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ATPase, Ca++ Transporting, Plasma Membrane 4 (ATP2B4) ELISA Kits

The protein encoded by ATP2B4 belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. Additionally we are shipping ATP2B4 Antibodies (30) and ATP2B4 Proteins (10) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human ATP2B4 ATP2B4 493 P23634
Anti-Rat ATP2B4 ATP2B4 29600 Q64542
Anti-Mouse ATP2B4 ATP2B4 381290  
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More ELISA Kits for ATP2B4 Interaction Partners

Cow (Bovine) ATPase, Ca++ Transporting, Plasma Membrane 4 (ATP2B4) interaction partners

  1. Switch of PMCA4 splice variants in bovine epididymis results in altered isoform expression during functional sperm maturation.

  2. results indicate possible functional compartmentalization of PMCA in bull sperm membranes and point to a presumptive, interaction partner of Ca(2+)-ATPase and PDC-109.

  3. thermodynamic analysis of mitochondrial F1 ATPase (show DNAH8 ELISA Kits)

Human ATPase, Ca++ Transporting, Plasma Membrane 4 (ATP2B4) interaction partners

  1. RNA sequencing identified a novel ATPase (show DNAH8 ELISA Kits), Ca2 (show CA2 ELISA Kits)+ transporting, plasma membrane 4(ATP2B4)-protein kinase C-alpha (PRKCA (show PKCa ELISA Kits)) fusion transcript.

  2. our data show that CD147 interacts via its immunomodulatory domains with PMCA4 to bypass TCR proximal signaling and inhibit IL-2 (show IL2 ELISA Kits) expression.

  3. We also nominate a new candidate gene in congenital arrhythmia, ATP2B4, and provide experimental evidence of a regulatory role for variants discovered using this framework.

  4. p.R268Q mutation in PMCA4 resulted in functional changes in calcium homeostasis in human neuronal cells. This suggests that calcium dysregulation may be associated with the pathogenesis of Familial spastic paraplegia

  5. The slowly activating PMCA4b isoform produced long-lasting Ca2 (show CA2 ELISA Kits)+ oscillations in response to store-operated Ca2 (show CA2 ELISA Kits)+ entry.

  6. While PMCA1b (show ATP2B1 ELISA Kits) has a housekeeping function in colon cancer cells, PMCA4b participates in the reorganization of the calcium signaling machinery during cell differentiation.

  7. Mechanism of PMCA4 that creates lipid asymmetry is well understood in terms of ATP hydrolysis; molecular models exist for trajectory taken by phospholipid substrates through the enzyme. [review-like article]

  8. Calcium dysregulation resulting from a novel missense mutation (c.803G>A, p.R268Q) in the PMCA4 (ATP2B4) gene may be associated with the pathogenesis of familial spastic paraplegia.

  9. PMCA4 inhibits the activation of the calcineurin/NFAT pathway on VEGF stimulation of endothelial cells, leading to a significant attenuation of VEGF-mediated angiogenesis.

  10. A significant relationship between ATP2B4 gene expression and the tumor location was detected in patients with rectum tumors.

Pig (Porcine) ATPase, Ca++ Transporting, Plasma Membrane 4 (ATP2B4) interaction partners

  1. lipid rafts may contribute to the interaction of PMCA4 with proteins involved in Ca2 (show CA2 ELISA Kits)+ signaling at discrete functional positions on the synaptic nerve terminals

Mouse (Murine) ATPase, Ca++ Transporting, Plasma Membrane 4 (ATP2B4) interaction partners

  1. Electron microscopy demonstrated Pmca4 localization in distal nephron cells at both the basolateral membrane and intracellular perinuclear compartments but not submembranous vesicles

  2. Findings indicate an important regulation of plasma membrane Ca(2+)-ATPase (show ATP2B2 ELISA Kits) (PMCA) by Homer2 (show HOMER2 ELISA Kits) protein that has a central role on PMCA-mediated Ca(2 (show CA2 ELISA Kits)+) signaling in parotid acinar cells.

  3. PMCA4 inhibits the activation of the calcineurin/NFAT pathway on VEGF stimulation of endothelial cells, leading to a significant attenuation of VEGF-mediated angiogenesis.

  4. this study concludes that Ca(2 (show CA2 ELISA Kits)+) efflux activity of PMCA4 underlies G1 progression in vascular smooth muscle cells and that PMCA4a and PMCA4b differentially regulate specific downstream mediators.

  5. Ca(2 (show CA2 ELISA Kits)+) homeostasis in sperm is maintained by the relative ratios of CASK (show CASK ELISA Kits)-PMCA4b and CASK (show CASK ELISA Kits)-JAM-A (show F11R ELISA Kits) interactions

  6. Plasma membrane calcium pump (show ATP2B2 ELISA Kits) (PMCA) isoform 4 is targeted to the apical membrane by the w-splice insert from PMCA2 (show ATP2B2 ELISA Kits).

  7. Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase (show NOS1 ELISA Kits) complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain.

  8. expression of Atp2b4 significantly decreased in enamel organs from Mmp20 (show MMP20 ELISA Kits)(-/-) mice. A feedback mechanism regulates ion-responsive gene expression during enamel development.

  9. PMCA4 was found to be selectively expressed in both synaptic layers of the retina

  10. G1/S-specific PMCA4 repression in proliferating VSMC is brought about by c-Myb (show MYB ELISA Kits) and CaMK-II (show CAMK2B ELISA Kits)

ATP2B4 Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with ATP2B4

  • ATPase, Ca++ transporting, plasma membrane 4 (ATP2B4) antibody
  • ATPase, Ca++ transporting, plasma membrane 2 (ATP2B2) antibody
  • ATPase, Ca++ transporting, plasma membrane 4 (atp2b4) antibody
  • ATPase, Ca++ transporting, plasma membrane 4 (Atp2b4) antibody
  • ATP2B1 antibody
  • atp2b2 antibody
  • atp2b3 antibody
  • ATP2B4 antibody
  • mxra1 antibody
  • Pmca4 antibody
  • pmca4b antibody
  • pmca4x antibody
  • zgc:152801 antibody

Protein level used designations for ATP2B4

plasma membrane calcium ATPase 4 , plasma membrane calcium-transporting ATPase 4 , ATPase, Ca++ transporting, plasma membrane 4 , plasma membrane calcium-transporting ATPase 2 , plasma membrane calcium-transporting ATPase 4-like , matrix-remodeling-associated protein 1 , sarcolemmal calcium pump , plasma membrane Ca2+-ATPases 4 , plasma membrane calcium ATPase , plasma membrane calcium pump , pmca4 , ATPase, Ca++ transporting, plasma membrane 3 , plasma membrane calcium ATPase 3 , ATPase, Ca++ transporting, plasma membrane 4 ATP synthase, H+ transporting, mitochondrial F1

GENE ID SPECIES
457646 Pan troglodytes
574317 Macaca mulatta
613800 Bos taurus
100049920 Equus caballus
100410901 Callithrix jacchus
100089144 Ornithorhynchus anatinus
100446010 Pongo abelii
100558540 Anolis carolinensis
100603540 Nomascus leucogenys
493 Homo sapiens
733701 Sus scrofa
29600 Rattus norvegicus
768304 Danio rerio
446855 Xenopus laevis
419934 Gallus gallus
403731 Canis lupus familiaris
282146 Bos taurus
100353865 Oryctolagus cuniculus
381290 Mus musculus
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