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Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Additionally we are shipping ABHD4 Kits (20) and ABHD4 Proteins (5) and many more products for this protein.
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Mouse (Murine) Polyclonal ABHD4 Primary Antibody for IHC (p), WB - ABIN657593
Simon, Cravatt: Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathway. in The Journal of biological chemistry 2006
ABHD4 is a novel genetic regulator of anoikis sensitivity.
Lysophospholipase/phospholipase B (EC 22.214.171.124) specific for N-acyl phosphatidylethanolamine (NAPE) suggesting a role in the biosynthesis of N-acyl ethanolamines including the endocannabinoid anandamide.
These findings, taken together, designate ABHD4 as a principal regulator of N-acyl phospholipid metabolism in the mammalian nervous system.
Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine (By similarity).
abhydrolase domain containing 4
, abhydrolase domain containing 5
, abhydrolase domain-containing protein 4
, alpha/beta-hydrolase 4
, lyso-N-acylphosphatidylethanolamine lipase