antibodies) activity

  5. Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.

  6. Chrysosplenetin inhibited P-gp (show ABCB4 Antibodies) activity and reverse the up-regulated P-gp (show ABCB4 Antibodies) and MDR1 (show ABCB4 Antibodies) levels induced by artemisinin.

  7. Tamsulosin and tolterodine with P-gp (show ABCB4 Antibodies) gene expression and activity in an enantiomer-specific way.

  8. Pgp (show ABCB4 Antibodies)-coupled ATPase (show DNAH8 Antibodies) activity kinetics measured with a range of verapamil and digoxin concentrations fit well to a DDI model encompassing non-competitive and competitive inhibition of digoxin by verapamil.

  9. Data show that human transgenic mutant huntingtin (show HTT Antibodies) (mHtt) aggregation might be regulated by multidrug resistance protein 1 (MDR1 (show ABCB4 Antibodies)) which suggests that MDR1 (show ABCB4 Antibodies) might be a potential therapeutic target for Huntington's disease.

  10. In vitro and in vivo downregulation of the ATP binding cassette transporter (show ABCC3 Antibodies) B1 by the HMG-CoA reductase (show HMGCR Antibodies) inhibitor simvastatin

ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Antigen Profile

Protein Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Gene names and symbols associated with ABCB1

  • ATP binding cassette subfamily B member 1 (ABCB1) antibody
  • ATP binding cassette subfamily B member 1 L homeolog (abcb1.L) antibody
  • ATP binding cassette subfamily B member 1A (Abcb1a) antibody
  • ATP binding cassette subfamily B member 1 (Abcb1) antibody
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1B (Abcb1b) antibody
  • ATP-binding cassette, subfamily B (MDR/TAP), member 1B (Abcb1b) antibody
  • malic enzyme complex, mitochondrial (Mod2) antibody
  • ABC20 antibody
  • ABCB1 antibody
  • Cd243 antibody
  • CLCS antibody
  • GP170 antibody
  • Mdr antibody
  • Mdr-1 antibody
  • Mdr1 antibody
  • Mdr1a antibody
  • Mdr1b antibody
  • Mod-2 antibody
  • Mod-2r antibody
  • Mod-2s antibody
  • Mod2-r antibody
  • Mod2-s antibody
  • p-gp antibody
  • PGP1 antibody
  • Pgy-1 antibody
  • Pgy1 antibody
  • xemdr antibody

Protein level used designations for ABCB1

bovine P-glycoprotein , multidrug resistance protein 1 , multidrug resistance protein , ATP-binding cassette sub-family B member 1 , P-glycoprotein 1 , colchicin sensitivity , doxorubicin resistance , ATP-binding cassette, subfamily B, member 1 , P-glycoprotein , multidrug resistance p-glycoprotein , ATP-binding cassette, sub-family B (MDR/TAP), member 1 , ATP-binding cassette, subfamily B (MDR/TAP), member 1A , multiple drug resistant 1a , P glycoprotein 1 , multidrug resistance protein 1B , ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1) , ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1) , ATP-binding cassette, sub-family B (MDR/TAP), member 1B , ATP-binding cassette, subfamily B, member 1B , P-glycoprotein/multidrug resistance 1 , malic enzyme complex, mitochondrial , malic enzyme, mitochondrial regulatory , malic enzyme, mitochondrial structural

GENE ID SPECIES
281585 Bos taurus
397812 Xenopus laevis
463516 Pan troglodytes
5243 Homo sapiens
403879 Canis lupus familiaris
170913 Rattus norvegicus
100682536 Cricetulus griseus
18669 Mus musculus
24646 Rattus norvegicus
110357 Mus musculus
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