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anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4) Antibodies

The protein encoded by ABCC4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ABCC4 Kits (3) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ABCC4 10257 O15439
ABCC4 239273  
ABCC4 170924  
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Top anti-ABCC4 Antibodies at antibodies-online.com

Showing 10 out of 124 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated IHC, ELISA, WB ABIN185302 staining (0.5µg/ml) of rat renal cortex membranes (20µg total protein per lane). Detected by western blot using chemiluminescence. Data kindly provided by Dr. Antje Steinbach, Ernst-Moritz-Arndt University of Greifswald. ABIN185302 (2.5µg/ml) staining of paraffin embedded Human Prostate. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Goat Un-conjugated EIA, IF, IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-ABCC4 Antibody (C-term) (ABIN391639) in CEM cell line lysates (35 µg/lane). ABCC4 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of anti-ABCC4 Antibody (C-term) in CEM cell line lysates (35ug/lane). ABCC4 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated FACS, IHC, ELISA, WB 0.1 mg Log in to see 3 to 4 Days
$430.10
Details
Human Mouse Un-conjugated WB ABCC4 monoclonal antibody (M03), clone 1B2 Western Blot analysis of ABCC4 expression in Hela NE on formalin-fixed paraffin-embedded human prostate (antibody concentration 3 µg/mL). 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Goat Un-conjugated EIA, WB AP23671PU-N ABCC4 antibody staining of Human Prostate lysate at 0.3 µg/ml (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Mouse Un-conjugated EIA, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$566.50
Details
Human Rabbit Un-conjugated WB Lane 3: Recombinant Human ABCC4 Protein 2.5ng 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-MRP4 Picoband antibody,  IHC(P): Rat Intestine Tissue Anti-MRP4 Picoband antibody,  IHC(P): Mouse Intestine Tissue 100 μg Log in to see 4 to 6 Days
$240.00
Details

ABCC4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-ABCC4 Antibodies

  1. Human Polyclonal ABCC4 Primary Antibody for IHC, ELISA - ABIN185302 : Schuetz, Connelly, Sun, Paibir, Flynn, Srinivas, Kumar, Fridland: MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs. in Nature medicine 1999 (PubMed)
    Show all 6 references for ABIN185302

  2. Human Monoclonal ABCC4 Primary Antibody for WB - ABIN394823 : Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010 (PubMed)
    Show all 5 references for ABIN394823

  3. Human Polyclonal ABCC4 Primary Antibody for EIA, WB - ABIN359599 : Lee, Belinsky, Bell, Testa, Kruh: Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter. in Cancer research 1998 (PubMed)
    Show all 4 references for ABIN359599

  4. Human Polyclonal ABCC4 Primary Antibody for WB - ABIN391639 : Adachi, Sampath, Lan, Sun, Hargrove, Flatley, Tatum, Edwards, Wezeman, Matherly, Drake, Schuetz: Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing. in The Journal of biological chemistry 2002 (PubMed)
    Show all 3 references for ABIN391639

  5. Human Polyclonal ABCC4 Primary Antibody for EIA, IF - ABIN374484 : Weerachayaphorn, Mennone, Soroka, Harry, Hagey, Kensler, Boyer: Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine. in American journal of physiology. Gastrointestinal and liver physiology 2012 (PubMed)
    Show all 3 references for ABIN374484

  6. Human Monoclonal ABCC4 Primary Antibody for FACS, IHC - ABIN1724860 : Bebes, Kis, Nagy, Kurunczi, Polyánka, Bata-Csörgo, Kemény, Dobozy, Széll: The expressions of ABCC4 and ABCG2 xenobiotic transporters in human keratinocytes are proliferation-related. in Archives of dermatological research 2012 (PubMed)

More Antibodies against ABCC4 Interaction Partners

Cow (Bovine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4) interaction partners

  1. MRP4 is a functional prostaglandin carrier under the regulation of oxytocin in the bovine endometrium.

Human ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4) interaction partners

  1. Results demonstrated the capacity of MRP4 to confer resistance to arsenite (AsIII), as evidenced by cell survival assays when treated with AsIII in the presence or absence of its two differential inhibitors.

  2. Osteoarthritis patient platelets presented a higher expression of MRP4.

  3. Sulfate metabolites R-6-S and R-4'-S were generated from raloxifene in SULT293 expression HEK293 cells. Cellular excretion of the raloxifene sulfates was mainly mediated by BCRP and MRP4.

  4. the specific COX-2 inhibitor meloxicam can increase the intracellular accumulation of doxorubicin and enhance doxorubicin-induced cytotoxicity in A549 cancer cells by reducing the expression of MRP1 and MRP4.

  5. MRP4 overexpression is important to reduce aspirin-selective cell death

  6. Approximately 20% of HIV-infected patients receiving tenofovir showed beta2-microglobulinuria. The C allele at position 4976 of the ABCC4 gene was associated with beta2-microglobulinuria in this population.

  7. MRP4 genotyping may be useful for personalizing the therapeutic dose of 6-mercaptopurine during the acute lymphoblastic leukemia maintenance therapy in Japanese

  8. Genetic variability in ABCC4 may contribute to misoprostol-induced fever in pregnant women

  9. ABCC4 levels were significantly upregulated both in human NK/T-cell lymphoma YTS (show Yars Antibodies) and SNK-6 cells. ABCC4 overexpression induced chemotherapy resistance to epirubicin and cisplatin in YTS (show Yars Antibodies) cells, and inhibited apoptosis.

  10. These findings have important clinical implications because they directly highlight an important relationship between ABCC4 transporter function and phosphodiesterases in accounting for the cAMP-directed activity of antithrombotic agents.

Mouse (Murine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4) interaction partners

  1. These findings have important clinical implications because they directly highlight an important relationship between ABCC4 transporter function and phosphodiesterases in accounting for the cAMP-directed activity of antithrombotic agents.

  2. A novel cAMP-dependent mechanism for MRP4-mediated regulation of fibroblast migration and indicated that PKA and actin play important roles as downstream effectors.

  3. Loss of MRP4 is associated with impaired platelet activation and cAMP homeostasis

  4. Upregulation of COX-2 in lung cancer promotes overexpression of MRP4 via PGE2-dependent pathway

  5. role of MRP4 in thrombus formation

  6. NHERF3 is a key regulator of organic transport in the kidney, particularly MRP4-mediated clearance of drug molecules.

  7. Abcc4 in the stomach facilitates the oral absorption of dasatinib, and it possibly plays a similar role for other orally administered substrates, such as acetylsalicylic acid.

  8. Mrp4 is not essential for the recruitment of neutrophils into the lung after LPS (show TLR4 Antibodies) or CS exposure or of eosinophils after allergen exposure

  9. Data indicate that Abcc4 limits the brain penetration of camptothecin analogues and teams up with Abcb1a (show ABCB4 Antibodies)/b and Abcg2 (show ABCG2 Antibodies) to form a robust cooperative drug efflux system.

  10. Multi-drug resistance protein 4 (MRP4)-mediated regulation of fibroblast cell migration reflects a dichotomous role of intracellular cyclic nucleotides.

ABCC4 Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined\; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms.

Gene names and symbols associated with ABCC4

  • ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (ABCC4) antibody
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (abcc4) antibody
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (Abcc4) antibody
  • ATP-binding cassette, subfamily C (CFTR/MRP), member 4 (Abcc4) antibody
  • D630049P08Rik antibody
  • EST170205 antibody
  • MOAT-B antibody
  • MOATB antibody
  • Mrp4 antibody

Protein level used designations for ABCC4

multidrug resistance-associated protein 4 , ATP-binding cassette, sub-family C (CFTR/MRP), member 4 , ATP-binding cassette protein C4-like , multidrug resistance-associated protein 4-like , ATP-binding cassette sub-family C member 4 , MRP/cMOAT-related ABC transporter , bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4) , canalicular multispecific organic anion transporter (ABC superfamily) , multi-specific organic anion transporter B , multispecific organic anion transporter B , ABC-tranporter , ATP-binding cassette protein C4

GENE ID SPECIES
485523 Canis lupus familiaris
515333 Bos taurus
616707 Bos taurus
695407 Macaca mulatta
100027089 Monodelphis domestica
100050431 Equus caballus
100081616 Ornithorhynchus anatinus
100391624 Callithrix jacchus
100466405 Ailuropoda melanoleuca
100491006 Xenopus (Silurana) tropicalis
10257 Homo sapiens
239273 Mus musculus
170924 Rattus norvegicus
Selected quality suppliers for anti-ABCC4 (ABCC4) Antibodies
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