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ATPase, Ca++ Transporting, Type 2C, Member 1 Proteins (ATP2C1)

The protein encoded by ATP2C1 belongs to the family of P-type cation transport ATPases. Additionally we are shipping ATP2C1 Antibodies (86) and ATP2C1 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ATP2C1 27032 P98194
Rat ATP2C1 ATP2C1 170699  
ATP2C1 235574 Q80XR2
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Top ATP2C1 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

ATP2C1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for ATPase, Ca++ Transporting, Type 2C, Member 1 (ATP2C1) Interaction Partners

Human ATPase, Ca++ Transporting, Type 2C, Member 1 (ATP2C1) interaction partners

  1. Two novel ATP2C1 mutations have been found in two unrelated Chinese patients with Hailey-Hailey disease pedigree.

  2. Besides the level of functional ATP2C1 protein, levels of other ATPase proteins may influence expressivity of the disease and may also contribute to atypical presentations in three male members of the Hailey Hailey disease family.

  3. This is the first genetic report of HHD from Lebanon in which we identified three novel mutations in ATP2C1 and shed light on the molecular mechanisms and pathogenesis of HHD by linking stress signals like heat shock to the observed phenotypes

  4. We speculate that a novel pathogenic mechanism involving SPCA1, p63 (show RPE65 Proteins), and IRF6 (show IRF6 Proteins) may play a role in the skin lesions occurring in HHD.

  5. Data suggest that calcium ATPase ATP2C1 gene expression is influenced by an overlapping protein asteroid homolog 1 ASTE1 (show ASTE1 Proteins) gene.

  6. The CFL-1 (show VPS72 Proteins)-dependent recruitment of actin to SPCA1 following calcium influx is critical for secretory cargo sorting.

  7. Case Report: haploinsufficiency of ATP2C1 mutations is the causative mechanism of Hailey-Hailey disease.

  8. We report sibling cases of Hailey-Hailey disease with novel mutations in the ATP2C1 gene that showed unique and atypical clinical phenotypes mimicking seborrheic dermatitis, pemphigus vulgaris (show DSG3 Proteins), or pemphigus foliaceus (show DSG1 Proteins)

  9. A novel mutation is identified in ATP2C1 linked to Chinese patients with Hailey-Hailey disease.

  10. we report four novel mutations of the ATP2C1 gene involved in HHD, expanding the repertoire of ATP2C1 mutations underlying HHD.

Mouse (Murine) ATPase, Ca++ Transporting, Type 2C, Member 1 (ATP2C1) interaction partners

  1. The timing, magnitude of TMEM165 expression and its Golgi location supports a role for this Golgi Ca2 (show CA2 Proteins)+/H+ antiporter as a contributor to mammary Golgi calcium transport needs, in addition to the better-characterized roles of SPCA 1 and 2.

  2. loss of the Golgi Ca(2 (show CA2 Proteins)+) pump causes Golgi stress, expansion of the Golgi, increased apoptosis, and embryonic lethality and demonstrates that SPCA1 haploinsufficiency causes a genetic predisposition to cancer.

  3. The synthesized siPMR1 can significantly silence the expression of PMR1 and promote the secretion of insulin (show INS Proteins) in the islet cells in vitro.

  4. Impaired cellular divalent calcium ion Ca2 (show CA2 Proteins)+ homeostasis and/or the altered targeting of organellar proteins under conditions of SPCA1 knockdown highlight the importance of SPCA1 function for normal neural differentiation.

ATP2C1 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium ions. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with ATP2C1

  • ATPase, Ca++ transporting, type 2C, member 1 (ATP2C1)
  • ATPase, Ca++ transporting, type 2C, member 1 (atp2c1)
  • ATPase, Ca++ transporting, type 2C, member 1 (Atp2c1)
  • ATPase, Ca++-sequestering (Atp2c1)
  • 1700121J11Rik protein
  • ATP2C1 protein
  • ATP2C1A protein
  • AW061228 protein
  • BCPM protein
  • D930003G21Rik protein
  • HHD protein
  • hSPCA1 protein
  • pmr1 protein
  • si:dkey-11p23.6 protein
  • SPCA protein
  • Spca1 protein

Protein level used designations for ATP2C1

ATPase, Ca++ transporting, type 2C, member 1 , ATPase 2C1 , Calcium-transporting ATPase type 2C member 1 , calcium-transporting ATPase type 2C member 1-like , ATP-dependent Ca(2+) pump PMR1 , ATPase, Ca(2+)-sequestering , HUSSY-28 , calcium-transporting ATPase type 2C member 1 , secretory pathway Ca2+/Mn2+ ATPase 1 , ATPase, Ca++-sequestering , calcium-transporting ATPase 2C1 , secretory pathway Ca(2+)-ATPase 1 , secretory pathway Ca(2+)-transporting ATPase

GENE ID SPECIES
100052698 Equus caballus
100157931 Sus scrofa
460694 Pan troglodytes
100173748 Pongo abelii
100411487 Callithrix jacchus
100487845 Xenopus (Silurana) tropicalis
719281 Macaca mulatta
100030308 Monodelphis domestica
100217792 Taeniopygia guttata
100601609 Nomascus leucogenys
27032 Homo sapiens
170699 Rattus norvegicus
559574 Danio rerio
428450 Gallus gallus
477066 Canis lupus familiaris
327663 Bos taurus
235574 Mus musculus
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