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The protein encoded by ABHD5 belongs to a large family of proteins defined by an alpha/beta hydrolase fold, and contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. Additionally we are shipping ABHD5 Antibodies (77) and ABHD5 Kits (1) and many more products for this protein.
Showing 7 out of 9 products:
Case Report: novel ABHD5 mutation, c.838C > T (p.Arg280*), in trans with p.Arg234* in a Chinese patient with very mild Dorfman-Chanarin syndrome.
Authors show that rat ATGL (show PNPLA2 Proteins), coactivated by rat CGI-58, efficiently hydrolyzes triglycerides and retinyl ester.
novel ABHD5 truncating variant in a twenty nine month old female child, who presented with icthyosiform erythroderma.
simultaneous tryptophan alanine permutations in both arms abolish localization and activity of CGI-58 as opposed to tryptophan substitutions that occur in only one arm.
this study presents clinical and molecular data of four affected relatives with Chanarin-Dorfman syndrome homozygous for a N209X mutation in ABHD5, and provides a short review by comparing patients with N209X homozygous mutations to patients with other ABHD5 mutations.
PLIN5 (show PLIN5 Proteins) was significantly colocated with ATGL (show PNPLA2 Proteins), mitochondria and CGI-58, indicating a close association between the key lipolytic effectors in resting skeletal muscle.
-mediated phosphorylation of CGI-58 is required for dispersion of CGI-58 from perilipin (show PLIN1 Proteins) 1A-coated lipid droplets
Abhd5 expression falls substantially and correlates negatively with malignant features in human colorectal cancer.
Findings indicate a molecular mechanisms by which lysophosphatidic acid acyltransferase (show MBOAT2 Proteins) CGI-58 regulates lipid homeostasis.
ABHD5, PGRMC1 (show PGRMC1 Proteins) and SQS (show FDFT1 Proteins) are novel markers for sebaceous carcinoma and can reliably distinguish sebaceous neoplasms from non-sebaceous tumors, specifically BCC with clear cell features.
These results demonstrate that macrophage CGI-58 enhances PPAR-gamma (show PPARG Proteins) signaling and thus suppresses inflammatory responsiveness and mitochondrial dysfunction in macrophages.
Here, we identify synthetic ligands that release ABHD5 from PLIN1 (show PLIN1 Proteins) or PLIN5 (show PLIN5 Proteins) without PKA activation and rapidly activate adipocyte and muscle lipolysis.
we identify adipocyte-type fatty acid-binding protein (A-Fabp (show FABP4 Proteins)) and other members of the fatty acid-binding protein (Fabp (show FABP Proteins)) family as interaction partners of Cgi-58.
Data (including data from studies in atherosclerotic knockout mice) suggest CGI58-deficient macrophages store-up triglyceride-rich droplets and have reduced phagocytic capacity, comparable to Atgl- (adipose triglyceride lipase (show PNPLA2 Proteins)-)deficient macrophages.
Muscle CGI-58 deficiency causes cardiac dysfunction and fat deposition in oxidative muscles but induces a series of favorable metabolic changes in mice fed a high-fat diet.
intestinal CGI-58 is required for efficient postprandial lipoprotein-TG secretion and for maintaining hepatic and plasma lipid homeostasis.
CGI-58 transgenic/ApoE (show APOE Proteins)-/- mice exhibited an anti-atherosclerosis phenotype compared with wild type (WT) controls (CGI-58 WT/ApoE (show APOE Proteins)-/-), illustrated by less plaque area in aortic roots.
The anti-lipolytic activity of the HCV core protein alters ATGL (show PNPLA2 Proteins) binding to CGI-58 and enhances the association of both proteins with lipid droplets.
These data thus identified a vicious cycle (IL-1beta (show IL1B Proteins)-SOCS3 (show SOCS3 Proteins)-FOXO1 (show FOXO1 Proteins)-IL-1beta (show IL1B Proteins)) that amplifies IL-1beta (show IL1B Proteins) secretion and is initiated by CGI-58 deficiency-induced activation of the NLRP3 (show NLRP3 Proteins) inflammasome in macrophages.
These findings suggest that CGI-58 may be a new target for enhancing the quality of pork products as well as offering the potential of CGI-58 for human obesity treatment.
The protein encoded by this gene belongs to a large family of proteins defined by an alpha/beta hydrolase fold, and contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. It differs from other members of this subfamily in that its putative catalytic triad contains an asparagine instead of the serine residue. Mutations in this gene have been associated with Chanarin-Dorfman syndrome, a triglyceride storage disease with impaired long-chain fatty acid oxidation.
abhydrolase domain containing 5
, CGI58 protein
, 1-acylglycerol-3-phosphate O-acyltransferase ABHD5
, abhydrolase domain-containing protein 5
, lipid droplet-binding protein CGI-58
, alpha/beta hydrolase domain-containing 5
, lipid droplet binding protein
, Abhydrolase domain-containing protein 5