anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11 (ABCB11) Antibodies

The membrane-associated protein encoded by ABCB11 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ABCB11 Kits (12) and ABCB11 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ABCB11 8647 O95342
ABCB11 27413 Q9QY30
ABCB11 83569 O70127
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Top anti-ABCB11 Antibodies at antibodies-online.com

Showing 10 out of 59 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB Anti- ABCB11 Picoband antibody, IHC(P) IHC(P): Human Liver Cancer Tissue Anti- ABCB11 Picoband antibody, Western blotting All lanes: Anti ABCB11  at 0.5ug/ml Lane 1: Rat Liver Tissue Lysate at 50ug Lane 2: Mouse Liver Tissue Lysate at 50ug Lane 3: SMMC Whole Cell Lysate at 40ug Predicted bind size: 146KD Observed bind size: 146KD 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-ABCB11 C-term Pab (ABIN390059) is used in Western blot to detect ABCB11 in mouse liver tissue lysate. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC, IHC (p) Western Blot: ABCB11 Antibody [NBP1-89319] - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10 Lane 2: Human Tonsil tissue Immunohistochemistry: ABCB11 Antibody [NBP1-89319] - Staining of human liver shows moderate membranous positivity in hepatocytes. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Mouse Un-conjugated ICC, IHC (p), WB Human Liver (formalin-fixed, paraffin-embedded) stained with ABCB11 antibody ABIN305775 at 5 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 7 to 9 Days
$676.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat pancreatic tissue labeled with Anti-BSEP/ABCB11 Polyclonal Antibody, Unconjugated (ABIN675848) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded rat pancreatic tissue labeled with Anti-BSEP/ABCB11 Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$295.90
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB ICC/IF Image BSEP antibody [N3C1], Internal detects ABCB11 protein at membrane by immunofluorescent analysis. Sample: A431 cells were fixed in ice-cold MeOH for 5 min. Green: ABCB11 protein stained by BSEP antibody [N3C1], Internal , diluted at 1:500. Blue: Hoechst 33343 staining. WB Image Sample (30 ug of whole cell lysate) A: JurKat 5% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 1 to 2 Days
$358.60
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), IHC, WB Immunocytochemistry/Immunofluorescence: ABCB11 Antibody [NBP1-31824] - Sample: A431 cells were fixed in iced-cold MeOH for 5 min. Green: ABCB11 protein stained by BSEP antibody, Internal diluted at 1:500. Blue: Hoechst 33343 staining. Western Blot: ABCB11 Antibody [NBP1-31824] - Sample (30 ug of whole cell lysate) A: JurKat 5% SDS PAGE; antibody diluted at 1:1000. 0.1 mL Log in to see 7 to 9 Days
$447.56
Details
Human Rabbit Alexa Fluor 594 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Mouse Rabbit Un-conjugated ICC, IHC, IP, WB 100 μg Log in to see 15 to 18 Days
$360.00
Details

ABCB11 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-ABCB11 Antibodies

  1. Human Polyclonal ABCB11 Primary Antibody for IHC, IHC (p) - ABIN4277166 : Sambrotta, Strautnieks, Papouli, Rushton, Clark, Parry, Logan, Newbury, Kamath, Ling, Grammatikopoulos, Wagner, Magee, Sokol, Mieli-Vergani, Smith, Johnson, McClean, Simpson, Knisely, Bull, Thompson: Mutations in TJP2 cause progressive cholestatic liver disease. in Nature genetics 2014 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal ABCB11 Primary Antibody for IHC (p), WB - ABIN390059 : Strautnieks, Bull, Knisely, Kocoshis, Dahl, Arnell, Sokal, Dahan, Childs, Ling, Tanner, Kagalwalla, Németh, Pawlowska, Baker, Mieli-Vergani, Freimer, Gardiner, Thompson: A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis. in Nature genetics 1998 (PubMed)
    Show all 3 Pubmed References

More Antibodies against ABCB11 Interaction Partners

Rainbow Trout (Oncorhynchus mykiss) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11 (ABCB11) interaction partners

  1. Data show the gene expression profiling of ABC (show ABCB6 Antibodies) transporters in seven tissues.

  2. cloned one partial and two full gene sequences, which show high degree of identity with mammalian Pgp1 (ABCB1 (show ABCB1 Antibodies)), BSEP (ABCB11) and MRP2 (ABCC2 (show ABCC2 Antibodies)) efflux transporters and found identical relative expression patterns for both liver and primary hepatocytes

Human ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11 (ABCB11) interaction partners

  1. Patients with a confirmed ABCB11 or tight junction protein 2 (show TJP2 Antibodies) gene mutation (n = 7) had a minimally detectable THBA proportion (0.23-2.99% of total BAs). Three patients with an ATP8B1 (show ATP8B1 Antibodies) mutation had an elevated THBA proportion (7.51-37.26%).

  2. By these complementary approaches, a set of ten novel BSEP interaction partners was identified. With the exception of radixin (show RDX Antibodies), all other interaction partners were integral or membrane-associated proteins including proteins of the early secretory pathway and the bile acyl-CoA synthetase (show SLC27A5 Antibodies), the second to last, ER-associated enzyme of bile salt synthesis

  3. Among the Han individuals aged over 40 years in Hunan, China, genotype CC or CT of BSEP gene SNP rs2287622 may correlate with higher risk of chronic hepatitis C in comparison with genotype TT.

  4. Case Reports: late onset progressive familial intrahepatic cholestasis 2 secondary to novel ABCB11 mutations.

  5. Negative immunoreaction of BSEP was found in the majority of the progressive familial intrahepatic cholestasis (PFIC (show ATP8B1 Antibodies)) group. Nonetheless, the negative immunoreaction was demonstrated in a considerable number of the non-PFIC (show ATP8B1 Antibodies) group.BSEP immunoreaction was negative in the majority (82.4%) of PFIC2 but in none of the two patients with PFIC1 (show ATP8B1 Antibodies).

  6. The results revealed that functional impairment of BSEP predisposes the cells to altered BA disposition and is a susceptive factor to drug-induced cholestatic injury.

  7. Results identified six novel mutations (PKHD1 (show PKHD1 Antibodies): p.Thr777Met, p.Tyr2260Cys; ABCB11: p.Val1112Phe, c.611+1G > A, p.Gly628Trpfs*3 and NPC1 (show NPC1 Antibodies): p.Glu391Lys) for the diagnostic of inherited infantile cholestatic disorders.

  8. Report highly specific expression of BSEP and MDR3 (show ABCB4 Antibodies) in hepatocellular carcinoma.

  9. GGT levels in patients with ATP8B1 or ABCB11 deficiency varied with age. The peak GGT value was <70U/L in the 2nd~6th month of life, <60U/L in the 7th~12th month and <50U/L beyond one year

  10. methods that can be used to assess and quantify BSEP inhibition, and key gaps in our current understanding of the relationship between this process and DILI, are discussed

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11 (ABCB11) interaction partners

  1. Isoniazid/rifampicin administration significantly down-regulated the expression of hepatic bile acids transporters Ntcp (show SLC10A1 Antibodies) and Bsep in liver.

  2. mechanism of increased biliary lipid secretion in Bsep-/- mice is based on increased expression of the responsible canalicular transporter proteins.

  3. LKB1 (show STK11 Antibodies)/AMPK (show PRKAA1 Antibodies) and PKA control ABCB11 trafficking and polarization in hepatocytes.

  4. CA feeding of Bsep (-/-) mice increased hepatic Cyp3a11 protein levels.

  5. FXR (show NR1H4 Antibodies) regulates BSEP in an isoform-dependent and species-specific manner

  6. Ursodeoxycholic acid fed to abcb11-/- mice caused liver damage and the appearance of biliary tetra- and penta-hydroxy bile acids.

  7. Hepatic Abcb11 overexpression in mice increases the conservation of bile acids within the enterohepatic circulation.

  8. The authors show that two of these transporters, ABCB11 and ATP8B1 (show ATP8B1 Antibodies), are functional targets of miR (show MLXIP Antibodies)-33, a micro-RNA that is expressed from within an intron of SREBP-2 (show SREBF2 Antibodies).

  9. Abcb11 deficiency induces cholestasis coupled to impaired beta-fatty acid oxidation in mice.

  10. hyperosmotic cholestasis is triggered by a NADPH oxidase (show NOX1 Antibodies)-driven reactive oxygen species formation that mediates Fyn (show FYN Antibodies)-dependent retrieval of the Mrp2 (show ABCC2 Antibodies) and Bsep from the canalicular membrane, which may involve an increased cortactin (show CTTN Antibodies) phosphorylation.

ABCB11 Antigen Profile

Protein Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.

Gene names and symbols associated with ABCB11

  • ATP-binding cassette, sub-family B (MDR/TAP), member 11 (ABCB11) antibody
  • ATP-binding cassette, sub-family B (MDR/TAP), member 11 (abcb11) antibody
  • bile salt export pump (EDI_111220) antibody
  • bile salt export pump (EDI_272930) antibody
  • bile salt export pump (abcb11) antibody
  • ATP-binding cassette, sub-family B (MDR/TAP), member 11 (Abcb11) antibody
  • ATP-binding cassette, subfamily B (MDR/TAP), member 11 (Abcb11) antibody
  • ABC16 antibody
  • ABCB11 antibody
  • BRIC2 antibody
  • BSEP antibody
  • BSEP/SPGP antibody
  • Lith1 antibody
  • PFIC-2 antibody
  • PFIC2 antibody
  • PGY4 antibody
  • Spgp antibody

Protein level used designations for ABCB11

ATP-binding cassette, sub-family B (MDR/TAP), member 11 , bile salt export pump , bile salt export pump-like , ABC member 16, MDR/TAP subfamily , ATP-binding cassette sub-family B member 11 , progressive familial intrahepatic cholestasis 2 , sister p-glycoprotein , ATP-binding cassette, sub-family B, member 11 , sister of P-glycoprotein , liver bile salt export pump

GENE ID SPECIES
424170 Gallus gallus
470717 Pan troglodytes
488390 Canis lupus familiaris
531150 Bos taurus
100024107 Monodelphis domestica
100052359 Equus caballus
100083318 Ornithorhynchus anatinus
100404882 Callithrix jacchus
100454135 Pongo abelii
100473353 Ailuropoda melanoleuca
100489744 Xenopus (Silurana) tropicalis
100518154 Sus scrofa
100543935 Meleagris gallopavo
100565276 Anolis carolinensis
100590891 Nomascus leucogenys
5879080 Entamoeba dispar SAW760
5914265 Entamoeba dispar SAW760
100136688 Oncorhynchus mykiss
100337637 Cavia porcellus
8647 Homo sapiens
27413 Mus musculus
100008767 Oryctolagus cuniculus
83569 Rattus norvegicus
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