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anti-Absent in Melanoma 2 (AIM2) Antibodies

AIM2 is a member of the IFI20X /IFI16 family. Additionally we are shipping AIM2 Kits (11) and AIM2 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
AIM2 9447 O14862
AIM2 383619 Q91VJ1
AIM2 304987  
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Top anti-AIM2 Antibodies at antibodies-online.com

Showing 10 out of 183 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-AIM2 Antibody Titration: 0.2-1 ug/mlPositive Control: Human Lung 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated EIA, IHC (p), WB AP22454PU-N AIM2 antibody staining of paraffin embedded Human Spleen at 3.8 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. AP22454PU-N AIM2 antibody staining of IFNbeta-treated WI-38 lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated EIA, FACS, WB AIM2 Antibody (N-term) flow cytometric analysis of MCF-7 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Western blot analysis of AIM2 Antibody (N-term) in MCF-7, HL-60, K562, Hela cell line lysates (35 µg/lane). AIM2 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HuvEc cells, using AIM2 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated FACS, IF, WB Western blot analysis of AIM2 Antibody (N-term) (ABIN653833) in MCF-7, HL-60, K562, Hela cell line lysates (35 µg/lane). AIM2 (arrow) was detected using the purified polyclonal antibody. AIM2 Antibody (N-term) (ABIN653833) flow cytometric analysis of MCF-7 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated WB AIM2 Antibody (ABIN1882191) western blot analysis in NCI-H292 cell line lysates (35 µg/lane). This demonstrates the AIM2 antibody detected the AIM2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated WB LCK Antibody (ABIN1882206) western blot analysis in HL-60,Jurkat,NCI-H292 cell line lysates (35 µg/lane). This demonstrates the LCK antibody detected the LCK protein (arrow). 100 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated ICC, WB   100 μg Log in to see 5 to 8 Days
$393.75
Details
Human Rabbit Un-conjugated IP, WB Immunoprecipitation of AIM2 transfected lysate using anti-AIM2 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with AIM2 purified MaxPab mouse polyclonal antibody (B01P) . Western Blot analysis of AIM2 expression in transfected 293T cell line by AIM2 MaxPab polyclonal antibody.Lane 1: AIM2 transfected lysate(39.00 KDa).Lane 2: Non-transfected lysate. 100 μL Log in to see 9 Days
$418.57
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- AIM2 Picoband antibody, IHC(P) IHC(P): Human Lung Cancer Tissue Observed bind size: 45KD 100 μg Log in to see 4 to 6 Days
$240.00
Details

AIM2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-AIM2 Antibodies

  1. Human Polyclonal AIM2 Primary Antibody for EIA, FACS - ABIN950314 : Patsos, Germann, Gebert, Dihlmann: Restoration of absent in melanoma 2 (AIM2) induces G2/M cell cycle arrest and promotes invasion of colorectal cancer cells. in International journal of cancer. Journal international du cancer 2010 (PubMed)
    Show all 6 references for ABIN950314

  2. Human Monoclonal AIM2 Primary Antibody for WB - ABIN1882206 : Chen, Ou-Yang, Hung, Liu, Wang, Wang, Hou, Hortobagyi, Hung: AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model. in Molecular cancer therapeutics 2006 (PubMed)
    Show all 5 references for ABIN1882206

  3. Human Monoclonal AIM2 Primary Antibody for WB - ABIN1882191 : DeYoung, Ray, Su, Anzick, Johnstone, Trapani, Meltzer, Trent: Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma. in Oncogene 1997 (PubMed)
    Show all 5 references for ABIN1882191

  4. Human Polyclonal AIM2 Primary Antibody for FACS, IF - ABIN653833 : Hornung, Ablasser, Charrel-Dennis, Bauernfeind, Horvath, Caffrey, Latz, Fitzgerald: AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. in Nature 2009 (PubMed)
    Show all 4 references for ABIN653833

  5. Human Monoclonal AIM2 Primary Antibody for ICC, WB - ABIN1169341 : Cresswell, Clarke, Jackson, Darcy, Trapani, Johnstone: Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2. in Biochemical and biophysical research communications 2004 (PubMed)
    Show all 3 references for ABIN1169341

  6. Human Polyclonal AIM2 Primary Antibody for ELISA, WB - ABIN1534265 : Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: The DNA sequence and biological annotation of human chromosome 1. ... in Nature 2006 (PubMed)
    Show all 2 references for ABIN1534265

  7. Human Polyclonal AIM2 Primary Antibody for IP, WB - ABIN948806 : Adamczak, de Rivero Vaccari, Dale, Brand, Nonner, Bullock, Dahl, Dietrich, Keane: Pyroptotic neuronal cell death mediated by the AIM2 inflammasome. in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2014 (PubMed)

  8. Human Polyclonal AIM2 Primary Antibody for EIA, IHC (p) - ABIN569662 : Fernandes-Alnemri, Yu, Datta, Wu, Alnemri: AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. in Nature 2009 (PubMed)

  9. Human Polyclonal AIM2 Primary Antibody for WB - ABIN2784209 : Woerner, Kloor, Schwitalle, Youmans, Doeberitz, Gebert, Dihlmann: The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers. in Genes, chromosomes & cancer 2007 (PubMed)

More Antibodies against AIM2 Interaction Partners

Human Absent in Melanoma 2 (AIM2) interaction partners

  1. The extent of NLRC3 (show NLRC3 Antibodies) and AIM2 gene reduction was correlated with cancer progression.

  2. Molecular docking analysis reveals that the conformation switching may be important for the autoinhibition of the AIM2 protein.

  3. A significant upregulation of the PYHIN inflammasomes AIM2 and IFI16 (show IFI16 Antibodies) in active inflammatory bowel disease versus controls was found.

  4. Lung tumor-associated plasmacytoid dendritic cells (pDCs) are responsive to the activation of AIM2 that promotes calcium efflux and reactive oxygen species from mitochondria, leading to calpain activation and high levels of IL-1alpha.

  5. analysis of a subset of inflammasome receptors including NLRP3 (show NLRP3 Antibodies), NLRC4 (show NLRC4 Antibodies) and AIM2 that triggers formation of the micrometer-sized spherical supramolecular complex called the ASC (show PYCARD Antibodies) speck

  6. pyrin (show MEFV Antibodies) domain drives both filament formation and dsDNA binding

  7. activation of the AIM2 inflammasome did not require a priming signal in ascitic fluid-derived macrophages, demonstrating the preactivated state of the inflammasome in these cells.

  8. These results suggest that AIM2 expressed in human dental pulp plays an important role in the immune defense by activating the inflammasome signaling pathway.

  9. The comparison shows mouse AIM2 PYD domain adopts a unique alpha2-alpha3 helix conformation distinct from its human homologues, but similar to the pyrin (show MEFV Antibodies) domain of human NLRP10/PYNOD (show NLRP10 Antibodies), which belongs to another family.

  10. Increased expression and activation of absent in melanoma 2 inflammasome components in lymphocytic infiltrates of abdominal aortic aneurysms

Mouse (Murine) Absent in Melanoma 2 (AIM2) interaction partners

  1. Molecular docking analysis reveals that the conformation switching may be important for the autoinhibition of the AIM2 protein.

  2. in vitro activation of the AIM2 inflammasome in murine macrophages and dendritic cells leads to reduced activation of the STING pathway, in part through promoting caspase-1 (show CASP1 Antibodies)-dependent cell death.

  3. A tissue-specific role for the AIM2 inflammasome as a sensor for endogenous DNA species in the course of a ligand-dependent autoinflammatory condition.

  4. AIM2 inflammsome is functionally redundant in the inflammasomemediated caspase-1 (show CASP1 Antibodies) activation and IL-1beta (show IL1B Antibodies) production during P. aeruginosa infection.

  5. Mice lacking both AIM2 and NLRP3 (show NLRP3 Antibodies) fail to confine Aspergillus hyphae to inflammatory foci, leading to widespread hyphal dissemination to lung blood vessels.

  6. AIM2 reduced Akt (show AKT1 Antibodies) activation and tumor burden in colorectal cancer models, while an Akt (show AKT1 Antibodies) inhibitor reduced tumor load in Aim2(-/-) mice

  7. For the first time, this paper demonstrated that miR (show MLXIP Antibodies)-223 acted to inhibit IL-1beta (show IL1B Antibodies) production via AIM2 pathway, suppressing Kupffer cells pro-inflammatory activation at the early stage of ALF (show GTF2A1L Antibodies). Thus, it played an important role in the pathogenesis of ALF (show GTF2A1L Antibodies).

  8. Study found that Aim2-deficient mice were hypersusceptible to colonic tumor development. Production of inflammasome-associated cytokines and other inflammatory mediators was largely intact in Aim2-deficient mice; however, intestinal stem cells were prone to uncontrolled proliferation.

  9. The comparison shows mouse AIM2 PYD domain adopts a unique alpha2-alpha3 helix conformation distinct from its human homologues, but similar to the pyrin (show MEFV Antibodies) domain of human NLRP10/PYNOD (show NLRP10 Antibodies), which belongs to another family.

  10. these results reveal a specific requirement for IRF1 (show IRF1 Antibodies) and GBPs in the liberation of DNA for sensing by AIM2 depending on the pathogen encountered by the cell.

AIM2 Antigen Profile

Protein Summary

AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.

Gene names and symbols associated with AIM2

  • absent in melanoma 2 (AIM2) antibody
  • absent in melanoma 2 (Aim2) antibody
  • AIM2 antibody
  • Gm1313 antibody
  • Ifi210 antibody
  • PYHIN4 antibody

Protein level used designations for AIM2

absent in melanoma 2 , interferon-inducible protein AIM2-like , interferon-inducible protein AIM2 , ifi-210 , interferon-inducible protein 210 , interferon-inducible protein p210

GENE ID SPECIES
457425 Pan troglodytes
100459446 Pongo abelii
719260 Macaca mulatta
9447 Homo sapiens
383619 Mus musculus
304987 Rattus norvegicus
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