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ATP-Binding Cassette, Sub-Family D (ALD), Member 2 (Abcd2) ELISA Kits

The protein encoded by Abcd2 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping Abcd2 Antibodies (24) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human Abcd2 Abcd2 225 Q9UBJ2
Anti-Mouse Abcd2 Abcd2 26874 Q61285
Anti-Rat Abcd2 Abcd2 84356 Q9QY44
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More ELISA Kits for Abcd2 Interaction Partners

Human ATP-Binding Cassette, Sub-Family D (ALD), Member 2 (Abcd2) interaction partners

  1. ABCD1 (show ABCD1 ELISA Kits) and ABCD2 are involved in the transport of long and very long chain fatty acids (VLCFA) or their CoA-derivatives into peroxisomes with different substrate specificities, while ABCD3 (show ABCD3 ELISA Kits) is involved in the transport of branched chain acyl-CoA (show GNPAT ELISA Kits) into peroxisomes.ABCD4 is deduced to take part in the transport of vitamin B12 (show NDUFB3 ELISA Kits) from lysosomes into the cytosol.

  2. 13-cis (show CISH ELISA Kits)-retinoic acid induces ABCD2 expression in human monocytes/macrophages.

  3. ABCD2 has a role, but not a strong one, in risk of early recurrent events after transient ischemic attack

  4. results show that although patients with ABCD2 score greater than 4 were more likely to develop recurrent TIA/CVA in short term, those with lesser score still harbour a considerable risk for TIA/CVA

  5. The transcriptional activity of the ABCD2 promoter was strongly increased by ectopic expression of beta-catenin (show CTNNB1 ELISA Kits) and TCF-4 (show TCF4 ELISA Kits).

  6. LXRalpha (show NR1H3 ELISA Kits) is a negative modulator of Abcd2, acting through a novel regulatory mechanism involving overlapping SREBP and LXRalpha (show NR1H3 ELISA Kits) binding sites

  7. Testosterone metabolites increased expression of ABCD2 mRNA in fibroblasts from X-linked adrenoleukodystrophy patients.

  8. These findings are of particular importance for the attempt of pharmacological induction of ABCD2 as a possible therapeutic approach in X-linked adrenoleukodystrophy.

  9. LDRP (ABCD2) interacts with both farnesylated wild-type and farnesylation-deficient mutant PEX19 (show PEX19 ELISA Kits). This interaction is mediated by amino acids 1-218 of ALDRP.

  10. ALDRP interacts with PMP70 (show ABCD3 ELISA Kits). This interaction occurs via the ALDRP C-terminus [374-740] and the PMP70 (show ABCD3 ELISA Kits) C-terminus [338-659]. This interaction was demonstrated using human PMP70 (show ABCD3 ELISA Kits) and mouse ALDRP.

Mouse (Murine) ATP-Binding Cassette, Sub-Family D (ALD), Member 2 (Abcd2) interaction partners

  1. Abcd2 is a strong modifier of the metabolic impairments in peritoneal macrophages of ABCD1 (show ABCD1 ELISA Kits)-deficient mice

  2. The absence of ABCD2 altered expression of gene clusters associated with lipid metabolism, including PPARalpha (show PPARA ELISA Kits) signaling.

  3. ABCD2 is a sterol regulatory element binding protein (show CNBP ELISA Kits) target gene that is highly abundant in fat and opposes the accumulation of dietary lipids generally absent from the triglyceride storage pool within adipose tissue.

  4. Evidence against the adrenoleukodystrophy-related gene acting as a modifier of X-adrenoleukodystrophy.

  5. LXRalpha (show NR1H3 ELISA Kits) is a negative modulator of Abcd2, acting through a novel regulatory mechanism involving overlapping SREBP and LXRalpha (show NR1H3 ELISA Kits) binding sites

  6. Abcd1 (show ABCD1 ELISA Kits) and Abcd2 gene silencing sensitizes astrocytes for inflammation and may have a role in X-adrenoleukodystrophy

  7. ABCD2 plays a role in th degradation of long-chain saturated and omega9-monounsaturated fatty acids and in the synthesis of docosahexanoic acid.

Abcd2 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown\; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis.

Gene names and symbols associated with Abcd2

  • ATP-binding cassette, sub-family D (ALD), member 2 (ABCD2) antibody
  • ABC transporter D family protein (abcD2) antibody
  • ATP-binding cassette, sub-family D (ALD), member 2 (abcd2) antibody
  • ATP-binding cassette, sub-family D (ALD), member 2 (Abcd2) antibody
  • ATP-binding cassette, subfamily D (ALD), member 2 (Abcd2) antibody
  • ABC39 antibody
  • ALDL1 antibody
  • ALDR antibody
  • ALDRP antibody
  • DDBDRAFT_0214891 antibody
  • DDBDRAFT_0219834 antibody
  • DDB_0214891 antibody
  • DDB_0219834 antibody
  • hALDR antibody

Protein level used designations for Abcd2

ATP-binding cassette, sub-family D, member 2 , ATP-binding cassette, sub-family D (ALD), member 2 , ATP-binding cassette sub-family D member 2 , ATP-binding cassette sub-family D member 2-like , adrenoleukodystrophy-like 1 , adrenoleukodystrophy-related protein , adrenoleukodystrophy related

GENE ID SPECIES
466952 Pan troglodytes
477643 Canis lupus familiaris
526436 Bos taurus
8629134 Dictyostelium discoideum AX4
100413459 Callithrix jacchus
100520309 Sus scrofa
417694 Gallus gallus
697556 Macaca mulatta
100019263 Monodelphis domestica
100433322 Pongo abelii
100549247 Meleagris gallopavo
100556516 Anolis carolinensis
100583742 Nomascus leucogenys
100640478 Amphimedon queenslandica
225 Homo sapiens
26874 Mus musculus
84356 Rattus norvegicus
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