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ATPase, Class I, Type 8B, Member 1 Proteins (ATP8B1)

ATP8B1 encodes a member of the P-type cation transport ATPase family, which belongs to the subfamily of aminophospholipid-transporting ATPases. Additionally we are shipping ATP8B1 Antibodies (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat ATP8B1 ATP8B1 291555  
ATP8B1 5205 O43520
ATP8B1 54670 Q148W0
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Top ATP8B1 Proteins at antibodies-online.com

Showing 5 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

ATP8B1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for ATPase, Class I, Type 8B, Member 1 (ATP8B1) Interaction Partners

Human ATPase, Class I, Type 8B, Member 1 (ATP8B1) interaction partners

  1. GGT levels in patients with ATP8B1 or ABCB11 deficiency varied with age. The peak GGT value was <70U/L in the 2nd~6th month of life, <60U/L in the 7th~12th month and <50U/L beyond one year

  2. As hypothyroidism can be another extrahepatic feature of ATP8B1 deficiency, thyroid function should be monitored in these patients.

  3. the predominant P4 ATPases in pure pancreatic beta cells and human and rat pancreatic islets were ATP8B1, ATP8B2, and ATP9A. ATP8B1 and CDC50A were highly concentrated in ISG

  4. insufficient activity of Atp8b1/FIC1 increases susceptibility to bacterial pneumonia.

  5. We systematically characterized the molecular consequences of 14 ATP8B1 mutations at exon-intron boundaries associated with ATP8B1 deficiency and found that the majority resulted in total exon skipping

  6. Data indicate that the lipid flippase (ATP8B1)-transmembrane protein 30A (CDC50A) heterodimer is essential for the apical localization of sodium-dependent bile acid transporter (SLC10A2/ASBT (show SLC10A2 Proteins)) in Caco-2 cells.

  7. We did not find an association between heterozygous ATP8B1 variants and chronic pancreatitis in our cohort of patients with hereditary and idiopathic chronic pancreatitis.

  8. Case Report: suggest contribution of ATP8B1 mutations to drug-induced liver injury from anabolic androgenic steroids marketed as dietary supplements.

  9. Case Report: missense ATP8B1 mutation in adult male with progressive familial intrahepatic cholestasis type 1.

  10. Novel splice-site mutation in ATP8B1 results in atypical progressive familial intrahepatic cholestasis type 1.

Mouse (Murine) ATPase, Class I, Type 8B, Member 1 (ATP8B1) interaction partners

  1. to become apically clustered, Cdc42 (show CDC42 Proteins) requires the interaction between its polybasic region and negatively charged membrane lipids provided by ATP8B1.

  2. The authors show that two of these transporters, ABCB11 (show ABCB11 Proteins) and ATP8B1, are functional targets of miR (show MLXIP Proteins)-33, a micro-RNA that is expressed from within an intron of SREBP-2 (show SREBF2 Proteins).

  3. Flippase ATP8B1 and the floppase ABCB4 (show ABCB4 Proteins) have complementary functions in maintaining canalicular membrane integrity.

  4. results unveil a new paradigm whereby Atp8b1 is a cardiolipin importer whose capacity to remove cardiolipin from lung fluid is exceeded during inflammation or when Atp8b1 is defective

  5. Data show that ATP8B1-deficient pups of B6 background gained less weight.

  6. Fic1 is expressed in a tissue-specific and developmentally regulated fashion at the apical membranes of epithelial cells

  7. Atp8b1 deficiency causes loss of canalicular phospholipid membrane asymmetry that in turn renders the canalicular membrane less resistant toward hydrophobic bile salts.

  8. The accumulation of bile salt (BS) in plasma of Atp8b1(G308V/G308V) mice during BS feeding is not caused by increased intestinal BS absorption.

  9. Increased biliary cholesterol excretion in Atp8b1-deficient mice is independent of Abcg5 (show ABCG5 Proteins)/8 activity.

  10. show that ATP8B1/Atp8b1 deficiency, both in patients and in Atp8b1(G308V/G308V) mutant mice, causes hearing loss, associated with progressive degeneration of cochlear hair cells

ATP8B1 Protein Profile

Protein Summary

This gene encodes a member of the P-type cation transport ATPase family, which belongs to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Mutations in this gene may result in progressive familial intrahepatic cholestasis type 1 and in benign recurrent intrahepatic cholestasis.

Gene names and symbols associated with ATP8B1

  • ATPase, aminophospholipid transporter, class I, type 8B, member 1 (Atp8b1)
  • ATPase, aminophospholipid transporter, class I, type 8B, member 1 (ATP8B1)
  • ATPase, aminophospholipid transporter, class I, type 8B, member 1 (atp8b1)
  • ATPase, class I, type 8B, member 1 (Atp8b1)
  • AI451886 protein
  • ATPIC protein
  • BRIC protein
  • FIC1 protein
  • Ic protein
  • ICP1 protein
  • MGC69272 protein
  • PFIC protein
  • PFIC1 protein

Protein level used designations for ATP8B1

ATPase, Class I, type 8B, member 1 , probable phospholipid-transporting ATPase IC , ATPase, aminophospholipid transporter, class I, type 8B, member 1 , ATPase, class I, type 8B, member 1 , ATPase, Class 1, type 8B, member 1 , E1-E2 ATPase , familial intrahepatic cholestasis type 1 , phospholipid-transporting ATPase IC , ATPase 8B1, p type , ATPase B1, class I , aminophospholipid translocase , familial intrahepatic cholestasis type I

GENE ID SPECIES
291555 Rattus norvegicus
455439 Pan troglodytes
541187 Bos taurus
594952 Xenopus (Silurana) tropicalis
733158 Xenopus laevis
100054112 Equus caballus
100126733 Papio anubis
5205 Homo sapiens
54670 Mus musculus
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