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ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 3 Proteins (ABCC3)

The protein encoded by ABCC3 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ABCC3 Antibodies (71) and ABCC3 Kits (14) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ABCC3 8714 O15438
ABCC3 76408 B2RX12
Rat ABCC3 ABCC3 140668 O88563
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Top ABCC3 Proteins at antibodies-online.com

Showing 4 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details

ABCC3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine) ,
,

More Proteins for ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 3 (ABCC3) Interaction Partners

Human ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 3 (ABCC3) interaction partners

  1. ABCC3 rs4148416 polymorphism was significantly associated with poor osteosarcoma response.

  2. Data suggest that hepatic expression of MRP3 is up-regulated and canalicular localization of MRP2 (show ABCC2 Proteins) is altered in pediatric patients with advanced nonalcoholic steatohepatitis; these alterations may be involved in changes observed in drug metabolism.

  3. ABCC3 expression may serve as a marker for MDR and predictor for poor clinical outcome of NSCLC.

  4. A functional Nrf2 (show GABPA Proteins) response element within the eighth intron of the ABCC3 gene.

  5. Renal function of MRP3 is related to renal cell proliferation and cyst formation and that restoring MRP3 may be an effective therapeutic approach for polycystic kidney disease.

  6. These results suggest that carboplatin and paclitaxel may induce drug resistance mediated by MDR1 and MRP3, which may be enhanced by the simultaneous use of both drugs.

  7. ABCC3 promoter methylation does not seem to exhibit any impact on maximum platelet aggregation and clopidogrel response at all

  8. Epidermal growth factor (show EGF Proteins) - mediated epithelial-mesenchymal transition induces ABCC3 mRNA in MDA-MB-468 breast cancer cells. The process is calcium dependant.

  9. Our data suggest that besides bodyweight, OCT1 (show POU2F1 Proteins) and ABCC3 genotypes play a significant role in the pharmacokinetics of intravenous morphine and its metabolites in children

  10. for ABCC3 variants, little evidence, if any, was found for an association of drug response to genetic variants

Mouse (Murine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 3 (ABCC3) interaction partners

  1. data show that this transporter activity is involved in ABCC3-induced senescence, demonstrating that this protein has a complex role in cancer, since its loss of function may promote escape from OIS and tumor formation

  2. Transport of cefadroxil by ABCC3 and ABCC4 was saturable with K(m) values of 2.5 +/- 0.7 and 0.25 +/- 0.07 mM, respectively.

  3. role of the bile acid membrane transporter Mrp3 (Abcc3), which is expressed in the liver and gut (show GUSB Proteins), in the hepatic growth response elicited by bile acids and in liver regeneration after partial hepatectomy

  4. Both Abcc2 (show ABCC2 Proteins) and Abcc3 significantly influenced the PK properties of MTX (show MTX1 Proteins).

  5. InsP(3)R2-mediated Ca(2 (show CA2 Proteins)+) signals enhance organic anion secretion into bile by targeting Mrp2 (show ABCC2 Proteins) to the canalicular membrane.

  6. Data show that Abcc2 (show ABCC2 Proteins), Abcc3, and Abcg2 together mediate the rapid elimination of MTX (show MTX1 Proteins) and 7OH-MTX (show MTX1 Proteins).

  7. These results suggest that Mrp3 plays major roles in the efflux transport of various glucuronide conjugates from the enterocytes to the portal blood in the small intestine together with unknown transporter(s)

  8. induction of Mrp3 plays a significant role in hepatocyte protection during obstructive cholestasis

  9. VDR (show CYP27B1 Proteins) has a role in the protection of colon cells from bile acid toxicity through regulation of the Mrp3 expression

  10. Mrp3 does not have a major role in bile salt physiology, but is involved in the transport of glucuronidated compounds, which could include glucuronidated bile salts in humans

ABCC3 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined\; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described\; however, not all variants have been fully characterized.

Gene names and symbols associated with ABCC3

  • ATP-binding cassette, sub-family C (CFTR/MRP), member 3 (ABCC3)
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 3 (Abcc3)
  • ATP-binding cassette, subfamily C (CFTR/MRP), member 3 (Abcc3)
  • 1700019L09Rik protein
  • ABC31 protein
  • cMOAT2 protein
  • EST90757 protein
  • Mlp2 protein
  • MOAT-D protein
  • Mrp3 protein

Protein level used designations for ABCC3

ATP-binding cassette sub-family C member 3 , canalicular multispecific organic anion transporter 2 , canicular multispecific organic anion transporter , multi-specific organic anion transporter D , multidrug resistance associated protein , multidrug resistance-associated protein 3 , ATP-binding cassette protein C3 , ATP-binding cassette transporter , transporter , ATP-binding cassette, sub-family C (CFTR/MRP), member 3 , MLP-2 , MRP-like protein 2 , multidrug resistance protein 3 , organic anion transporter

GENE ID SPECIES
8714 Homo sapiens
76408 Mus musculus
140668 Rattus norvegicus
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