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ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 5 Proteins (ABCC5)

The protein encoded by ABCC5 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ABCC5 Antibodies (85) and ABCC5 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ABCC5 10057 O15440
ABCC5 27416 Q9R1X5
Rat ABCC5 ABCC5 116721 Q9QYM0
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Top ABCC5 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

ABCC5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 5 (ABCC5) Interaction Partners

Human ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 5 (ABCC5) interaction partners

  1. genetic association study in population in Mexico: Data suggest SNPs in ABCC5 (3933+313T>C) are not associated with adverse reactions to methotrexate; they protect against myelosuppression in pediatric patients with ALL (acute lymphoblastic leukemia).

  2. We identified several genes (FasL (show FASL Proteins), MSH2 (show MSH2 Proteins), ABCC5, CASP3 (show CASP3 Proteins), and CYP3A4 (show CYP3A4 Proteins))that showed association with PFS in patients with osteosarcoma. These pharmacogenetic risk factors might be useful to predict treatment outcome

  3. ABCC5 is a general glutamate (show GRIN1 Proteins) conjugate and analog transporter that affects the disposition of endogenous metabolites, toxins, and drugs.

  4. The present study investigated the time course and dose dependency of the induction of three efflux proteins, P-gp (show ABCB4 Proteins), MRP1 (show MDM4 Proteins) and MRP5, in response to gemcitabine exposure in Capan-2 pancreatic cancer cell line at transcriptional and translational levels.

  5. cCMP is a substrate for MRP5

  6. The blockade of ABC transporter MRP5 could help to improve drug effectiveness, reduce tumour growth and prevent recurrence in glioblastoma multiforme.

  7. To identify substrates of orphan transporter ATP-binding cassette subfamily C member 5 (ABCC5), identified a class of metabolites, N-lactoyl-amino acids, and found that a protease, cytosolic nonspecific dipeptidase 2 (CNDP2 (show CNDP2 Proteins)), catalyzes their formation.

  8. ABCC5 transporter is a novel type 2 diabetes susceptibility gene in European and African American populations.

  9. ABCC5 functions as a mediator of breast cancer skeletal metastasis. ABCC5 expression in breast cancer cells is important for efficient osteoclast-mediated bone resorption.

  10. Further research is needed to clarify whether MRP5 is indicative of malignant pathological features in meningiomas and whether possible therapeutic implications exist

Mouse (Murine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 5 (ABCC5) interaction partners

  1. ABCC5 is a general glutamate (show GRIN1 Proteins) conjugate and analog transporter that affects the disposition of endogenous metabolites, toxins, and drugs.

  2. Deficiency of MKP5 (show DUSP10 Proteins) resulted in increased inflammatory activation in macrophages. These findings thus demonstrate that MKP5 (show DUSP10 Proteins) critically controls inflammation in white adipose tissue and the development of metabolic disorders

  3. Reduced cGMP export as a consequence of decreased MRP5 expression can attenuate heart failure in sepsis.

ABCC5 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected\; however, the complete sequence and translation initiation site is unclear.

Gene names and symbols associated with ABCC5

  • ATP-binding cassette, sub-family C (CFTR/MRP), member 5 (ABCC5)
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 5 (Abcc5)
  • ATP-binding cassette, subfamily C (CFTR/MRP), member 5 (Abcc5)
  • immunoglobulin heavy variable 9-4 (Ighv9-4)
  • 2900011L11Rik protein
  • ABC33 protein
  • Abcc5a protein
  • Abcc5b protein
  • AI132311 protein
  • EG636260 protein
  • EST277145 protein
  • Gm7175 protein
  • MOAT-C protein
  • MOATC protein
  • Mrp5 protein
  • pABC11 protein
  • SMRP protein

Protein level used designations for ABCC5

ATP-binding cassette sub-family C member 5 , canalicular multispecific organic anion transporter C , multi-specific organic anion transporter C , multidrug resistance-associated protein 5 , ATP-binding cassette, sub-family C (CFTR/MRP), member 5a , ATP-binding cassette, sub-family C (CFTR/MRP), member 5b , ATP-binding cassette, sub-family C, member 5 , MOAT-C , SMRP , ATP-binding cassette sub-family C (CFTR/MRP) member 5a , ATP-binding cassette, sub-family C (CFTR/MRP), member 5

GENE ID SPECIES
10057 Homo sapiens
27416 Mus musculus
116721 Rattus norvegicus
636260 Mus musculus
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