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The protein encoded by ABCG5 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ABCG5 Antibodies (45) and ABCG5 Kits (1) and many more products for this protein.
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ABCG5 gene variants were not associated with cholelithiasis in patients with Gaucher disease type 1.
Genetic variations in ABCG5, CYP7A1 (show CYP7A1 Proteins), and DHCR7 (show DHCR7 Proteins) may contribute to differing responses of serum cholesterol to dairy intake among healthy adults.
ABCG5 Gene Variants are associated with Sitosterolemia and Familial Mediterranean Fever (show MEFV Proteins).
first case of a Mexican family with sitosterolemia carrying two new ABCG5 gene mutations
Genetic polymorphism within the ABCG5 gene is a risk factor for diabetes.
crystallization in lipid bilayers to determine the X-ray structure of human G5G8 in a nucleotide-free state at 3.9 A resolution, generating the first atomic model of an ABC (show ABCB6 Proteins) sterol transporter
ATP-binding cassette (ABC (show ABCB6 Proteins)) transporters G5 (ABCG5) and G8 (ABCG8 (show ABCG8 Proteins)) form an obligate heterodimer that limits intestinal absorption and facilitates biliary secretion of cholesterol and phytosterols.
ABCG5/8 variants are associated with susceptibility to coronary heart disease.
Sitosterolemia is caused by a genetic defect of sterolins (ABCG5/ABCG8 (show ABCG8 Proteins)) mapped to the STSL locus. Polymorphic variations in STSL have been linked to lipid levels and gallstone disease
HRD1 (show SYVN1 Proteins) and RMA1 may therefore be negative regulators of disease-associated transporter ABCG5/ABCG8 (show ABCG8 Proteins).
high expression levels of both ATP-binding cassette sub-family G member 5 and 8 (ABCG5 and ABCG8 (show ABCG8 Proteins)) were present in bovine liver and digestive tract samples, and in the mammary gland
The ABCG5/G8-independent pathway plays an important role in regulating biliary cholesterol secretion, and gallstone formation, which works independently of the ABCG5/G8 pathway.
ABCG5/G8 mediate mass biliary cholesterol secretion but not from a reverse cholesterol transport-relevant pool.
AdGRP78 reduced expression of lipogenic genes and plasma triglycerides in the db/db (show LEPR Proteins) strain. Both G5 and G8 protein levels increased as did total biliary cholesterol
The data demonstrate that Abcg5/Abcg8 (show ABCG8 Proteins) deficiency reduces the uptake and secretion of both dietary triacylglycerols and cholesterol by the intestine, suggesting a novel role for the sterol transporter in the formation and secretion of chylomicrons.
Sitosterolemia is caused by a genetic defect of sterolins (ABCG5/ABCG8 (show ABCG8 Proteins)) mapped to the STSL (show ABCG8 Proteins) locus. Polymorphic variations in STSL (show ABCG8 Proteins) have been linked to lipid levels and gallstone disease
The absence of an ABCG5/ABCG8 (show ABCG8 Proteins) expression.
Mice with deficient Abcg2 have features of inflammatory DCM and that the reversibility of myocardial T cell infiltration provides a novel model for investigating the progression of myocardial fibrosis.
biliary cholesterol mass secretion under maximal bile salt-stimulated conditions is fully dependent on ABCG5/G8
This study is the first to report such toxic effects of phytosterol accumulation in ABCG5/G8 knockout mice.
The ability of triiodothyronine to stimulate the secretion of cholesterol into bile is largely mediated by the ABCG5/G8 complex.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia.
ATP-binding cassette, sub-family G (WHITE), member 5 (sterolin 1)
, ATP-binding cassette sub-family G member 5
, sterolin 1
, ATP-binding cassette transporter
, ATP-binding cassette, sub-family G (WHITE), member 5
, ATP-binding cassette sub-family G member 5-like
, ATP-binding cassette, subfamily G, member 5
, ATP-binding cassette sub-family G (WHITE) member 5 (sterolin 1)