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ATPase, Ca++ Transporting, Cardiac Muscle, Fast Twitch 1 Proteins (ATP2A1)

ATP2A1 encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. Additionally we are shipping ATP2A1 Antibodies (63) and ATP2A1 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ATP2A1 11937 Q8R429
Rat ATP2A1 ATP2A1 116601 Q64578
ATP2A1 487 O14983
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Top ATP2A1 Proteins at antibodies-online.com

Showing 6 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

ATP2A1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
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Human , , ,
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More Proteins for ATPase, Ca++ Transporting, Cardiac Muscle, Fast Twitch 1 (ATP2A1) Interaction Partners

Zebrafish ATPase, Ca++ Transporting, Cardiac Muscle, Fast Twitch 1 (ATP2A1) interaction partners

  1. The different forms of phospholamban (show PLN Proteins) in zebrafish may provide a novel SERCA regulatory mechanism.

  2. study showed that accordian acc(dta5) mutants harbor a novel mutation in atp2a1; indicate the acc(dta5) mutation diminishes SERCA1 function to a greater degree than other acc alleles through haploinsufficient or dominant-negative molecular mechanisms

  3. encodes the sarco(endo)plasmic reticulum Ca2+-ATPase 1 (SERCA1), a Ca2 (show CA2 Proteins)+ pump found in the muscle sarcoplasmic reticulum (SR) that is responsible for pumping Ca2 (show CA2 Proteins)+ from the cytosol back to the SR

  4. concluded that the motility dysfunction in embryonic and larval accordion zebrafish stems directly from defective calcium transport in skeletal muscle due to mutation in SERCA rather than defective CNS drive.

Xenopus laevis ATPase, Ca++ Transporting, Cardiac Muscle, Fast Twitch 1 (ATP2A1) interaction partners

  1. Atp2a1/serca1 is expressed as soon as the end of gastrulation in a subset of the myod (show MYOD1 Proteins)-positive cells, and later labels prospective slow muscle cells in the superficial part of the somite.

Pig (Porcine) ATPase, Ca++ Transporting, Cardiac Muscle, Fast Twitch 1 (ATP2A1) interaction partners

  1. Cell functions regulated by protein-protein interactions of the SERCA1a-sarcolipin complex is accomplished via s-palmitoylation and s-oleoylation of sarcolipin.

  2. The changes in expression of SERCA1 potentially disturb the normal Ca2 (show CA2 Proteins)+ channel as well as the balance of Ca2 (show CA2 Proteins)+ homeostasis.

Rabbit ATPase, Ca++ Transporting, Cardiac Muscle, Fast Twitch 1 (ATP2A1) interaction partners

  1. Here we describe the methods to analyze these processes in the transport cycle with a representative member of P-type ATPase family, SERCA1a, sarco(endo)plasmic reticulum Ca(2+)-ATPase

  2. oligonucleotide-based drugs could be used to fine-tune SERCA (show ATP2A3 Proteins) function to counterbalance the extent of the pathological insults.

  3. Inhibition of the sarco/endoplasmic reticulum Ca2+-ATPase (show ATP2A3 Proteins) (SERCA1) by rutin derivatives.

  4. Infrared spectroscopy was used to characterise recombinant sarcoplasmic reticulum Ca2+-ATPase (SERCA1a).

  5. Data show that biselyngbyasides (BLSs) bind to the pump SERCA1a calcium ATPase near the cytoplasmic surface of the transmembrane region.

  6. Cell functions regulated by protein-protein interactions of the SERCA1a-sarcolipin complex is accomplished via s-palmitoylation and s-oleoylation of sarcolipin.

  7. Rescue of mutated SERCA1 to sarcoplasmic reticulum membrane can re-establish resting cytosolic Ca(2 (show CA2 Proteins)+) concentration and prevent the appearance of pathological signs of cattle pseudomyotonia

  8. Conformation of the SERCA1A calcium ATPase in the presence of different lipids.

  9. Ca(2 (show CA2 Proteins)+) and PLB (show PLN Proteins) phosphorylation relieve SERCA (show ATP2A3 Proteins)-PLB (show PLN Proteins) inhibition by distinct mechanisms, but both are achieved primarily by structural changes within the SERCA (show ATP2A3 Proteins)-PLB (show PLN Proteins) complex, not by dissociation of that complex.

  10. Phosphorylated phospholamban (show PLN Proteins) stabilizes a unique conformation of SERCA (show ATP2A3 Proteins) that is characterized by a compact architecture.

Mouse (Murine) ATPase, Ca++ Transporting, Cardiac Muscle, Fast Twitch 1 (ATP2A1) interaction partners

  1. CAPN3 (show CAPN3 Proteins) deficiency leads to degradation of SERCA (show ATP2A3 Proteins) proteins and Ca2 (show CA2 Proteins)+ dysregulation in the skeletal muscle.

  2. Ebf3 (show EBF3 Proteins) binds directly to the promoter of Atp2a1 and synergises with MyoD (show MYOD1 Proteins) in the induction of Atp2a1

  3. Formalin evokes calcium transients from the endoplasmatic reticulum via SERCA1-dependent, TRPA1-independent mechanism that may underlie formaldehyde-induced pan-neuronal excitation and subsequent inflammation.

  4. SERCA1b is considered to play an essential role in the regulation of [Ca2 (show CA2 Proteins)+]i and its ab ovo gene silencing results in decreased skeletal muscle differentiation.

  5. Data show that in healthy transgenic mice, cardiac-specific sarcoplasmic reticulum calcium ATPase SERCA1a expression increased active cell-surface glucose transporter GLUT4 (show SLC2A4 Proteins) and glucose uptake in the myocardium.

  6. Data suggest that the cardiac depressant properties of neuronostatin possibly associated with loss of sarcoplasmic reticulum Ca2+-ATPase SERCA (show ATP2A3 Proteins) phosphorylation.

  7. Results indicated that sine oculis homeobox (show PRRX1 Proteins) 1 (Six1 (show SIX1 Proteins)) overexpression could significantly promote the expression of fast-type muscle genes Atp2a1, Srl (show SRL Proteins), and Mylpf (show MYLPF Proteins).

  8. Protein levels of CSQ1 (show CASQ1 Proteins), SERCA1, and SERCA2 (show ATP2A2 Proteins) are re-adjusted in skeletal muscles depending on the demands of diverse exercise training programs.

  9. dystrophic phenotype observed in delta-sarcoglycan (show SGCD Proteins)-null (Sgcd (show SGCD Proteins)(-/-)) mice and dystrophin (show DMD Proteins) mutant mdx (show DMD Proteins) mice is dramatically improved by skeletal muscle-specific (show EIF3K Proteins) overexpression of sarcoplasmic reticulum Ca(2+) ATPase 1 (SERCA1)

  10. Sarcolipin is a novel regulator of SERCA (show ATP2A3 Proteins) pump activity, and its inhibitory effect can be reversed by beta-adrenergic agonists.

Human ATPase, Ca++ Transporting, Cardiac Muscle, Fast Twitch 1 (ATP2A1) interaction partners

  1. CAPN3 (show CAPN3 Proteins) deficiency leads to degradation of SERCA (show ATP2A3 Proteins) proteins and Ca2 (show CA2 Proteins)+ dysregulation in the skeletal muscle.

  2. The sphingolipid sphingosine increases the [Ca(2+)]i by inhibiting the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA), in a similar manner to thapsigargin (Tg), a specific inhibitor of this Ca(2+) pump.

  3. Thus the human SERCA1b has a different expression pattern from that of rodents and it is associated with DM2 (show CNBP Proteins).

  4. Formalin evokes calcium transients from the endoplasmatic reticulum via SERCA1-dependent, TRPA1-independent mechanism that may underlie formaldehyde-induced pan-neuronal excitation and subsequent inflammation.

  5. We conclude that PLB (show PLN Proteins) C-terminal residues are critical for localization, oligomerization, and regulatory function. In particular, the PLB (show PLN Proteins) C terminus is an important determinant of the quaternary structure of the SERCA (show ATP2A3 Proteins) regulatory complex.

  6. Aberrant splicing of SERCA1 may alter intracellular Ca(2 (show CA2 Proteins)+) signalling in myotonic dystrophy 1 and 2 myotubes. The differing dysregulation of intracellular Ca(2 (show CA2 Proteins)+) handling in DM1 (show DMPK Proteins) and DM2 (show CNBP Proteins) may explain their distinct sarcolemmal hyperexcitabilities.

  7. We performed a detailed study of SERCA1 protein expression in muscle of patients with BD and BS, and evaluated the alternative splicing of SERCA1 in primary cultures of normal human muscle

  8. These results indicate that PKC signaling is involved in the splicing of SERCA1 and provide new evidence for a link between alternative splicing and PKC signaling.

  9. both topology and function of PLN (show PLN Proteins) are shaped by the interactions with lipids, which fine-tune the regulation of SERCA (show ATP2A3 Proteins)

  10. Modeling of the inhibitory interaction of phospholamban (show PLN Proteins) with the Ca2+ ATPase.

Cow (Bovine) ATPase, Ca++ Transporting, Cardiac Muscle, Fast Twitch 1 (ATP2A1) interaction partners

  1. Results demonstrate that a cattle congenital pseudomyotonia is caused by a SERCA1 deficiency, resulting from a defect in the ATP2A1 gene

  2. Rescue of mutated SERCA1 to sarcoplasmic reticulum membrane can re-establish resting cytosolic Ca(2 (show CA2 Proteins)+) concentration and prevent the appearance of pathological signs of cattle pseudomyotonia

  3. crystal structure of SERCA (show ATP2A3 Proteins), crystallized in the E1 conformation and determined at 2.9A resolution

  4. Mutation in ATP2A1 is associated with congenital muscular dystony type 1

  5. study reports the identification of a missense mutation in ATP2A1 in congential pseudomytonia of Chianina cattle; mutation analysis of ATP2A1 exons revealed a perfectly associated missense mutation in exon 6 (c.491G>A) leading to p.Arg164His substitution

  6. In this study, we provide biochemical evidence for a selective deficiency in SERCA1 protein levels in sarcoplasmic reticulum membranes from Chianina cattle with congenital pseudomyotonia

ATP2A1 Protein Profile

Protein Summary

This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in two transcript variants encoding different isoforms.

Gene names and symbols associated with ATP2A1

  • ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 (atp2a1)
  • ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 (ATP2A1)
  • ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 (Atp2a1)
  • ATP2A protein
  • ATP2A1 protein
  • atp2a2 protein
  • ATP2A3 protein
  • atp2b protein
  • ca-p60a protein
  • cb279 protein
  • dar protein
  • serca protein
  • Serca1 protein
  • SERCA1a protein
  • serca2 protein
  • wu:cegs655 protein
  • wu:fb17h11 protein
  • wu:fb19b10 protein
  • zgc:92110 protein

Protein level used designations for ATP2A1

ATPase, Ca++ transporting, fast twitch 1 , acc , accordion , sarcoendoplasmic reticulum calcium ATPase , ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 , ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 , sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like , ATPase, Ca++ transporting, slow twitch 2 , sarcoplasmic/endoplasmic reticulum calcium ATPase 1 , ATPase, Ca++ transporting, ubiquitous , SERCA1 , SR Ca(2+)-ATPase 1 , calcium pump 1 , calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform , endoplasmic reticulum class 1/2 Ca(2+) ATPase

GENE ID SPECIES
260440 Danio rerio
454019 Pan troglodytes
479797 Canis lupus familiaris
613090 Xenopus (Silurana) tropicalis
708058 Macaca mulatta
100453755 Pongo abelii
446229 Xenopus laevis
100516962 Sus scrofa
100037716 Oryctolagus cuniculus
11937 Mus musculus
116601 Rattus norvegicus
487 Homo sapiens
518117 Bos taurus
396528 Gallus gallus
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