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The protein encoded by ABCA7 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ABCA7 Kits (11) and ABCA7 Proteins (4) and many more products for this protein.
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ABCA7 does not play a significant role in the regulation of cell proliferation or neurogenesis in the adult mouse.
This study demonstrated that novel mechanism underlying how dysfunctions of ABCA7 contribute to the risk for alzheimer disease.
ABCA7 has a role in Alzheimer amyloid processing
Theresults of this study suggested that ABCA7 plays a role in the regulation of Abeta (show APP Antibodies) homeostasis in the brain and that this may be related to altered phagocyte function.
ABCA7 may play a role in T cell proliferation and erythropoeisis in spleen
concluded that statins enhance macrophage phagocytosis through the SREBP-ABCA7 pathway.
Data suggest that extracellular helical apolipoproteins augment ABCA7-associated phagocytosis by stabilizing ABCA7, and show direct enhancement of the host defense system by HDL (show HSD11B1 Antibodies) components.
ABCA7 has the ability to bind apolipoproteins and promote efflux of cellular phospholipids without cholesterol, and has a possible role of ABCA7 in cellular phospholipid metabolism in peripheral tissues
genetic knockdown of ABCA7 in mouse peritoneal macrophages did not affect phospholipid or cholesterol efflux to apoA-I (show APOA1 Antibodies)
ABCA7 plays a novel role in lipid and fat metabolism
Results confirm that ABCA7 loss of function variants are enriched in patients with Alzheimer disease and extend this finding to predicted damaging missense variants
A detailed clinicopathologic description of patients carrying an ABCA7 loss of function mutation: a classical Alzheimer disease phenotype, though with a striking wide onset age range, suggesting the influence of unknown modifying factors
Results suggested that ABCA7 genotypes contribute to the AD risk through involvement in amyloid-beta deposition on in vivo imaging, but not in tau pathology, brain atrophy, or decreased glucose metabolism
Common variants in ABCA7 and MS4A6A (show MS4A6A Antibodies) are associated with cortical and hippocampal atrophy.
Studies indicate that ATP-binding cassette transporter (show ABCA4 Antibodies) A7 (ABCA7) single nucleotide polymorphisms (SNPs) that increase Alzheimer's disease (AD) risk.
Study replicates the association of ABCA7 loss-of-function variants with Alzheimer's disease risk, and highlights the necessity of performing gene-based, rather than single-variant analyses to replicate the association in this type of studies
The results are consistent with the view that assembly of HDL particles with extracellular apoA-I is primarily with the cellular phospholipid molecules being regulated in part by their physicochemical nature.
Loss-of-function of ABCA7 could be a potential mechanism of Alzheimer's disease as shown in a Belgian cohort.
Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease in Icelanders. [meta-analysis]
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known\; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system.
ATP-binding cassette sub-family A member 7
, ATP-binding cassette, sub-family A, member 7
, ATP-binding cassette, sub-family A (ABC1), member 7
, autoantigen SS-N
, macrophage ABC transporter