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The protein encoded by ABCC4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ABCC4 Kits (3) and and many more products for this protein.
Showing 10 out of 124 products:
Human Polyclonal ABCC4 Primary Antibody for IHC, ELISA - ABIN185302
Schuetz, Connelly, Sun, Paibir, Flynn, Srinivas, Kumar, Fridland: MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs. in Nature medicine 1999
Show all 6 references for ABIN185302
Human Monoclonal ABCC4 Primary Antibody for WB - ABIN394823
Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010
Show all 5 references for ABIN394823
Human Polyclonal ABCC4 Primary Antibody for EIA, WB - ABIN359599
Lee, Belinsky, Bell, Testa, Kruh: Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter. in Cancer research 1998
Show all 4 references for ABIN359599
Human Polyclonal ABCC4 Primary Antibody for WB - ABIN391639
Adachi, Sampath, Lan, Sun, Hargrove, Flatley, Tatum, Edwards, Wezeman, Matherly, Drake, Schuetz: Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing. in The Journal of biological chemistry 2002
Show all 3 references for ABIN391639
Human Polyclonal ABCC4 Primary Antibody for EIA, IF - ABIN374484
Weerachayaphorn, Mennone, Soroka, Harry, Hagey, Kensler, Boyer: Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine. in American journal of physiology. Gastrointestinal and liver physiology 2012
Show all 3 references for ABIN374484
Human Monoclonal ABCC4 Primary Antibody for FACS, IHC - ABIN1724860
Bebes, Kis, Nagy, Kurunczi, Polyánka, Bata-Csörgo, Kemény, Dobozy, Széll: The expressions of ABCC4 and ABCG2 xenobiotic transporters in human keratinocytes are proliferation-related. in Archives of dermatological research 2012
MRP4 is a functional prostaglandin carrier under the regulation of oxytocin in the bovine endometrium.
Results demonstrated the capacity of MRP4 to confer resistance to arsenite (AsIII), as evidenced by cell survival assays when treated with AsIII in the presence or absence of its two differential inhibitors.
Osteoarthritis patient platelets presented a higher expression of MRP4.
Sulfate metabolites R-6-S and R-4'-S were generated from raloxifene in SULT293 expression HEK293 cells. Cellular excretion of the raloxifene sulfates was mainly mediated by BCRP and MRP4.
the specific COX-2 inhibitor meloxicam can increase the intracellular accumulation of doxorubicin and enhance doxorubicin-induced cytotoxicity in A549 cancer cells by reducing the expression of MRP1 and MRP4.
MRP4 overexpression is important to reduce aspirin-selective cell death
Approximately 20% of HIV-infected patients receiving tenofovir showed beta2-microglobulinuria. The C allele at position 4976 of the ABCC4 gene was associated with beta2-microglobulinuria in this population.
MRP4 genotyping may be useful for personalizing the therapeutic dose of 6-mercaptopurine during the acute lymphoblastic leukemia maintenance therapy in Japanese
Genetic variability in ABCC4 may contribute to misoprostol-induced fever in pregnant women
ABCC4 levels were significantly upregulated both in human NK/T-cell lymphoma YTS (show Yars Antibodies) and SNK-6 cells. ABCC4 overexpression induced chemotherapy resistance to epirubicin and cisplatin in YTS (show Yars Antibodies) cells, and inhibited apoptosis.
These findings have important clinical implications because they directly highlight an important relationship between ABCC4 transporter function and phosphodiesterases in accounting for the cAMP-directed activity of antithrombotic agents.
A novel cAMP-dependent mechanism for MRP4-mediated regulation of fibroblast migration and indicated that PKA and actin play important roles as downstream effectors.
Loss of MRP4 is associated with impaired platelet activation and cAMP homeostasis
Upregulation of COX-2 in lung cancer promotes overexpression of MRP4 via PGE2-dependent pathway
role of MRP4 in thrombus formation
NHERF3 is a key regulator of organic transport in the kidney, particularly MRP4-mediated clearance of drug molecules.
Abcc4 in the stomach facilitates the oral absorption of dasatinib, and it possibly plays a similar role for other orally administered substrates, such as acetylsalicylic acid.
Mrp4 is not essential for the recruitment of neutrophils into the lung after LPS (show TLR4 Antibodies) or CS exposure or of eosinophils after allergen exposure
Data indicate that Abcc4 limits the brain penetration of camptothecin analogues and teams up with Abcb1a (show ABCB4 Antibodies)/b and Abcg2 (show ABCG2 Antibodies) to form a robust cooperative drug efflux system.
Multi-drug resistance protein 4 (MRP4)-mediated regulation of fibroblast cell migration reflects a dichotomous role of intracellular cyclic nucleotides.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined\; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms.
multidrug resistance-associated protein 4
, ATP-binding cassette, sub-family C (CFTR/MRP), member 4
, ATP-binding cassette protein C4-like
, multidrug resistance-associated protein 4-like
, ATP-binding cassette sub-family C member 4
, MRP/cMOAT-related ABC transporter
, bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4)
, canalicular multispecific organic anion transporter (ABC superfamily)
, multi-specific organic anion transporter B
, multispecific organic anion transporter B
, ATP-binding cassette protein C4