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anti-ATPase, Na+/K+ Transporting, alpha 1 Polypeptide (ATP1A1) Antibodies

The protein encoded by ATP1A1 belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Additionally we are shipping ATP1A1 Kits (24) and ATP1A1 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ATP1A1 476 P05023
ATP1A1 24211 P06685
ATP1A1 11928 Q8VDN2
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Top anti-ATP1A1 Antibodies at

Showing 10 out of 120 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated IF, WB 0.1 mg Log in to see 6 to 8 Days
Human Rabbit Un-conjugated WB Host: Rabbit  Target Name: Atp1a1  Sample Tissue: Rat Small Intestine lysates  Antibody Dilution: 1.0 µg/mL 100 μL Log in to see 2 to 3 Days
Rat Rabbit Un-conjugated WB Western blot analysis of lysate from PC-12 cell line,using Rat Atp1a1 Antibody (S23) (ABIN1882162). AP20549a was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane. 400 μL Log in to see 10 to 11 Days
Human Rabbit Un-conjugated WB Anti- ATP1A1 Picoband antibody, Western blotting All lanes: Anti ATP1A1  at 0.5ug/ml Lane 1: Rat Brain Tissue Lysate at 50ug Lane 2: A549 Whole Cell Lysate at 40ug Lane 3: HELA Whole Cell Lysate at 40ug Predicted bind size: 113KD Observed bind size: 113KD 100 μg Log in to see 4 to 6 Days
Mouse Mouse Un-conjugated WB ATP1A1  Antibody  western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the ATP1A1 antibody detected the ATP1A1 protein (arrow). 0.1 mL Log in to see 10 to 11 Days
Human Rabbit Un-conjugated IF, IHC (p), ELISA, WB Anti-ATP1A1 antibody IHC staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN959276 dilution 1:50. 50 μL Log in to see 8 to 10 Days
Cow Rabbit Un-conjugated WB Western blot analysis of ATP1A1 expression in HEK293T (A), HeLa (B) whole cell lysates. 200 μL Log in to see 9 Days
Cow Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of ATP1A1 staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a hidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of ATP1A1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. w 200 μL Log in to see 9 Days
Cow Rabbit Un-conjugated WB Western blot analysis of ATP1A1 (pS16) expression in HeLa (A), MCF7 (B), Raw264.7 (C) whole cell lysates. 200 μL Log in to see 9 Days
Human Rabbit Un-conjugated IF, IHC (p), WB Immunohistochemistry Analysis: AP20203PU-N ATP1A1 antibody staining of Paraffin-Embedded Human breast carcinoma tissue. Western blot (WB) analysis of Na+/K+ ATPase alpha-1 antibody in extracts from 293 PMA 125ng/ml 30' cells. 0.1 mg Log in to see 6 to 8 Days

ATP1A1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , , ,
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Rat (Rattus) , ,
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Mouse (Murine) , ,
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Top referenced anti-ATP1A1 Antibodies

  1. Human Monoclonal ATP1A1 Primary Antibody for IF, WB - ABIN1449189 : Clifford, Parker, Humphreys, Kertesy, Dubyak: The P2X1 receptor, an adenosine triphosphate-gated cation channel, is expressed in human platelets but not in human blood leukocytes. in Blood 1998 (PubMed)
    Show all 3 references for ABIN1449189

  2. Rat (Rattus) Polyclonal ATP1A1 Primary Antibody for WB - ABIN1882162 : Hara, Urayama, Kawakami, Nojima, Nagamune, Kojima, Ohta, Nagano, Nakao: Primary structures of two types of alpha-subunit of rat brain Na+,K+,-ATPase deduced from cDNA sequences. in Journal of biochemistry 1987 (PubMed)
    Show all 3 references for ABIN1882162

More Antibodies against ATP1A1 Interaction Partners

Human ATPase, Na+/K+ Transporting, alpha 1 Polypeptide (ATP1A1) interaction partners

  1. Our current findings demonstrate that Arctigenin is an antagonist of MR and effectively decreases the Na/K-ATPase 1 gene expression. Our work provides a hint for the drug discovery against cardiovascular disease

  2. Data suggest that targeting Na(+)/K(+) ATPase alpha-1 subunit (ATP1A1) is a approach to the treatment of hepatocellular carcinoma (HCC (show FAM126A Antibodies)).

  3. Mutations in ATP1A1 gene is associated with aldosterone-producing adenomas.

  4. Gal-3 (show LGALS3 Antibodies) interacts with ATP1A1 and induces the phosphorylation of MDR1 (show TBC1D9 Antibodies), mediating multidrug resistance.

  5. protein kinase A and C activation can increase Na,K-ATPase activity in human muscle but not via P2Y (show P2RY1 Antibodies) receptor stimulation.

  6. Mutations of the ATP1A1 depolarize adrenocortical cells, disturb the K+ sensitivity, and lower intracellular pH but do not induce an overt increase of intracellular Ca2 (show CA2 Antibodies)+.

  7. Different mutations (KCNJ5 (show KCNJ5 Antibodies), ATP1A1, ATP2B3 (show ATP2B3 Antibodies), and CACNA1D (show CACNA1D Antibodies)) are found in different aldosterone-producing nodules from the same adrenal, suggesting that somatic mutations are independent events triggered by mechanisms that remain to be identified.

  8. Data shows that a functional 12T-insertion polymorphism in the ATP1A1 promoter confers decreased susceptibility to hypertension in a male Sardinian population supporting ATP1A1 as a hypertension susceptibility gene in this population.

  9. Data show that the intracellular M4M5 loop of human alpha1 subunit of Na+,K+-ATPase (ATP1a1) interacts directly with rat rab (show HRB Antibodies) GTP-binding protein Rab27a (show RAB27A Antibodies).

  10. Ebola VP24 protein plays a critical role in the evasion of the host immune response by interacting with human ATP1a1 protein.

Pig (Porcine) ATPase, Na+/K+ Transporting, alpha 1 Polypeptide (ATP1A1) interaction partners

  1. Uroguanylin (show GUCA2B Antibodies) modulates (Na++K+)ATPase in a proximal tubule cells via cGMP/protein kinase (show CDK7 Antibodies) G, cAMP/protein kinase A, and mTOR (show FRAP1 Antibodies) pathways.

  2. Data indicate that magnesium fluoride, magnesium fluoride and Na,K-ATPase form a very stable complex in the E2 conformation.

  3. Data indicate that Rb(+) can be occluded through Na(+)/K(+)-ATPase cycling mode that takes place in the absence of Na(+) ions.

  4. Expression of mutant alpha1 Na/K-ATPase defective in conformational transition attenuates Src (show SRC Antibodies)-mediated signal transduction

  5. re-arrangements of the Na+,K+-ATPase stabilized by cardiotonic steroids may affect protein-protein interactions within the intracellular signal transduction networks

  6. Data indicate that the transmembrane domain of the Na+/K+ -ATPase in the E1 state is less exposed to the lipids than in E2.

  7. The plasma membrane Na/K-ATPase-caveolin-1 (show CAV1 Antibodies) interaction may represent an important sensing mechanism by which the cells regulate the sterol regulatory element-binding protein (show CNBP Antibodies) pathway.

  8. Investigations of K(+)-occlusion by the phosphoenzyme of Na(+),K(+)-ATPase from shark rectal gland and pig kidney by stopped-flow fluorimetry reveal major differences in the kinetics of the two enzymes.

  9. The results indicate that PKC (show FYN Antibodies) could be the final target and an integrator molecule of different signaling pathways triggered by angiotensin II (Ang II), which could explain the sustained activation of Na(+)-ATPase (show DNAH8 Antibodies) by Ang II (show AGT Antibodies).

  10. Na,K-ATPase is (show ATP11A Antibodies) a new target of TGF-beta(1 (show TGFB1 Antibodies))-mediated Epithelial-to-mesenchymal transition in renal epithelial cells, a model system used in studies of both cancer progression and fibrosis.

Cow (Bovine) ATPase, Na+/K+ Transporting, alpha 1 Polypeptide (ATP1A1) interaction partners

  1. Suggest ATP1A1 has a central role in the osmoregulatory response of nucleus pulposus cells.

  2. The ATP1A1 gene polymorphism has potential as a marker for mastitis resistance in dairy cattle.

  3. The polymorphisms within the coding region of bovine ATP1A1 gene, were analyzed.

  4. ATP1A1 gene polymorphism has a role in heat tolerance traits in dairy cattle

Xenopus laevis ATPase, Na+/K+ Transporting, alpha 1 Polypeptide (ATP1A1) interaction partners

  1. The C-terminal contacts of Xenopus Na,K-ATPase alpha-1 provide important stabilization of the occluded E1P(Na3) pump conformation, regardless of the route of Na ion entry into the binding pocket.

Rabbit ATPase, Na+/K+ Transporting, alpha 1 Polypeptide (ATP1A1) interaction partners

  1. Altered localization of Na-K-ATPase as a result of transcriptional down-regulation of ankyrin-G (show ANK3 Antibodies) mediates the down-regulation of Na-K-ATPase activity during chronic intestinal inflammation.

  2. Pb(2+) ions are able to confine the Na(+),K(+)-ATPase into a phosphorylated E(2) state.

Mouse (Murine) ATPase, Na+/K+ Transporting, alpha 1 Polypeptide (ATP1A1) interaction partners

  1. Study identified the Na+/K+-ATPase alpha 1 and 3 subunits as receptors for the extracellular fragment of GPNMB that mediates activation of cellular signaling pathways and subsequent neuroprotective effects.

  2. effects of endogenous acetylcholine on alveolar fluid clearance are likely mediated by Na,K-ATPase function through activation of muscarinic acetylcholine receptors on alveolar epithelia

  3. Oxidized LDL-bound CD36 (show CD36 Antibodies) recruits an Na/K-ATPase-Lyn (show LYN Antibodies) complex in macrophages that promotes atherosclerosis.

  4. TGFbeta1 (show TGFB1 Antibodies) is a powerful regulator of megakaryocytic Na+/K+ ATPase activity.

  5. Inhibition of the Na+/K+-ATPase pathway in astrocytes leads to rearrangement of cytoskeleton.

  6. Reduction of Na/K-ATPase affects cardiac remodeling and increases c-kit (show KIT Antibodies) cell abundance in partial nephrectomized mice.

  7. Enhanced Na+ entry did not alter Na,K-ATPase a1 mRNA level in tranfected mCDD cells. Post-transcriptional control of Na,K-ATPase abundance is effected by lysosomal degradation.

  8. This coupling of astrocytic A2ARs to the regulation of glutamate (show GRIN1 Antibodies) transport through modulation of NKA (show TAC1 Antibodies)-alpha2 activity provides a novel mechanism linking neuronal activity to ion homeostasis controlling glutamatergic activity.

  9. Concurrent impairment of Na(+)+K(+)-ATPase function in multi-organ may serve as one of the molecular pathways participating in and contributing to the mechanism of type-1 diabetes-induced complications in NOD mice.

  10. Activation of Na,K-ATPase protects against oxidative damage in an animal model of pentylenetetrazol-induced seizures.

Guinea Pig ATPase, Na+/K+ Transporting, alpha 1 Polypeptide (ATP1A1) interaction partners

  1. Data identify the K+-independent, ouabain-insensitive Na+-ATPase (show DNAH8 Antibodies) as a unique P-type ATPase (show ATP7A Antibodies).

ATP1A1 Antigen Profile

Protein Summary

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with ATP1A1

  • ATPase, Na+/K+ transporting, alpha 1 polypeptide (ATP1A1) antibody
  • ATPase, Na+/K+ transporting, alpha 1 polypeptide (Atp1a1) antibody
  • ATPase, Na+/K+ transporting, alpha 1 polypeptide (atp1a1-a) antibody
  • atp1a1 antibody
  • atp1a1a.1 antibody
  • Atpa-1 antibody
  • BC010319 antibody
  • K-ATPase antibody
  • Na+K+ATPase antibody
  • Nkaa1b antibody

Protein level used designations for ATP1A1

Na/K ATPase , (Na+ + K+)-ATPase , Na(+)/K(+) ATPase alpha-1 subunit , sodium pump subunit alpha-1 , sodium/potassium-transporting ATPase subunit alpha-1 , Na+, K+ ATPase alpha subunit , Na+/K+ ATPase 1 , Na, K-ATPase, alpha-A catalytic polypeptide , Na,K-ATPase alpha-1 subunit , Na,K-ATPase catalytic subunit alpha-A protein , sodium pump 1 , sodium-potassium ATPase catalytic subunit alpha-1 , sodium-potassium-ATPase, alpha 1 polypeptide , ATPase, Na+K+ transporting, alpha 1 , (Na+, K+)-ATPase alpha-subunit , Na+/K+ transporting alpha 1 polypeptide , sodium/potassium-transporting ATPase alpha-1 chain , Na+-K+-ATPase alpha 1 subunit , Na+/K+ ATPase , Na+K+ ATPase , Na+/K+ -ATPase alpha 1 subunit , Na/K ATPase alpha 1 subunit , sodium/potassium-ATPase alpha-subunit 1 , alpha1 subunit of equine Na/K ATPase , horse alpha-1 subunit of Na,K-ATPase

100303690 Meleagris gallopavo
396530 Gallus gallus
476 Homo sapiens
403992 Canis lupus familiaris
24211 Rattus norvegicus
397481 Sus scrofa
282144 Bos taurus
443381 Ovis aries
399285 Xenopus laevis
100302415 Oryctolagus cuniculus
11928 Mus musculus
100192382 Cavia porcellus
100034139 Equus caballus
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