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The protein encoded by ABCC1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ABCC1 Kits (28) and ABCC1 Proteins (11) and many more products for this protein.
Showing 10 out of 70 products:
Human Polyclonal ABCC1 Primary Antibody for IHC (p), WB - ABIN3044230
Wang, Zhao, Wu, He, Qu, Zhao, Zhao, Li, Wang: Mechanistic analysis of taxol-induced multidrug resistance in an ovarian cancer cell line. in Asian Pacific journal of cancer prevention : APJCP 2013
Show all 2 Pubmed References
Monoclonal ABCC1 Primary Antibody for IF, WB - ABIN534097
Chen, Yang, Li, Zhang: The amino terminus of the human multidrug resistance transporter ABCC1 has a U-shaped folding with a gating function. in The Journal of biological chemistry 2006
Human Monoclonal ABCC1 Primary Antibody for FACS - ABIN4898742
Keshet, Goldstein, Itzhaki, Cesarkas, Shenhav, Yakirevitch, Treves, Schachter, Amariglio, Rechavi: MDR1 expression identifies human melanoma stem cells. in Biochemical and biophysical research communications 2008
Human Monoclonal ABCC1 Primary Antibody for FACS - ABIN4898743
Takahashi, Shibata, Oba, Ishikawa, Yoshikawa, Tatsunami, Takahashi, Tampo: Multidrug-resistance-associated protein plays a protective role in menadione-induced oxidative stress in endothelial cells. in Life sciences 2009
Human Monoclonal ABCC1 Primary Antibody for CyTOF, FACS - ABIN4900819
Fiskus, Rao, Fernandez, Herger, Yang, Chen, Kolhe, Mandawat, Wang, Joshi, Eaton, Lee, Atadja, Peiper, Bhalla: Molecular and biologic characterization and drug sensitivity of pan-histone deacetylase inhibitor-resistant acute myeloid leukemia cells. in Blood 2008
These results show that multidrug resistant leukemia cell microparticle regulation of ABCC1 in recipient cells is governed by the transfer of both miR (show MLXIP Antibodies)-326 and ABCB1 (show ABCB1 Antibodies) from donor cells
Higher expression of ABCG2 (show ABCG2 Antibodies) and MRP1 (show MDM4 Antibodies), and lower expression of CK19 (show KRT19 Antibodies) in papillary thyroid carcinomas with a solid component were associated with higher tumor recurrence rate and shorter disease-free survival.
Visfatin (show NAMPT Antibodies) increases the nuclear translocation of Akt (show AKT1 Antibodies) and its binding with ABCC1. These data showed that visfatin (show NAMPT Antibodies) can decrease doxorubicin sensitivity of Non-small-cell lung cancer cells via activation of Akt (show AKT1 Antibodies)/MRP1 (show MDM4 Antibodies).
Studied hedgehog (show SHH Antibodies) signaling effect thru ATP-binding cassette (ABC (show ABCB6 Antibodies)) transporters in hepatoma drug sensitivity. Results suggest Hedgehog (show SHH Antibodies) signaling transcription factor Gli-2 (show GLI2 Antibodies) to be the primary regulator for drug sensitivity of hepatoma through the ABCC1 transporter.
This study demonstrated that mitochondrial MRP-1 (show MDM4 Antibodies) is expressed in the outer mitochondrial membrane and is a client protein of HSP90beta (show HSP90AB1 Antibodies).
High ABCC1 expression is associated with hepatic fibrosis.
This study shows direct binding between MRP1 (show MDM4 Antibodies) Linker 1 (L1MRP1) domain and alpha- and beta-tubulin (show TUBB Antibodies) subunits, using a scanning peptide approach
In summary, chaetominine strongly reverses drug resistance by interfering with the PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies)/Nrf2 (show GABPA Antibodies) signaling, resulting in reduction of MRP1 (show MDM4 Antibodies)-mediated drug efflux and induction of Bax (show BAX Antibodies)/Bcl-2 (show BCL2 Antibodies)-dependent apoptosis in an ADR (show AKR1B1 Antibodies)-resistant K562/Adr (show AKR1B1 Antibodies) leukemia cell line.
cross-talk between MRP1 (show MDM4 Antibodies) glycosylation and phosphorylation occurs.
meta-analysis results strongly suggest that MRP1 (show MDM4 Antibodies) is overexpressed in both neurons and astrocytes of intractable epilepsy patients, inhibition of MRP1 (show MDM4 Antibodies) may enhance antiepileptic drug efficacy by increasing local drug availability
Loss of ABCC1 expression is associated with neonatal hyperbilirubinemia.
Data, including data from studies in knockout mice, suggest that Mrp1 is involved in development of vascular endothelial dysfunction in diabetic angiopathy; Mrp1 appears to be required for oxidative stress in endothelial cells due to hyperglycemia.
Oxidant-enriched Tumorigenic Endothelial Cells (EOMA) cells survive a heavy oxidant burden by rapid efflux of GSSG, which is lethal if trapped within the cell. A hyperactive MRP-1 system for GSSG efflux acts as a critical survival factor for these cells, making it a potential target for EOMA therapeutics.
P-gp, Bcrp, Mrp1 and Mrp4 are differentially expressed at the outer and inner blood retinal barrier, resulting in an altered ability to limit substrate distribution at the retina as compared with the blood brain barrier
Lentivirus-based RNAi stably knocks down the expression of the Mrp1 gene in the established TM4 (show TPM4 Antibodies) sertoli cell line.
neprilysin (show MME Antibodies) x ABCC1 double-deficient mice present a new model for early effects of amyloid-beta-related mild cognitive impairment that allows investigations without artificial overexpression of inherited Alzheimer's disease genes
Expression of apoA-I (show APOA1 Antibodies) or ABCA1 (show ABCA1 Antibodies) can reduce steatosis by decreasing lipid storage in hepatocytes through lipid transport and may also reduce endoplasmic reticulum stress, further lessening hepatic steatosis
Loss of Mrp1 coupled with reductions in steroid hormone levels leads to alterations in extrahepatic phase I, phase II and phase III metabolizing enzymes in a tissue-specific manner.
Cd or H(2)O(2) exposure increased the expression of key transport genes, Mrp1 and Mrp2 (show ABCC2 Antibodies), in WT cells but not in metallothionein (show MT Antibodies)-null cells.
These results identify Mrp1 as the transporter essential for S1P (show S1PR1 Antibodies) efflux from the endothelial cells and thus for inside-out S1P (show S1PR1 Antibodies) signaling to P-glycoprotein at the blood-brain and blood-spinal cord barriers.
Using electron cryomicroscopy, authors determined the molecular structures of bovine MRP1 in two conformations: an apo (show C9orf3 Antibodies) form at 3.5 A without any added substrate and a complex form at 3.3 A with one of its physiological substrates, leukotriene C4; structures show that by forming a single bipartite binding site, MRP1 can recognize a of substrates with different chemical structures.
P-gp (show ABCB4 Antibodies), Bcrp (show ABCG2 Antibodies) and Mrp1 are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown.
ATP-binding cassette transporter variant ABCC1delta-ex13
, ATP-binding cassette transporter variant ABCC1delta-ex13&14
, ATP-binding cassette transporter variant ABCC1delta-ex25
, ATP-binding cassette transporter variant ABCC1delta-ex25&26
, LTC4 transporter
, leukotriene C(4) transporter
, multidrug resistance-associated protein 1
, ATP-binding cassette, sub-family C (CFTR/MRP), member 1a
, ATP-binding cassette, sub-family C (CFTR/MRP), member 1b
, multiple drug resistance-associated protein
, ATP-binding cassette sub-family C member 1
, multidrug resistance protein 1
, ATP-binding cassette sub-family C ( CFTR/MRP) member 1a
, ATP-binding cassette, sub-family C (CFTR/MRP), member 1