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The protein encoded by ABCC10 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 10 Antibodies (82) and ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 10 Kits (4) and many more products for this protein.
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BAG3 (show BAG3 Proteins)-mediated miRNA let-7g and let-7i inhibit proliferation and enhance apoptosis of human esophageal carcinoma cells by targeting the drug transporter ABCC10 and modulates cisplatin resistance.
the combination of paclitaxel and masitinib could serve as a novel and useful therapeutic strategy to reverse paclitaxel resistance mediated by ABCC10
ABCC10 expression is correlated with human breast cancer subtype using breast tissue microarrays.
This report describes the ATPase activity of ABCC10 and further revealed ABCC10 localizes basolaterally using an in vitro system. The described work also identifies the tyrosine kinase (show TXK Proteins) sorafenib as an inhibitor of ABCC10.
Study establishes that ABCC10 is able to modulate taxane resistance in vivo using a mouse model.
Study establishes that ABCC10 confers resistance to several classes of agents including nucleoside analogs (cytabarine, dideoxycytidine) and epothilone B.
This study shows that ABCC10 confers resistance to the anticancer agents taxanes and vinca alkaloids in vitro.
MRP7 (show CFTR Proteins) has the facility for mediating the transport of conjugates such as E(2)17betaG indicates that it is a lipophilic anion transporter involved in phase III (cellular extrusion) of detoxification.
Tetrandrine and 5-bromotetrandrine can both reverse multidrug resistance in K562 cells by reducing expression of MRP7 (show CFTR Proteins).
Multivariate regression analysis identified carriage of a composite genotype of ABCC10 rs2125739 to be associated with nevirapine plasma concentrations
Importin 8 (show IPO8 Proteins) plays a critical role in mediating the cytoplasm-to-nucleus transport of mature miRNAs. IPO8 (show IPO8 Proteins)-mediated nuclear transport of mature miRNAs is also dependent on the association of IPO8 (show IPO8 Proteins) with the Argonaute 2 (show EIF2C2 Proteins) complex.
Abcc10 is dispensable for health and viability and it is an endogenous resistance factor for taxanes, other natural product agents, and nucleoside analogues
MDR1 (show ABCB4 Proteins) expression, MRP1 (show ABCC1 Proteins) expression, and MRP7 expression are refractory factors in head and neck cancer chemotherapy; induction of MRP7 expression is involved in drug resistance to natural products, especially to docetaxel in salivary gland adenocarcinoma
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.
ATP-binding cassette sub-family C member 10
, multidrug resistance-associated protein 7
, ATP-binding cassette, sub-family C (CFTR/MRP), member 10
, oocyte maturation 1
, ran-binding protein 8