Acetyl-CoA Acetyltransferase 2 Proteins (ACAT2)

The product of ACAT2 is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. Additionally we are shipping ACAT2 Antibodies (109) and ACAT2 Kits (28) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ACAT2 39 Q9BWD1
ACAT2 110460 Q8CAY6
ACAT2 308100 Q5XI22
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Top ACAT2 Proteins at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Escherichia coli (E. coli) Human His tag,TRX tag   50 μg Log in to see 4 Days
$522.50
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HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 2 to 3 Days
$3,035.21
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HOST_Escherichia coli (E. coli) Rat His tag SDS-PAGE 100 μg Log in to see 20 to 21 Days
$496.65
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HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 15 to 18 Days
$656.00
Details
HOST_Escherichia coli (E. coli) Mouse S tag,His tag   100 μg Log in to see 15 to 18 Days
$704.00
Details

ACAT2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine) ,
,
Rat (Rattus)

More Proteins for Acetyl-CoA Acetyltransferase 2 (ACAT2) Interaction Partners

Human Acetyl-CoA Acetyltransferase 2 (ACAT2) interaction partners

  1. Lipid-induced stabilization of ACAT2 ameliorates lipotoxicity from excessive cholesterol and fatty acid. Cysteine ubiquitylation of ACAT2 constitutes an important mechanism for sensing lipid-overload-induced ROS and fine-tuning lip (show ROS1 Proteins)id homeostasis.

  2. data demonstrate that the ACAT2 expression of human leukocytes is responsible for the excretion of lipoproteins containing cholesteryl/steryl esters (CE/SE), and suggest that the excretion of lipoproteins containing the ACAT2-catalyzed CS/SE may avoid cytotoxicity

  3. results demonstrate that the low-level expression of human ACAT2 gene with specific CpG-hypomethylated promoter is regulated by the C/EBP transcription factors in monocytic cells, and imply that the lowly expressed ACAT2 catalyzes the synthesis of certain CE/SE that are assembled into lipoproteins for the secretion

  4. Low ACAT2 expression is associated with clear cell renal cell carcinoma (show MOK Proteins).

  5. results show that the enzymatic activity of mutant Glu(14)Gly is approximately two times higher than wildtype, and that this increase is primarily due to the increased expression and/or stability of the mutant ACAT2 protein

  6. Results show that DLAT (show DLAT Proteins) and ACAT2 as upstream acetyltransferases of K76 and K294 in 6PGD (show PGD Proteins) protein.

  7. Reduced ACAT2 is associated with impaired butyrate oxidation in ulcerative colitis.

  8. HNF4alpha positively regulates ACAT2 gene expression at mRNA level. Overexpression of HNF4alpha increased ACAT2 expression, whereas knockdown of HNF4alpha decreased ACAT2 expression.

  9. Describe a gender-related difference in hepatic ACAT2 activity in normolipidemic non-obese Chinese patients suggesting a possible role for ACAT2 in the regulation of cholesterol metabolism in humans.

  10. Data describe the high resolution structure of human cytosolic acetoacetyl-CoA thiolase (CT), both unliganded (at 2.3 angstroms resolution) and in complex with CoA (at 1.6 angstroms resolution).

Mouse (Murine) Acetyl-CoA Acetyltransferase 2 (ACAT2) interaction partners

  1. lipid-induced stabilization of ACAT2 (show SOAT2 Proteins) ameliorates lipotoxicity from excessive cholesterol and fatty acid. This unconventional cysteine ubiquitylation of ACAT2 (show SOAT2 Proteins) constitutes an important mechanism for sensing lipid-overload-induced ROS (show ROS1 Proteins) and fine-tuning lipid homeostasis.

  2. Intestine-specific MTP (show LAPTM4A Proteins) and global ACAT2 (show SOAT2 Proteins) deficiency lowers acute cholesterol absorption with chylomicrons and HDLs (show CSF1R Proteins)

  3. ACAT2 (show SOAT2 Proteins) seems to be a hepatic player affecting the cholesterol fluxes fated to VLDL or to HDL (show HSD11B1 Proteins), the latter via up-regulation of ABCA1 (show ABCA1 Proteins)

  4. handling of sterols by the intestine involves both G5G8 and ACAT2 but that an additional factor (possibly Niemann-Pick C1-like 1) may be key in determining absorption efficiency

  5. inhibition of intestinal or hepatic ACAT2 improves atherogenic hyperlipidemia and limits hepatic cholesteryl ester accumulation

  6. Pyripyropene ACAT2-selective inhibition in the intestine and the liver can be effective against atherosclerosis.

  7. Inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (show SOAT2 Proteins) prevents dietary cholesterol-associated steatosis by enhancing hepatic triglyceride mobilization.

  8. ACAT2 (show SOAT2 Proteins) provides core CE of newly secreted VLDL, whereas LCAT (show LCAT Proteins) adds CE during LDL particle formation

  9. ABCA1 (show ABCA1 Proteins), especially in the absence of ACAT2 (show SOAT2 Proteins), can have a significant effect on cholesterol absorption, although ACAT2 (show SOAT2 Proteins) has a more substantial role in this process than ABCA1 (show ABCA1 Proteins)

  10. depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol loss

Arabidopsis thaliana Acetyl-CoA Acetyltransferase 2 (ACAT2) interaction partners

  1. The AACT2-derived acetoacetyl CoA pool generates isoprenoids that are required for normal growth and development. AACT2 is essential and cannot be replaced by AACT1. AACT1 and AACT2 exhibit differential spatial and temporal expression patterns.

Pig (Porcine) Acetyl-CoA Acetyltransferase 2 (ACAT2) interaction partners

  1. ACAT2 might contribute more to metabolic processes than ACAA2 (show ACAA2 Proteins) in swine.

ACAT2 Protein Profile

Protein Summary

The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation.

Gene names and symbols associated with ACAT2

  • acetyl-CoA acetyltransferase 2 (ACAT2)
  • acetyl-CoA acyltransferase 2 (acaa2)
  • acetyl-Coenzyme A acyltransferase 2 (CNA05060)
  • acetyl-CoA acyltransferase 2 (ACAA2)
  • acetyl-coenzyme A acyltransferase 2 (LOC100232412)
  • acetyl-CoA acetyltransferase 2 (acat2)
  • acetyl-Coenzyme A acetyltransferase 2 (Acat2)
  • acetyl-CoA acetyltransferase 2 (Acat2)
  • acetoacetyl-CoA thiolase 2 (ACAT2)
  • acetoacetyl-CoA thiolase 2, embryo defective 1276 (ACAT2)
  • Acetyl-CoA acetyltransferase, cytosolic (thic)
  • Acetyl-Coenzyme A acetyltransferase 2 (LOC100152303)
  • acetyl-coenzyme A acyltransferase 2 (LOC100339733)
  • Acetyl-Coenzyme A acetyltransferase 2-like (LOC100340500)
  • Ab2-076 protein
  • Acat3 protein
  • acetoacetyl-CoA thiolase 2 protein
  • AW742799 protein
  • EMB1276 protein
  • EMBRYO DEFECTIVE 1276 protein
  • fb10a06 protein
  • fb53f08 protein
  • fb59b11 protein
  • MIF21.12 protein
  • MIF21_12 protein
  • Tcp-1x protein
  • Tcp1-rs1 protein
  • wu:fb10a06 protein
  • wu:fb53f08 protein
  • wu:fb59b11 protein
  • zgc:56036 protein

Protein level used designations for ACAT2

acetoacetyl Coenzyme A thiolase , acetyl-CoA acetyltransferase, cytosolic , acetyl-CoA transferase-like protein , cytosolic acetoacetyl-CoA thiolase , acetyl-Coenzyme A acyltransferase 2 , 3-ketoacyl-CoA thiolase, mitochondrial , beta-ketothiolase , mitochondrial 3-oxoacyl-CoA thiolase , acetyl-coenzyme A acyltransferase 2 , etID39354.20 , t-complex protein 1, related sequence 1 , acetyl-Coenzyme A acetyltransferase 2 , acetyl-Coenzyme A acetyltransferase 3 , acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) , acetoacetyl-CoA thiolase 2, embryo defective 1276 , acetyl-CoA acetyltransferase 2 , acetyl-CoA acetyltransferase, cytosolic-like , Acetyl-CoA acetyltransferase, cytosolic

GENE ID SPECIES
39 Homo sapiens
779631 Xenopus (Silurana) tropicalis
3253349 Cryptococcus neoformans var. neoformans JEC21
100171644 Pongo abelii
100231849 Taeniopygia guttata
100232412 Taeniopygia guttata
30643 Danio rerio
110460 Mus musculus
308100 Rattus norvegicus
394562 Xenopus (Silurana) tropicalis
398120 Xenopus laevis
421587 Gallus gallus
484063 Canis lupus familiaris
497249 Monodelphis domestica
512044 Bos taurus
708750 Macaca mulatta
834876 Arabidopsis thaliana
9299957 Arabidopsis lyrata subsp. lyrata
100172365 Pongo abelii
100410799 Callithrix jacchus
100477493 Ailuropoda melanoleuca
100194920 Salmo salar
406325 Danio rerio
709350 Macaca mulatta
100069345 Equus caballus
100152303 Sus scrofa
100339733 Oryctolagus cuniculus
100340500 Oryctolagus cuniculus
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