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Acetyl-CoA Acetyltransferase 1 Proteins (ACAT1)

ACAT1 encodes a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Additionally we are shipping ACAT1 Antibodies (150) and ACAT1 Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ACAT1 38 P24752
ACAT1 25014 P17764
ACAT1 110446 Q8QZT1
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Top ACAT1 Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$3,067.17
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$3,067.17
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,089.17
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$3,089.17
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,089.17
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$413.21
Details

ACAT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Rat (Rattus)

Mouse (Murine)

Top referenced ACAT1 Proteins

  1. Human ACAT1 Protein expressed in Escherichia coli (E. coli) - ABIN1098453 : Thompson, Krisans: Rat liver peroxisomes catalyze the initial step in cholesterol synthesis. The condensation of acetyl-CoA units into acetoacetyl-CoA. in The Journal of biological chemistry 1990 (PubMed)
    Show all 2 references for ABIN1098453

More Proteins for Acetyl-CoA Acetyltransferase 1 (ACAT1) Interaction Partners

Human Acetyl-CoA Acetyltransferase 1 (ACAT1) interaction partners

  1. compound heterozygous of ACAT1 gene mutations probably underlie the beta-ketothiolase deficiency in our patient

  2. ACAT1 regulates glioblastoma-cell proliferation via modification of the Akt and/or the ERK1/2 pathway.

  3. Data indicate that acetyl-CoA (show LPCAT2 Proteins) acetyltransferase (ACAT1) and malate dehydrogenase (MDH2 (show MDH Proteins)) are involved in various drug-resistance-forming mechanisms.

  4. ACAT1, ACACA, ALDH6A1 (show ALDH6A1 Proteins) and MTHFD1 (show MTHFD1 Proteins) represent novel biomarkers in adipose tissue associated with type 2 diabetes in obese individuals.

  5. Data show that the C allele of acyl-CoA (show GNPAT Proteins) acyltransferase-1 (ACAT-1) rs1044925 was associated with a decreased risk of coronary artery disease and ischemic stroke patients.

  6. Acat1 gene knock-out increases phagocytic uptake of amyloid beta-protein (1 (show DLX4 Proteins)-42).

  7. Induction of apoptosis and necroptosis by 24(S)-hydroxycholesterol is dependent on activity ACAT1.

  8. the enzyme activity of ACAT1 with Gln526 is less active than that of ACAT1 with Arg526 by 40%; Pro347 located near transmembrane domain 5 plays an important role in modulating enzyme catalysis

  9. the pyruvate dehydrogenase (show PDP Proteins) complex is regulated by Tyr (show TYR Proteins) phosphorylation of PDP1 (show PDP Proteins), which toggles recruitment between ACAT1 and SIRT3 (show SIRT3 Proteins)

  10. these findings indicate that ACAT1 expression could serve as a potential prognostic marker in prostate cancer, specifically in differentiating indolent and aggressive forms of cancer.

Mouse (Murine) Acetyl-CoA Acetyltransferase 1 (ACAT1) interaction partners

  1. In a mouse model, targeting ACAT1 (show SOAT1 Proteins) specifically in a myeloid lineage may benefit atherosclerosis progression by reducing the infiltration of foamy macrophages.

  2. Oxidized low-density lipoprotein activated the TLR4 (show TLR4 Proteins)/MyD88 (show MYD88 Proteins)/NF-kappaB (show NFKB1 Proteins) inflammatory signaling pathway in vascular smooth muscle cell, which upregulates the ACAT1 (show SOAT1 Proteins) expression and promotes VSMC foam cell formation.

  3. Exacerbation of liver fibrosis by ACAT1 (show SOAT1 Proteins) deficiency was dependent on free cholesterol accumulation-induced enhancement of TLR4 (show TLR4 Proteins) signaling.

  4. ACAT1 (show SOAT1 Proteins) plays important roles in hematopoiesis in normal mouse and in Apoe (show APOE Proteins)(-/-) mouse during atherosclerosis development.

  5. ApoA-I (show APOA1 Proteins) Helsinki promotes accumulation of ACAT1 (show SOAT1 Proteins) in a mouse macrophage cell line.

  6. the plaque-modulating effects of K-604 can be explained by stimulation of procollagen production independent of ACAT (show SOAT1 Proteins) inhibition in addition to potent inhibition of macrophage ACAT-1 (show SOAT1 Proteins)

  7. ACAT1 (show SOAT1 Proteins) gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with Alzheimer disease.

  8. ACAT1 displays less capacity than ACAT2 to differentiate cholesterol from sitosterol

  9. ACAT1 (show SOAT1 Proteins) knockout macrophages show biochemical changes consistent with increased cytotoxicity and also a novel association with decreased expression of collagen type 3A1.

  10. Deficiency of macrophage ACAT1 (show SOAT1 Proteins) accelerates atherosclerosis in apoE (show APOE Proteins)-/- mice but has no effect when hypercholesterolemia is corrected by apoE (show APOE Proteins) expression. ACAT1 (show SOAT1 Proteins) deletion impairs ABCA1 (show ABCA1 Proteins)-mediated cholesterol efflux in macrophages regardless of apoE (show APOE Proteins) expression

ACAT1 Protein Profile

Protein Summary

This gene encodes a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in this gene are associated with 3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone.

Gene names and symbols associated with ACAT1

  • acetyl-CoA acetyltransferase 1 (ACAT1)
  • acetyl-CoA acetyltransferase 1 (Acat1)
  • acetyl-CoA acetyltransferase 1 (acat1)
  • acetyl-Coenzyme A acetyltransferase 1 (Acat1)
  • acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) (acat1)
  • 6330585C21Rik protein
  • Acat protein
  • acat1-a protein
  • fd16h07 protein
  • fd20g06 protein
  • MAT protein
  • RATACAL protein
  • T2 protein
  • THIL protein
  • wu:fd16h07 protein
  • wu:fd20g06 protein
  • zgc:86832 protein

Protein level used designations for ACAT1

acetyl-CoA acetyltransferase 1 , acetoacetyl Coenzyme A thiolase , acetoacetyl-CoA thiolase , acetyl-CoA acetyltransferase, mitochondrial , acetyl-Coenzyme A acetyltransferase 1 , mitochondrial acetoacetyl-CoA thiolase , acetyl-Co A acetyltransferase 1 mitochondrial , acetyl-coenzyme A acetyltransferase 1 , Acetoacetyl-CoA thiolase A , acetyl-CoA acetyltransferase A, mitochondrial , acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase)

GENE ID SPECIES
100597123 Nomascus leucogenys
100626793 Sus scrofa
38 Homo sapiens
25014 Rattus norvegicus
414639 Xenopus laevis
418968 Gallus gallus
511082 Bos taurus
489421 Canis lupus familiaris
110446 Mus musculus
445290 Danio rerio
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