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ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 6 Proteins (ABCC6)

The protein encoded by ABCC6 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ABCC6 Antibodies (26) and ABCC6 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ABCC6 368 O95255
ABCC6 27421 Q9R1S7
Rat ABCC6 ABCC6 81642 O88269
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Top ABCC6 Proteins at antibodies-online.com

Showing 5 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

ABCC6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 6 (ABCC6) Interaction Partners

Human ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 6 (ABCC6) interaction partners

  1. Pseudoxanthoma elasticum is due to mutation of the ABCC6 gene on chromosome 16.

  2. Membrane insertion and topology of the amino-terminal domain TMD0 of multidrug-resistance associated protein 6

  3. A direct relationship between reduced ABCC6 levels and the expression of pro-mineralization genes in hepatocytes.

  4. Minimal rescue of the morpholino-induced phenotype was achieved with eight of the nine mutant human ABCC6 mRNAs tested, implying pathogenicity. This study demonstrates that the Chinese PXE population harbors unique ABCC6 mutations.

  5. Virtual screening expands this possibility to explore more compounds that can interact with ABCC6, and may aid in understanding the mechanisms leading to pseudoxanthoma elasticum

  6. The increase in ABCC6 expression accompanied by the induction of cholesterol biosynthesis supposes a functional role for ABCC6 in human lipoprotein and cholesterol homeostasis.

  7. ABCC6 gene is important to determine the genotype of patients diagnosed with pseudoxanthoma elasticum.

  8. Hepatic ABCC6-mediated ATP release is the main source of circulating PPi, revealing an unanticipated role of the liver in systemic PPi homeostasis.

  9. This study describes the URG7 expression in E.coli and a structural study of it by using circular dichroism and fluorescence spectroscopy.

  10. This study showed that the expression of ABCC6 in liver is an important determinant of calcification in cardiac tissues in response to injuries

Mouse (Murine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 6 (ABCC6) interaction partners

  1. bisphosphonates may be helpful for prevention of mineral deposits in Pseudoxanthoma elasticum and generalized arterial calcification of infancy caused by mutations in the ABCC6 gene.

  2. In a mouse model of CKD, ABCC6 protein expression was decreased in liver and kidney, however mRNA levels were unchanged.

  3. In the Abcc6(-/-) genotype, dermal fibroblasts actively contribute to changes that promote matrix calcification; these cells can be further modulated with time by the calcified environment, contributing to the age-dependent progression.

  4. This study showed that the expression of ABCC6 in liver is an important determinant of calcification in cardiac tissues in response to injuries

  5. Magnesium oxide reduces carotid intima media thickness in Abcc6-/- mouse model for pseudoxanthoma elasticum.

  6. Studied the role of genetic modulation and the role of diet in nephrocalcinosis using two established mouse models of ectopic mineralization, Abcc6(tm1Jfk) and Enpp1 (show ENPP1 Proteins)(asj (show ARSJ Proteins)) mice.

  7. Report lower elasticity and increased myogenic tone without major changes in agonist-dependent contraction in aged Abcc6(-/-) mouse model of pseudoxanthoma elasticum.

  8. the development of cardiac hypertrophy in the 24-month-old Abcc6(-/-) mice suggests that old pseudoxanthoma elasticum patients might be prone to developing late cardiopathy.

  9. ABCC6 is in the basolateral membrane, mediating the sinusoidal efflux of a metabolite from the hepatocytes to systemic circulation.

  10. A single-nucleotide polymorphism in the Abcc6 gene associates with connective tissue mineralization in mice similar to targeted models for pseudoxanthoma elasticum.

ABCC6 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene.

Gene names and symbols associated with ABCC6

  • ATP-binding cassette, sub-family C (CFTR/MRP), member 6 (ABCC6)
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 6 (Abcc6)
  • ATP-binding cassette, subfamily C (CFTR/MRP), member 6 (Abcc6)
  • ABC34 protein
  • Abcc1b protein
  • ARA protein
  • DCC protein
  • dyscalc protein
  • Dyscalc1 protein
  • EST349056 protein
  • GACI2 protein
  • MLP1 protein
  • MOAT-E protein
  • MOATE protein
  • Mrp6 protein
  • PXE protein
  • PXE1 protein
  • URG7 protein

Protein level used designations for ABCC6

ATP-binding cassette sub-family C member 6 , anthracycline resistance-associated protein , multi-specific organic anion transporter E , multidrug resistance-associated protein 6 , ATP-binding cassette, sub-family C, member 6 , multidrug resistance-associated protein-6 , ATP-binding cassette, sub-family C (CFTR/MRP), member 6 , MLP-1 , MRP-like protein 1 , liver multidrug resistance-associated protein 6

GENE ID SPECIES
368 Homo sapiens
27421 Mus musculus
81642 Rattus norvegicus
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