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ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 Proteins (ABCC1)

The protein encoded by ABCC1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ABCC1 Antibodies (52) and ABCC1 Kits (22) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ABCC1 4363 P33527
ABCC1 17250 O35379
Rat ABCC1 ABCC1 24565 Q8CG09
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Top ABCC1 Proteins at antibodies-online.com

Showing 7 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$897.60
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 16 Days
$928.13
Details

ABCC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
, ,

More Proteins for ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 (ABCC1) Interaction Partners

Human ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 (ABCC1) interaction partners

  1. Taxus chinensis var.-mediated downregulation of MRP1 (show MDM4 Proteins), MDR1, and LRP (show RPSA Proteins) might contribute to the reversal of drug resistance in non-small cell lung cancer stem cells.

  2. miR (show MLXIP Proteins)-145 accelerated MRP1 (show MDM4 Proteins) mRNA degradation by directly targeting its 3'-UTR and therefore caused increased cisplatin toxicity in gallbladder cancer cells. Lower miR (show MLXIP Proteins)-145 and higher MRP1 (show MDM4 Proteins) expression levels predicted poor prognosis in GBC patients who received chemotherapy.

  3. Caveolin-1 (show CAV1 Proteins) affects ESCC MDR by regulating the expressions of P-gp (show ABCB4 Proteins) and MRP1 (show MDM4 Proteins).

  4. Report ABCC1 induction by genistein in breast cancer cells may result in drug resistance in tumors treated with substrates of this transport.

  5. Results suggest that the LRIG1could negatively control MRP-1 (show MDM4 Proteins) and the apoptosis to improve the sensitivity of VP16-related chemotherapy.

  6. Data, including data from studies in knockout mice, suggest that MRP1 (show MDM4 Proteins) is involved in development of vascular endothelial dysfunction in diabetic angiopathy; MRP1 (show MDM4 Proteins) appears to be required for oxidative stress in endothelial cells due to hyperglycemia.

  7. The expression of ABCB1 (show ABCB1 Proteins), ABCC1 and ABCG2 on primary human T-cells correlates with the efficacy of JAK (show JAK3 Proteins) inhibitor ruxolitinib treatment in regard to T-cell activation and proliferation.

  8. Positive expressions of MRP and TOP2A (show TOP2A Proteins) in the tumor tissue are associated with increased risk of developing brain metastases in non-small cell lung cancer (NSCLC).

  9. the expression and localization of the ATP-Binding Cassette (ABC (show ABCB6 Proteins)) transporters BCRP (ABCG2), P-gp (ABCB1 (show ABCB4 Proteins)) and MRP1 (ABCC1) in human umbilical cords, is reported.

  10. Report decreased function MRP1 (show MDM4 Proteins) activity in methotrexate treated rheumatoid arthritis patients.

Mouse (Murine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 (ABCC1) interaction partners

  1. Data, including data from studies in knockout mice, suggest that Mrp1 is involved in development of vascular endothelial dysfunction in diabetic angiopathy; Mrp1 appears to be required for oxidative stress in endothelial cells due to hyperglycemia.

  2. Oxidant-enriched Tumorigenic Endothelial Cells (EOMA) cells survive a heavy oxidant burden by rapid efflux of GSSG, which is lethal if trapped within the cell. A hyperactive MRP-1 system for GSSG efflux acts as a critical survival factor for these cells, making it a potential target for EOMA therapeutics.

  3. P-gp, Bcrp, Mrp1 and Mrp4 are differentially expressed at the outer and inner blood retinal barrier, resulting in an altered ability to limit substrate distribution at the retina as compared with the blood brain barrier

  4. Lentivirus-based RNAi stably knocks down the expression of the Mrp1 gene in the established TM4 (show TPM4 Proteins) sertoli cell line.

  5. neprilysin (show MME Proteins) x ABCC1 double-deficient mice present a new model for early effects of amyloid-beta-related mild cognitive impairment that allows investigations without artificial overexpression of inherited Alzheimer's disease genes

  6. Expression of apoA-I (show APOA1 Proteins) or ABCA1 (show ABCA1 Proteins) can reduce steatosis by decreasing lipid storage in hepatocytes through lipid transport and may also reduce endoplasmic reticulum stress, further lessening hepatic steatosis

  7. Loss of Mrp1 coupled with reductions in steroid hormone levels leads to alterations in extrahepatic phase I, phase II and phase III metabolizing enzymes in a tissue-specific manner.

  8. Cd or H(2)O(2) exposure increased the expression of key transport genes, Mrp1 and Mrp2 (show ABCC2 Proteins), in WT cells but not in metallothionein (show MT Proteins)-null cells.

  9. These results identify Mrp1 as the transporter essential for S1P (show S1PR1 Proteins) efflux from the endothelial cells and thus for inside-out S1P (show S1PR1 Proteins) signaling to P-glycoprotein at the blood-brain and blood-spinal cord barriers.

  10. investigated changes in the expression and activity of multidrug resistance protein 1 and multidrug resistance-associated protein 1 in highly purified lung dendritic cells during aging

Cow (Bovine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 (ABCC1) interaction partners

  1. P-gp (show ABCB4 Proteins), Bcrp and Mrp1 are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.

ABCC1 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown.

Gene names and symbols associated with ABCC1

  • ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (ABCC1)
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (Abcc1)
  • ATP-binding cassette, subfamily C (CFTR/MRP), member 1 (Abcc1)
  • ABC29 protein
  • ABCC protein
  • Abcc1a protein
  • Abcc1b protein
  • Avcc1a protein
  • GS-X protein
  • Mdrap protein
  • Mrp protein
  • Mrp1 protein

Protein level used designations for ABCC1

ATP-binding cassette transporter variant ABCC1delta-ex13 , ATP-binding cassette transporter variant ABCC1delta-ex13&14 , ATP-binding cassette transporter variant ABCC1delta-ex25 , ATP-binding cassette transporter variant ABCC1delta-ex25&26 , LTC4 transporter , leukotriene C(4) transporter , multidrug resistance-associated protein 1 , ATP-binding cassette, sub-family C (CFTR/MRP), member 1a , ATP-binding cassette, sub-family C (CFTR/MRP), member 1b , multiple drug resistance-associated protein , ATP-binding cassette sub-family C member 1 , multidrug resistance protein 1 , ATP-binding cassette sub-family C ( CFTR/MRP) member 1a , ATP-binding cassette, sub-family C (CFTR/MRP), member 1

GENE ID SPECIES
4363 Homo sapiens
17250 Mus musculus
403453 Canis lupus familiaris
281588 Bos taurus
395416 Gallus gallus
733619 Sus scrofa
100734674 Cavia porcellus
24565 Rattus norvegicus
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