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Abhydrolase Domain Containing 12 Proteins (ABHD12)

ABHD12 encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. Additionally we are shipping ABHD12 Antibodies (54) and ABHD12 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ABHD12 76192 Q99LR1
Rat ABHD12 ABHD12 499913 Q6AYT7
ABHD12 26090 Q8N2K0
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Top ABHD12 Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$2,794.00
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$2,806.83
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

ABHD12 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human , , ,
, ,

More Proteins for Abhydrolase Domain Containing 12 (ABHD12) Interaction Partners

Mouse (Murine) Abhydrolase Domain Containing 12 (ABHD12) interaction partners

  1. In mouse macrophages, disruption of ABHD12 and ABHD16A (show ABHD16A Proteins) respectively increases and decreases both lysophosphatidylserines and lipopolysaccharide-induced cytokine production.

  2. FAAH (show FAAH Proteins) but not monoacyl glycerol lipase (show LIPG Proteins) exerts important protective actions against 2-arachidonoyl glycerol-induced cellular damage.

  3. provide a molecular model for PHARC, where disruption of ABHD12 causes deregulated LPS (show TLR4 Proteins) metabolism and the accumulation of proinflammatory lipids that promote microglial and neurobehavioral abnormalities

  4. Mutations in the ABHD12 gene cause polyneuropathy, hearing loss, ataxia (show USP14 Proteins), retinitis pigmentosa, and cataract disease.

  5. Data reveal that 85% of brain 2 (show POU3F2 Proteins)-arachidonoylglycerol hydrolase (show ABHD6 Proteins) activity can be ascribed to monoacylglycerol lipase(MAGL (show MGLL Proteins)), and the remaining 15% is catalyzed by ABHD6 (show ABHD6 Proteins) and ABHD12.

Human Abhydrolase Domain Containing 12 (ABHD12) interaction partners

  1. ABHD12 mutation in 2 PHARC (Polyneuropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, And Cataract)patients who suffered from deaf-blindness and dysfunctional central and peripheral nervous systems.

  2. Null mutations in the ABHD12 gene lead to PHARC syndrome, a neurodegenerative disease including polyneuropathy, hearing loss, cerebellar ataxia (show USP14 Proteins), RP, and early-onset cataract. Our study allowed us to report 5 new mutations in ABHD12.

  3. This is the first report of compound heterozygosity in PHARC and the first study to describe how a mutation might affect ABHD12 expression and function.

  4. ABHD12 mutations are not a frequent cause of ataxia (show USP14 Proteins) at least in Southern Italy

  5. After the identification of the ABHD12 mutation in this family, one patient underwent neurological examination which revealed ataxia (show USP14 Proteins), but no polyneuropathy

  6. Data show that the three hydrolases are genuine MAG (show MAG Proteins) lipases; medium-chain saturated MAGs were the best substrates for hABHD6 and hMAGL, whereas hABHD12 preferred the 1 (3)- and 2-isomers of arachidonoylglycerol.

  7. Mutations in the ABHD12 gene cause polyneuropathy, hearing loss, ataxia (show USP14 Proteins), retinitis pigmentosa, and cataract disease.

ABHD12 Protein Profile

Protein Summary

This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Gene names and symbols associated with ABHD12

  • abhydrolase domain containing 12 (ABHD12)
  • abhydrolase domain containing 12 (CC1G_02966)
  • abhydrolase domain containing 12 (PTRG_02160)
  • abhydrolase domain containing 12 (abhd12)
  • abhydrolase domain containing 12 (LOC100342158)
  • abhydrolase domain containing 12 (Abhd12)
  • 1500011G07Rik protein
  • 6330583M11Rik protein
  • ABHD12 protein
  • ABHD12A protein
  • AI431047 protein
  • AW547313 protein
  • BEM46L2 protein
  • C20orf22 protein
  • dJ965G21.2 protein
  • PHARC protein

Protein level used designations for ABHD12

abhydrolase domain containing 12 , monoacylglycerol lipase ABHD12-like , 2-arachidonoylglycerol hydrolase , abhydrolase domain-containing protein 12 , monoacylglycerol lipase ABHD12

GENE ID SPECIES
477004 Canis lupus familiaris
744997 Pan troglodytes
6012413 Coprinopsis cinerea okayama7130
6339600 Pyrenophora tritici-repentis Pt-1C-BFP
100380988 Xenopus laevis
100449601 Pongo abelii
100466451 Ailuropoda melanoleuca
100342158 Oryctolagus cuniculus
76192 Mus musculus
499913 Rattus norvegicus
26090 Homo sapiens
768242 Bos taurus
421249 Gallus gallus
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