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ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) ELISA Kits

The protein encoded by ABCC8 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ABCC8 Antibodies (83) and ABCC8 Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
ABCC8 6833 Q09428
Anti-Mouse ABCC8 ABCC8 20927  
Anti-Rat ABCC8 ABCC8 25559 Q09429
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Top ABCC8 ELISA Kits at

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Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Human 0.128ng/mL 0.313-20 ng/mL 96 Tests Log in to see 11 to 12 Days

More ELISA Kits for ABCC8 Interaction Partners

Human ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) interaction partners

  1. ABCC8 mutation is associated with persistently elevated insulin (show INS ELISA Kits) concentrations.

  2. A study of mutations in the ABCC8 gene that cause congenital hyperinsulinism demonstrate a clear functional distinction between SUR1 nucleotide-binding domain two (NBD2) and transmembrane domain (TMD (show TTN ELISA Kits)) mutants

  3. up-regulation of SUR1 in humans point to this channel as one of the important molecular players in the pathophysiology of Post-traumatic brain contusions

  4. HNF1A (show HNF1A ELISA Kits) gene mutations represented the second most frequent genetic cause of congenital hyperinsulinism of infancy in the Czech Republic

  5. single amino acid difference can account for the markedly different diazoxide sensitivities between channels containing either the SUR1 or SUR2A (show ABCC9 ELISA Kits) subunit isoforms.

  6. Mutations in ABCC8 are associated with neonatal diabetes mellitus.

  7. First description of a homozygous p.R1419H mutation in ABCC8 in a family leading to postprandial hyperglycemia followed by hypoglycemia.

  8. in a cohort of hyperinsulinemic hypoglycemia patients from Isfahan, Iran, 78% were noted to have disease-causing mutations: 48% had HADH (show HADHA ELISA Kits) mutations and 26% had ABCC8 mutations.

  9. genome-wide association studies in population of Pima Indians in Arizona: Data suggest that R1420H loss-of-function variant in ABCC8 is associated with higher birth weights and twofold increased risk for type 2 diabetes with 7-year earlier onset age.

  10. These calculations identified causal genetic variation within the ABCC8/KCNJ11 (show KCNJ11 ELISA Kits) region for type 2 diabetes mellitus.

Mouse (Murine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) interaction partners

  1. study provides evidence for a role of Abcc8(ATP-binding cassette sub-family C) in early-phase glucose-mediated insulin (show INS ELISA Kits) secretion and validates this gene as a contributor to beta-cell dysfunction in type 2 diabetes

  2. We conclude that the gradual development of glucose intolerance in patients with the SUR1-E1506K mutation might, as in the mouse model, result from impaired insulin (show INS ELISA Kits) secretion due a failure of insulin (show INS ELISA Kits) content to increase with age.

  3. The results confirm that Kir6.2 (show KCNJ11 ELISA Kits) contributes to APD shortening in both atria and ventricle during metabolic stress, and that SUR1 is required for atrial APD shortening while SUR2A (show ABCC9 ELISA Kits) is required for ventricular APD shortening.

  4. EPAC (show RAPGEF3 ELISA Kits) interaction with SUR1 controls seizure susceptibility and possibly acts via regulation of glutamate (show GRIN1 ELISA Kits) release.

  5. the role of CpG methylation in regulating SUR1 and SUR2 (show ABCC9 ELISA Kits) expression

  6. SUR1 controls K(ATP) channel activity but not TRPM4 (show TRPM4 ELISA Kits) channels.

  7. Conserved intramolecular disulfide bond is critical to trafficking and fate of ATP-binding cassette (ABC (show ABCB6 ELISA Kits)) transporters ABCB6 (show ABCB6 ELISA Kits) and sulfonylurea receptor 1 (SUR1)/ABCC8.

  8. ATP regulates pancreatic beta-cell K(ATP) channel activity, not only by its direct actions on Kir6.2 pore subunit, but also via ATP modulation of Syn-1A binding to SUR1.

  9. Diazoxide does not open the ventricular sarcolemmal adenosine triphosphate-sensitive potassium channel but provides volume homeostasis via an SUR1-dependent pathway in mouse ventricular myocytes.

  10. The role of Abcc8, which encodes sulfonylurea receptor 1 (SUR1), was assessed in progressive hemorrhagic necrosis.

Pig (Porcine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) interaction partners

  1. islets express mRNA transcripts for sulfonylurea receptor 1 (Sur1), inward rectifying potassium channel (show KCNAB2 ELISA Kits) (Kir6.2 (show KCNJ11 ELISA Kits), associated with Sur1), glucagon-like peptide 1 receptor (GLP1R (show GLP1R ELISA Kits)), and adrenergic receptor alpha 2A (show ADRA2A ELISA Kits) (ADRalpha2A)

ABCC8 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed\; however, the transcript variants have not been fully described.

Gene names and symbols associated with ABCC8

  • ATP-binding cassette, sub-family C (CFTR/MRP), member 8 (ABCC8) antibody
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 8 (Abcc8) antibody
  • ATP-binding cassette, subfamily C (CFTR/MRP), member 8 (Abcc8) antibody
  • ABC36 antibody
  • D930031B21Rik antibody
  • HHF1 antibody
  • HI antibody
  • HRINS antibody
  • MRP8 antibody
  • PHHI antibody
  • Sur antibody
  • Sur1 antibody
  • SUR1delta2 antibody
  • TNDM2 antibody

Protein level used designations for ABCC8

ATP-binding cassette, sub-family C (CFTR/MRP), member 8 , ATP-binding cassette, sub-family C, member 8 , ATP-binding cassette sub-family C member 8 , ATP-binding cassette transporter sub-family C member 8 , sulfonylurea receptor (hyperinsulinemia) , sulfonylurea receptor 1 , sulfonylurea receptor , sulphonylurea receptor 1

423072 Gallus gallus
451056 Pan troglodytes
654490 Macaca mulatta
6833 Homo sapiens
20927 Mus musculus
485402 Canis lupus familiaris
538996 Bos taurus
100158245 Sus scrofa
100722700 Cavia porcellus
25559 Rattus norvegicus
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