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anti-ATPase, Ca++ Transporting, Cardiac Muscle, Fast Twitch 1 (ATP2A1) Antibodies

ATP2A1 encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. Additionally we are shipping ATP2A1 Kits (9) and ATP2A1 Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ATP2A1 11937 Q8R429
ATP2A1 116601 Q64578
ATP2A1 487 O14983
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Top anti-ATP2A1 Antibodies at antibodies-online.com

Showing 10 out of 63 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, WB WB Suggested Anti-ATP2A1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HT-29/A549/NIH-3T3 cells, using... 100 μg Log in to see 2 to 3 Days
$275.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB ATP2A1 Antibody (C-term) (ABIN1881089) flow cytometric analysis of K56... ATP2A1 Antibody (C-term) (ABIN1881089) flow cytometric analysis of K56... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Mouse Rabbit Un-conjugated IHC (p), WB Anti- ATP2A1 antibody, Western blotting All lanes: Anti ATP2A1  at 0.5... Anti- ATP2A1 antibody,IHC(P) IHC(P): Rat Skeletal Muscle Tissue 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Mouse Un-conjugated EIA, IF, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$566.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-SERCA1 ATPase antibody, IHC(P) IHC(P): Human Placenta Tissue Anti-SERCA1 ATPase antibody, IHC(P) IHC(P): Rat Skeletal Muscle Tissue 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to ATP2A1 on A-431 cell (ant... 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 8 to 10 Days
$451.00
Details
Cow Rabbit Un-conjugated IP, IHC, WB Immunohistochemical analysis of SERCA1 staining in human muscle formal... Western blot analysis of SERCA1 expression in A549 (A), mouse muscle (... 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details

ATP2A1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine) , , ,

Rat (Rattus) , , ,

Human , , , ,
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Top referenced anti-ATP2A1 Antibodies

  1. Human Polyclonal ATP2A1 Primary Antibody for FACS, IHC (p) - ABIN1881089 : Salanova, Schiffl, Blottner: Atypical fast SERCA1a protein expression in slow myofibers and differential S-nitrosylation prevented by exercise during long term bed rest. in Histochemistry and cell biology 2009 (PubMed)
    Show all 3 references for ABIN1881089

  2. Human Polyclonal ATP2A1 Primary Antibody for IHC, WB - ABIN2775280 : Hino, Kondo, Sekiya, Saito, Kanemoto, Murakami, Chihara, Aoki, Nakamori, Takahashi, Imaizumi: Molecular mechanisms responsible for aberrant splicing of SERCA1 in myotonic dystrophy type 1. in Human molecular genetics 2007 (PubMed)

  3. Human Polyclonal ATP2A1 Primary Antibody for ELISA, WB - ABIN1535321 : Zhang, Fujii, Phillips, Chen, Karpati, Yee, Schrank, Cornblath, Boylan, MacLennan: Characterization of cDNA and genomic DNA encoding SERCA1, the Ca(2+)-ATPase of human fast-twitch skeletal muscle sarcoplasmic reticulum, and its elimination as a candidate gene for Brody disease. in Genomics 1997 (PubMed)

More Antibodies against ATP2A1 Interaction Partners

Zebrafish ATPase, Ca++ Transporting, Cardiac Muscle, Fast Twitch 1 (ATP2A1) interaction partners

  1. The different forms of phospholamban (show PLN Antibodies) in zebrafish may provide a novel SERCA regulatory mechanism.

  2. study showed that accordian acc(dta5) mutants harbor a novel mutation in atp2a1; indicate the acc(dta5) mutation diminishes SERCA1 function to a greater degree than other acc alleles through haploinsufficient or dominant-negative molecular mechanisms

  3. encodes the sarco(endo)plasmic reticulum Ca2+-ATPase 1 (SERCA1), a Ca2 (show CA2 Antibodies)+ pump found in the muscle sarcoplasmic reticulum (SR) that is responsible for pumping Ca2 (show CA2 Antibodies)+ from the cytosol back to the SR

  4. concluded that the motility dysfunction in embryonic and larval accordion zebrafish stems directly from defective calcium transport in skeletal muscle due to mutation in SERCA rather than defective CNS drive.

Xenopus laevis ATPase, Ca++ Transporting, Cardiac Muscle, Fast Twitch 1 (ATP2A1) interaction partners

  1. Atp2a1/serca1 is expressed as soon as the end of gastrulation in a subset of the myod (show MYOD1 Antibodies)-positive cells, and later labels prospective slow muscle cells in the superficial part of the somite.

Pig (Porcine) ATPase, Ca++ Transporting, Cardiac Muscle, Fast Twitch 1 (ATP2A1) interaction partners

  1. Cell functions regulated by protein-protein interactions of the SERCA1a-sarcolipin (show SLN Antibodies) complex is accomplished via s-palmitoylation and s-oleoylation of sarcolipin (show SLN Antibodies).

  2. The changes in expression of SERCA1 potentially disturb the normal Ca2 (show CA2 Antibodies)+ channel as well as the balance of Ca2 (show CA2 Antibodies)+ homeostasis.

Rabbit ATPase, Ca++ Transporting, Cardiac Muscle, Fast Twitch 1 (ATP2A1) interaction partners

  1. Inhibition of the sarco/endoplasmic reticulum Ca2+-ATPase (show ATP2A3 Antibodies) (SERCA1) by rutin derivatives.

  2. Infrared spectroscopy was used to characterise recombinant sarcoplasmic reticulum Ca2+-ATPase (SERCA1a).

  3. Data show that biselyngbyasides (BLSs) bind to the pump SERCA1a calcium ATPase (show CA-P60A Antibodies) near the cytoplasmic surface of the transmembrane region.

  4. Cell functions regulated by protein-protein interactions of the SERCA1a-sarcolipin (show SLN Antibodies) complex is accomplished via s-palmitoylation and s-oleoylation of sarcolipin (show SLN Antibodies).

  5. Rescue of mutated SERCA1 to sarcoplasmic reticulum membrane can re-establish resting cytosolic Ca(2 (show CA2 Antibodies)+) concentration and prevent the appearance of pathological signs of cattle pseudomyotonia

  6. Conformation of the SERCA1A calcium ATPase (show CA-P60A Antibodies) in the presence of different lipids.

  7. Ca(2 (show CA2 Antibodies)+) and PLB (show PLN Antibodies) phosphorylation relieve SERCA (show ATP2A3 Antibodies)-PLB (show PLN Antibodies) inhibition by distinct mechanisms, but both are achieved primarily by structural changes within the SERCA (show ATP2A3 Antibodies)-PLB (show PLN Antibodies) complex, not by dissociation of that complex.

  8. Phosphorylated phospholamban (show PLN Antibodies) stabilizes a unique conformation of SERCA (show ATP2A3 Antibodies) that is characterized by a compact architecture.

  9. Data suggest some phytoestrogenic flavonoids cooperate to inhibit SERCA (show ATP2A3 Antibodies), alter ATP binding properties of SERCA (show ATP2A3 Antibodies), and alter phosphorylation/dephosphorylation of SERCA (show ATP2A3 Antibodies) by binding to several sites that are close to ATP binding site.

  10. Data suggest that phospholamban (show PLN Antibodies) PLN's conformational equilibrium is central to maintain sarcoplasmic reticulum Ca(2+)-ATPase (show CA-P60A Antibodies) SERCA's apparent Ca(2 (show CA2 Antibodies)+) affinity within a physiological window.

Mouse (Murine) ATPase, Ca++ Transporting, Cardiac Muscle, Fast Twitch 1 (ATP2A1) interaction partners

  1. Ebf3 (show EBF3 Antibodies) binds directly to the promoter of Atp2a1 and synergises with MyoD (show MYOD1 Antibodies) in the induction of Atp2a1

  2. Formalin evokes calcium transients from the endoplasmatic reticulum via SERCA1-dependent, TRPA1 (show TRPA1 Antibodies)-independent mechanism that may underlie formaldehyde-induced pan (show SUPT6H Antibodies)-neuronal excitation and subsequent inflammation.

  3. SERCA1b is considered to play an essential role in the regulation of [Ca2 (show CA2 Antibodies)+]i and its ab ovo gene silencing results in decreased skeletal muscle differentiation.

  4. Data show that in healthy transgenic mice, cardiac-specific sarcoplasmic reticulum calcium ATPase (show CA-P60A Antibodies) SERCA1a expression increased active cell-surface glucose transporter GLUT4 (show SLC2A4 Antibodies) and glucose uptake in the myocardium.

  5. Data suggest that the cardiac depressant properties of neuronostatin possibly associated with loss of sarcoplasmic reticulum Ca2+-ATPase SERCA (show ATP2A3 Antibodies) phosphorylation.

  6. Results indicated that sine oculis homeobox (show PRRX1 Antibodies) 1 (Six1 (show SIX1 Antibodies)) overexpression could significantly promote the expression of fast-type muscle genes Atp2a1, Srl (show SRL Antibodies), and Mylpf (show MYLPF Antibodies).

  7. Protein levels of CSQ1 (show CASQ1 Antibodies), SERCA1, and SERCA2 (show ATP2A2 Antibodies) are re-adjusted in skeletal muscles depending on the demands of diverse exercise training programs.

  8. dystrophic phenotype observed in delta-sarcoglycan (show SGCD Antibodies)-null (Sgcd (show SGCD Antibodies)(-/-)) mice and dystrophin (show DMD Antibodies) mutant mdx (show DMD Antibodies) mice is dramatically improved by skeletal muscle-specific (show EIF3K Antibodies) overexpression of sarcoplasmic reticulum Ca(2+) ATPase 1 (SERCA1)

  9. Sarcolipin (show SLN Antibodies) is a novel regulator of SERCA (show ATP2A3 Antibodies) pump activity, and its inhibitory effect can be reversed by beta-adrenergic agonists.

  10. The results indicate that SERCA (show ATP2A3 Antibodies) overexpression can reduce the *OH-induced contractile dysfunction in murine myocardium, whereas a reduced SR Ca(2+)-ATPase (show CA-P60A Antibodies) activity aggravates this injury.

Human ATPase, Ca++ Transporting, Cardiac Muscle, Fast Twitch 1 (ATP2A1) interaction partners

  1. Thus the human SERCA1b has a different expression pattern from that of rodents and it is associated with DM2 (show CNBP Antibodies).

  2. Formalin evokes calcium transients from the endoplasmatic reticulum via SERCA1-dependent, TRPA1 (show TRPA1 Antibodies)-independent mechanism that may underlie formaldehyde-induced pan (show SUPT6H Antibodies)-neuronal excitation and subsequent inflammation.

  3. We conclude that PLB (show PLN Antibodies) C-terminal residues are critical for localization, oligomerization, and regulatory function. In particular, the PLB (show PLN Antibodies) C terminus is an important determinant of the quaternary structure of the SERCA (show ATP2A3 Antibodies) regulatory complex.

  4. Aberrant splicing of SERCA1 may alter intracellular Ca(2 (show CA2 Antibodies)+) signalling in myotonic dystrophy 1 and 2 myotubes. The differing dysregulation of intracellular Ca(2 (show CA2 Antibodies)+) handling in DM1 (show DMPK Antibodies) and DM2 (show CNBP Antibodies) may explain their distinct sarcolemmal hyperexcitabilities.

  5. We performed a detailed study of SERCA1 protein expression in muscle of patients with BD and BS, and evaluated the alternative splicing of SERCA1 in primary cultures of normal human muscle

  6. These results indicate that PKC signaling is involved in the splicing of SERCA1 and provide new evidence for a link between alternative splicing and PKC signaling.

  7. both topology and function of PLN (show PLN Antibodies) are shaped by the interactions with lipids, which fine-tune the regulation of SERCA (show ATP2A3 Antibodies)

  8. Modeling of the inhibitory interaction of phospholamban (show PLN Antibodies) with the Ca2+ ATPase.

  9. regulation by sarcolipin's involvement in binding to transmembrane helices alone or in association with phospholamban (show PLN Antibodies)

  10. kinetic analysis of SERCA1 and SERCA2 (show ATP2A2 Antibodies) isoforms and the effects of mutation

Cow (Bovine) ATPase, Ca++ Transporting, Cardiac Muscle, Fast Twitch 1 (ATP2A1) interaction partners

  1. Results demonstrate that a cattle congenital pseudomyotonia is caused by a SERCA1 deficiency, resulting from a defect in the ATP2A1 gene

  2. Rescue of mutated SERCA1 to sarcoplasmic reticulum membrane can re-establish resting cytosolic Ca(2 (show CA2 Antibodies)+) concentration and prevent the appearance of pathological signs of cattle pseudomyotonia

  3. crystal structure of SERCA (show ATP2A3 Antibodies), crystallized in the E1 conformation and determined at 2.9A resolution

  4. Mutation in ATP2A1 is associated with congenital muscular dystony type 1

  5. study reports the identification of a missense mutation in ATP2A1 in congential pseudomytonia of Chianina cattle; mutation analysis of ATP2A1 exons revealed a perfectly associated missense mutation in exon 6 (c.491G>A) leading to p.Arg164His substitution

  6. In this study, we provide biochemical evidence for a selective deficiency in SERCA1 protein levels in sarcoplasmic reticulum membranes from Chianina cattle with congenital pseudomyotonia

ATP2A1 Antigen Profile

Protein Summary

This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in two transcript variants encoding different isoforms.

Gene names and symbols associated with ATP2A1

  • ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 (atp2a1) antibody
  • ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 (ATP2A1) antibody
  • ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 (Atp2a1) antibody
  • ATP2A antibody
  • ATP2A1 antibody
  • atp2a2 antibody
  • ATP2A3 antibody
  • atp2b antibody
  • ca-p60a antibody
  • cb279 antibody
  • dar antibody
  • serca antibody
  • Serca1 antibody
  • SERCA1a antibody
  • serca2 antibody
  • wu:cegs655 antibody
  • wu:fb17h11 antibody
  • wu:fb19b10 antibody
  • zgc:92110 antibody

Protein level used designations for ATP2A1

ATPase, Ca++ transporting, fast twitch 1 , acc , accordion , sarcoendoplasmic reticulum calcium ATPase , ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 , ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 , sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like , ATPase, Ca++ transporting, slow twitch 2 , sarcoplasmic/endoplasmic reticulum calcium ATPase 1 , ATPase, Ca++ transporting, ubiquitous , SERCA1 , SR Ca(2+)-ATPase 1 , calcium pump 1 , calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform , endoplasmic reticulum class 1/2 Ca(2+) ATPase

GENE ID SPECIES
260440 Danio rerio
454019 Pan troglodytes
479797 Canis lupus familiaris
613090 Xenopus (Silurana) tropicalis
708058 Macaca mulatta
100453755 Pongo abelii
446229 Xenopus laevis
100516962 Sus scrofa
100037716 Oryctolagus cuniculus
11937 Mus musculus
116601 Rattus norvegicus
487 Homo sapiens
518117 Bos taurus
396528 Gallus gallus
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