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ATX1 Antioxidant Protein 1 Homolog (Yeast) Proteins (ATOX1)

ATOX1 encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. Additionally we are shipping ATOX1 Antibodies (27) and ATOX1 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ATOX1 475 O00244
ATOX1 84355 Q9WUC4
ATOX1 11927 O08997
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Top ATOX1 Proteins at antibodies-online.com

Showing 10 out of 16 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$286.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 16 Days
$437.80
Details
Yeast Sheep His tag   1 mg Log in to see 56 to 66 Days
$2,075.33
Details
Yeast Dog His tag   1 mg Log in to see 56 to 66 Days
$2,075.33
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,075.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,075.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$322.14
Details

ATOX1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus)

Mouse (Murine)

Top referenced ATOX1 Proteins

  1. Human ATOX1 Protein expressed in Escherichia coli (E. coli) - ABIN666917 : Hamza, Schaefer, Klomp, Gitlin: Interaction of the copper chaperone HAH1 with the Wilson disease protein is essential for copper homeostasis. in Proceedings of the National Academy of Sciences of the United States of America 1999 (PubMed)
    Show all 2 references for ABIN666917

More Proteins for ATX1 Antioxidant Protein 1 Homolog (Yeast) (ATOX1) Interaction Partners

Fruit Fly (Drosophila melanogaster) ATX1 Antioxidant Protein 1 Homolog (Yeast) (ATOX1) interaction partners

  1. results clearly reveal a distorted copper homeostasis in Atox1-deficient Drosophila

Human ATX1 Antioxidant Protein 1 Homolog (Yeast) (ATOX1) interaction partners

  1. In addition to Atox1, the human cytoplasm also contains Cu chaperones for loading of superoxide dismutase 1 (show SOD1 Proteins) (i.e. CCS (show CCS Proteins)) and cytochrome c (show CYCS Proteins) oxidase in mitochondria (i.e. Cox17 (show COX17 Proteins)). [review]

  2. results suggest the possibility of a therapy with copper-chelating or ionophore drugs in subtypes of tumors showing specific alterations in ATOX1 expression

  3. C-Terminus of Human Copper Importer Ctr1 (show SLC31A1 Proteins) Acts as a Binding Site and Transfers Copper to Atox1

  4. Cu chaperone function of Atox1 mediated through Cu transporter ATP7A (show ATP7A Proteins) is required for VEGF (show VEGFA Proteins)-induced angiogenesis via activation of Cu enzyme lysyl oxidase (show LOX Proteins).

  5. Upon neuronal differentiation, transitions in redox states upregulates expression of ATOX1 and its partner ATP7A (show ATP7A Proteins), producing higher flux of copper through the secretory pathway.

  6. To identify new interactions partners of Atox1, a yeast two-hybrid screen with a large human placenta library of cDNA fragments using Atox1 as bait, was performed.

  7. Studied the localization of Atox1 in HeLa cells using fluorescence imaging in combination with in vitro binding experiments to fluorescently labeled DNA duplexes harboring the proposed promotor sequence.

  8. Human cytoplasmic copper chaperones Atox1 and CCS (show CCS Proteins) exchange copper ions in vitro

  9. Cisplatin is one of the most used anticancer drugs. Its cellular influx and delivery to target DNA may involve the copper chaperone Atox1 protein.

  10. The data collected here shows that the Atox1 keeps its dimer nature also in the presence of the CTR1 (show SLC31A1 Proteins) c-terminal domain; however, two geometrical states are assumed by the Atox1.

Mouse (Murine) ATX1 Antioxidant Protein 1 Homolog (Yeast) (ATOX1) interaction partners

  1. Cu chaperone function of Atox1 mediated through Cu transporter ATP7A (show ATP7A Proteins) is required for VEGF (show VEGFA Proteins)-induced angiogenesis via activation of Cu enzyme lysyl oxidase (show LOX Proteins).

  2. Atox1 is involved in neointimal formation after vascular injury through promoting vascular smooth muscle cell migration and inflammatory cell recruitment in injured vessels

  3. Atox1 functions to prevent Ang II (show AGT Proteins)-induced endothelial dysfunction and hypercontraction in resistant vessels, as well as hypertension.

  4. the importance of Atox1, not only as a metallochaperone for delivering Cu to cuproenzymes, but also as a key player in maintaining the proper distribution and organization of Cu at the cellular level

  5. ATOX1 is a cytoplasmic copper chaperone that interacts with the copper-binding domain of the membrane copper transporters ATP7A (show ATP7A Proteins) and ATP7B (show ATP7B Proteins)

  6. Atox1 has a role in establishing the threshold for copper-dependent movement of the copper-transporting ATPases within the secretory compartment

  7. Atox1 functions not only as a copper chaperone for SOD3 (show SOD3 Proteins) but also as a positive regulator for SOD3 (show SOD3 Proteins) transcription and may have an important role in modulating oxidative stress in the cardiovascular system.

  8. Atox1 functions as a novel transcription factor that, when activated by copper, undergoes nuclear translocation, DNA binding, and transactivation, thereby contributing to cell proliferation.

  9. both the copper chaperone and the transcription factor functions are required for the activity of antioxidant enzyme, superoxide dismutase (SOD3 (show SOD3 Proteins))

  10. Atox1 is required for the polyubiquitination of Ctr1 (show SLC31A1 Proteins) and the Ctr1 (show SLC31A1 Proteins)-mediated uptake of CDDP.

ATOX1 Protein Profile

Protein Summary

This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome.

Gene names and symbols associated with ATOX1

  • ATX1 antioxidant protein 1 homolog (yeast) (ATOX1)
  • CG32446 gene product from transcript CG32446-RA (Atox1)
  • ATX1 antioxidant protein 1 homolog (atox1)
  • copper transport protein (atox1)
  • Copper transport protein ATOX1 (atox1)
  • ATX1 antioxidant protein 1 homolog (LOC100335457)
  • antioxidant 1 copper chaperone (ATOX1)
  • antioxidant 1 copper chaperone (Atox1)
  • ATX1 (antioxidant protein 1) homolog 1 (yeast) (Atox1)
  • AI256639 protein
  • ATOX1 protein
  • Atx1 protein
  • CG12562 protein
  • CG32446 protein
  • DDBDRAFT_0185901 protein
  • DDBDRAFT_0266724 protein
  • DDB_0185901 protein
  • DDB_0266724 protein
  • DmAtox1 protein
  • Dmel\\CG32446 protein
  • HAH1 protein
  • SAH protein

Protein level used designations for ATOX1

ATX1 antioxidant protein 1 homolog (yeast) , copper transport protein ATOX1 , antioxidant protein 1 homolog , Atox1-PA , Atox1-PB , CG32446-PA , CG32446-PB , ATX1 antioxidant protein 1 homolog , Copper transport protein ATOX1 , metal transport protein ATX1 , ATX1 (antioxidant protein 1) homolog 1 , ATX1 homolog protein Rah1 , copper chaperone , copper chaperone SAH

GENE ID SPECIES
743743 Pan troglodytes
770231 Gallus gallus
100312962 Sus scrofa
326216 Drosophila melanogaster
734100 Xenopus (Silurana) tropicalis
8624483 Dictyostelium discoideum AX4
100301872 Oncorhynchus mykiss
100335457 Bos taurus
475 Homo sapiens
84355 Rattus norvegicus
11927 Mus musculus
613998 Bos taurus
403713 Canis lupus familiaris
443451 Ovis aries
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