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ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 Proteins (ABCC2)

The protein encoded by ABCC2 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 Antibodies (56) and ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ABCC2 1244 Q92887
ABCC2 12780 Q8VI47
Rat ABCC2 ABCC2 25303 Q63120
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Top ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 Proteins at antibodies-online.com

Showing 5 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

ABCC2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 (ABCC2) Interaction Partners

Human ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 (ABCC2) interaction partners

  1. A thalassemia patient has been found to be a carrier of UGT1A1 (show UGT1A1 Proteins) and ABCC2 polymorphisms explaining a possible reduction of desferasirox metabolism together with a reduction of biliary elimination by MRP2 and causing a serious adverse reaction.

  2. ABCC2 expression in PBMCs may be, in part, influenced by gender, and that at least two endogenous control genes should be utilized.

  3. Activation of liver PKCs during cholestasis leads to Ezrin (show EZR Proteins) Thr567 phosphorylation resulting in MRP2 internalization and degradation where ubiquitin ligase E3 GP78 (show AMFR Proteins) is involved.

  4. These studies identify Akt2 (show AKT2 Proteins) as a critical kinase that regulates radixin (show RDX Proteins) phosphorylation and leads to Mrp-2 translocation and function.

  5. MRP2 expression in HepG2 cells is repressed by IL-18 (show IL18 Proteins).

  6. MRP 2 expression is upregulated by ATP in colorectal cancer cells and enhances their survival to chemotherapeutic drugs.

  7. There was no association of ABCC2 with risk of colorectal cancer.

  8. CYP3A4 (show CYP3A4 Proteins)*22 and ABCC2 haplotypes did not influence tacrolimus trough concentrations

  9. ErbB2 (show ERBB2 Proteins) modulates gemcitabine and irinotecan/SN-38 chemoresistance of human pancreatic cancer cells via hCNT1 transporter and multidrug-resistance associated protein (show ABCC3 Proteins) MRP-2.

  10. Data show the influence of ABCC2 and ABCC4 polymorphisms on tenofovir plasma concentrations in Thai HIV-infected patients

Mouse (Murine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 (ABCC2) interaction partners

  1. Deficiency in Mrp2 lowers platinum excretion and increases susceptibility to kidney injury, which can be rescued by the human MRP2 ortholog.

  2. In Bcrp1;Mrp2;Mrp3(-/-), but not Bcrp1;Mdr1a/b;Mrp(-/-) mice.

  3. Cd or H(2)O(2) exposure increased the expression of key transport genes, Mrp1 (show ABCC1 Proteins) and Mrp2, in WT cells but not in metallothionein (show MT Proteins)-null cells.

  4. hepatic transporters Ntcp (show SLC10A1 Proteins) and Mrp2 are downregulated in rodent models of necrotizing enterocolitis

  5. Both Abcc2 and Abcc3 (show ABCC3 Proteins) significantly influenced the PK properties of MTX (show MTX1 Proteins).

  6. hyperosmotic cholestasis is triggered by a NADPH oxidase (show NOX1 Proteins)-driven reactive oxygen species formation that mediates Fyn (show FYN Proteins)-dependent retrieval of the Mrp2 and Bsep (show ABCB11 Proteins) from the canalicular membrane, which may involve an increased cortactin (show CTTN Proteins) phosphorylation.

  7. Strain- and sex-dependent circadian patterns in abcc2 expressions displayed robust relations with the chronotolerance of ileum mucosa for irinotecan

  8. In ABCC2-deficient mice impaired ABCC2 function is associated with a significant increase in erythromycin metabolism.

  9. Membrane vesicles prepared from human erythrocytes, which express the MRP2 have important implications for the Selenium-dependent and -independent disposition of Arasenic.

  10. NHERF-1 (show SLC9A3R1 Proteins) binds to Mrp2, and plays a critical role in the canalicular expression of Mrp2 and its function as a determinant of glutathione-dependent, bile acid-independent bile flow

ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 (ABCC2) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine\; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.

Gene names and symbols associated with ABCC2

  • ATP-binding cassette, sub-family C (CFTR/MRP), member 2 (ABCC2)
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 2 (Abcc2)
  • ATP-binding cassette, subfamily C (CFTR/MRP), member 2 (Abcc2)
  • Abc30 protein
  • AI173996 protein
  • Cmoat protein
  • cMRP protein
  • DJS protein
  • Mrp2 protein

Protein level used designations for ABCC2

ATP-binding cassette sub-family C member 2 , canalicular multidrug resistance protein , canalicular multispecific organic anion transporter 1 , multidrug resistance-associated protein 2 , multidrug resistance protein 2 , ATP-binding cassette, sub-family C (CFTR/MRP), member 2 , calicular multispecific organic anion transporter , multidrug resistance associated protein 2

GENE ID SPECIES
1244 Homo sapiens
12780 Mus musculus
25303 Rattus norvegicus
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