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Acetyl-CoA Acetyltransferase 2 Proteins (ACAT2)

The product of ACAT2 is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. Additionally we are shipping ACAT2 Antibodies (78) and ACAT2 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ACAT2 39 Q9BWD1
Rat ACAT2 ACAT2 308100 Q5XI22
ACAT2 110460 Q8CAY6
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Top ACAT2 Proteins at antibodies-online.com

Showing 6 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 3 to 4 Days
$3,035.21
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$364.64
Details

ACAT2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Top referenced ACAT2 Proteins

  1. Human ACAT2 Protein expressed in Escherichia coli (E. coli) - ABIN667155 : Alger, Brown, Sawyer, Kelley, Shah, Wilson, Willingham, Rudel: Inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) prevents dietary cholesterol-associated steatosis by enhancing hepatic triglyceride mobilization. in The Journal of biological chemistry 2010 (PubMed)
    Show all 2 references for ABIN667155

More Proteins for Acetyl-CoA Acetyltransferase 2 (ACAT2) Interaction Partners

Human Acetyl-CoA Acetyltransferase 2 (ACAT2) interaction partners

  1. results show that the enzymatic activity of mutant Glu(14)Gly is approximately two times higher than wildtype, and that this increase is primarily due to the increased expression and/or stability of the mutant ACAT2 protein

  2. Results show that DLAT (show DLAT Proteins) and ACAT2 as upstream acetyltransferases of K76 and K294 in 6PGD (show PGD Proteins) protein.

  3. Reduced ACAT2 is associated with impaired butyrate oxidation in ulcerative colitis.

  4. HNF4alpha positively regulates ACAT2 gene expression at mRNA level. Overexpression of HNF4alpha increased ACAT2 expression, whereas knockdown of HNF4alpha decreased ACAT2 expression.

  5. Describe a gender-related difference in hepatic ACAT2 activity in normolipidemic non-obese Chinese patients suggesting a possible role for ACAT2 in the regulation of cholesterol metabolism in humans.

  6. Data describe the high resolution structure of human cytosolic acetoacetyl-CoA thiolase (CT), both unliganded (at 2.3 angstroms resolution) and in complex with CoA (at 1.6 angstroms resolution).

  7. human ACAT2 is transcriptionally regulated by cholesterol.

  8. ACAT2 expression was induced upon R1881 (androgen agonist) treatment in prostate cancer cells

  9. ACAT-2 expression was negative in clear cell type renal cell carcinoma (show MOK Proteins) and normal kidney.

  10. The increased NPC1L1 and ACAT2 mRNA levels in gallstone patients might indicate an upregulated absorption and esterification of cholesterol in the small intestine.

Mouse (Murine) Acetyl-CoA Acetyltransferase 2 (ACAT2) interaction partners

  1. Intestine-specific MTP (show LAPTM4A Proteins) and global ACAT2 (show SOAT2 Proteins) deficiency lowers acute cholesterol absorption with chylomicrons and HDLs (show CSF1R Proteins)

  2. ACAT2 (show SOAT2 Proteins) seems to be a hepatic player affecting the cholesterol fluxes fated to VLDL or to HDL (show HSD11B1 Proteins), the latter via up-regulation of ABCA1 (show ABCA1 Proteins)

  3. handling of sterols by the intestine involves both G5G8 and ACAT2 but that an additional factor (possibly Niemann-Pick C1-like 1) may be key in determining absorption efficiency

  4. inhibition of intestinal or hepatic ACAT2 improves atherogenic hyperlipidemia and limits hepatic cholesteryl ester accumulation

  5. Pyripyropene ACAT2-selective inhibition in the intestine and the liver can be effective against atherosclerosis.

  6. Inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (show SOAT2 Proteins) prevents dietary cholesterol-associated steatosis by enhancing hepatic triglyceride mobilization.

  7. ACAT2 (show SOAT2 Proteins) provides core CE of newly secreted VLDL, whereas LCAT (show LCAT Proteins) adds CE during LDL particle formation

  8. ABCA1 (show ABCA1 Proteins), especially in the absence of ACAT2 (show SOAT2 Proteins), can have a significant effect on cholesterol absorption, although ACAT2 (show SOAT2 Proteins) has a more substantial role in this process than ABCA1 (show ABCA1 Proteins)

  9. depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol loss

ACAT2 Protein Profile

Protein Summary

The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation.

Gene names and symbols associated with ACAT2

  • acetyl-CoA acetyltransferase 2 (ACAT2)
  • acetyl-CoA acetyltransferase 2 (Acat2)
  • acetyl-Coenzyme A acetyltransferase 2 (Acat2)
  • Ab2-076 protein
  • Acat3 protein
  • AW742799 protein
  • Tcp-1x protein
  • Tcp1-rs1 protein

Protein level used designations for ACAT2

acetoacetyl Coenzyme A thiolase , acetyl-CoA acetyltransferase, cytosolic , acetyl-CoA transferase-like protein , cytosolic acetoacetyl-CoA thiolase , acetyl-Coenzyme A acetyltransferase 2 , acetyl-Coenzyme A acetyltransferase 3 , acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) , t-complex protein 1, related sequence 1

GENE ID SPECIES
39 Homo sapiens
512044 Bos taurus
308100 Rattus norvegicus
484063 Canis lupus familiaris
110460 Mus musculus
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