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ATPIF1 encodes a mitochondrial ATPase inhibitor. Additionally we are shipping ATPase Inhibitory Factor 1 Antibodies (67) and many more products for this protein.
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CF6 (show ATP5J Proteins)-induced increase in apoptotic cells was blocked by immature or mature IF1, being accompanied by protein kinase B (PKB (show AKT1 Proteins)) phosphorylation. IF1 antagonizes the pro-apoptotic action of CF6 (show ATP5J Proteins) by relief of intracellular acidification and resultant phosphorylation of PKB (show AKT1 Proteins).
The potential role of mitochondrial ATPIF1 in coronary heart disease was reviewed.
this study shows that abnormal expression of ATPase inhibitor, mitochondrial isoform 1 precursor(IF1) may relate to the hyperfunction of immune responses and excessive apoptosis of severe aplastic anemia CD34 (show CD34 Proteins)(+) cells
These data suggest that in mammalian neurons mitochondria adapt to respiratory stress by upregulating IF1, which exerts a protective role by coordinating pro-survival cell mitophagy and bioenergetics resilience
Data indicate that oxidative phosphorylation (OXPHOS) is inhibited in the liver of mice expressing human ATPase inhibitory factor 1 (hIF1).
Upon IF1 interaction with the ATP synthase both the synthetic and hydrolytic activities of the engine of oxidative phosphorylation are inhibited. (Review)
PKA phosphorylates the ATPase inhibitory factor 1 and inactivates its capacity to bind and inhibit the mitochondrial H(+)-ATP synthase.
IF1 was overexpressed in bladder cancer; concluded that IF1 may be a novel therapeutic target for bladder cancer
These results indicate that IF1 may serve as a prognostic marker and promotes tumor growth and metastasis in gastric cancer.
interaction of IF1 with the complex either directly, by increasing the catalytic activity of the enzyme, or indirectly, by improving the structure of mitochondrial cristae, can increase the oxidative phosphorylation rate in osteosarcoma cells
The intrinsically disordered inhibitory region of IF1 interacts first with the alphaEbetaE-catalytic interface, the most open of the three catalytic interfaces, where the available interactions with the enzyme allow it to form an alpha-helix from residues 31-49.
The N-terminal region of IF(1) destabilizes the interaction of the inhibitor with F(1)-ATPase and may assist in removing the inhibitor from its binding site when F(1)F(o)-ATPase is (show ATP11A Proteins) making ATP
in addition to His49, Glu26 participates in pH sensing in bovine IF(1), and the mechanism of pH sensing mediated by Glu26 is different from the dimer-tetramer model proposed previously
induces VEGF expression and promotes xenograft tumor-induced angiogenesis
IF1 is not an essential protein for mice despite its ubiquitous presence in eukaryotes.
methionine deprivation results in an antioxidant response that includes an increase in the levels of HSPA1A (show HSPA1A Proteins) and DNAJB1 (show DNAJB1 Proteins) mRNA
the identification of mitochondrial Atpif1 as a regulator of haem synthesis advances our understanding of the mechanisms regulating mitochondrial haem homeostasis and red blood cell development
Findings support that the mitochondrial content of IF1 controls the activity of oxidative phosphorylation mediating the shift of cancer cells to an enhanced aerobic glycolysis.
The study reveals that IEX-1 (show IER3 Proteins) targets the mitochondrial F1Fo-ATPase Inhibitor (IF1) for degradation, resulting in acceleration of ATP hydrolysis, concomitant with reduction in ROS (show ROS1 Proteins) production.
This gene encodes a mitochondrial ATPase inhibitor. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified.
ATPase inhibitory factor 1
, ATPase inhibitor, mitochondrial
, Inhibitor of F(1)F(o)-ATPase
, ATP synthase inhibitor protein
, ATPase inhibitor protein
, inhibitor of F(1)F(o)-ATPase
, mitochondrial ATPIF1
, ATPase inhibitor (rat mitochondrial IF1 protein)
, ATPase inhibitor A, mitochondrial
, inhibitor of F(1)F(o)-ATPase A
, protein pinotage
, ATP synthase CF0 A subunit