anti-Acetyl-Coenzyme A Acetyltransferase 1 (ACAT1) Antibodies

The protein encoded by ACAT1 belongs to the acyltransferase family.

list all antibodies Gene Name GeneID UniProt
Anti-Human ACAT1 ACAT1 38 P24752
Anti-Rat ACAT1 ACAT1 25014 P17764
Anti-Mouse ACAT1 ACAT1 110446 Q8QZT1
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More Antibodies against Acetyl-Coenzyme A Acetyltransferase 1 Interaction Partners

Human Acetyl-Coenzyme A Acetyltransferase 1 (ACAT1) interaction partners

  1. these results illustrate that ACAT1-catalyzed esterification of 24S-OHC with long-chain unsaturated fatty acid followed by formation of atypical LD-like structures at the ER membrane is a critical requirement for 24S-OHC-induced cell death.

  2. ACAT1 exonic mutations that affect ESE sequences may result in aberrant splicing. This may affect the activity of mitochondrial acetoacetyl-CoA thiolase.

  3. TLR4 (show TLR4 Antibodies) siRNA inhibits cell proliferation, migration and invasion by suppressing ACAT1 expression, suggesting that TLR4 (show TLR4 Antibodies) may be a potential therapeutic target for the treatment of colorectal cancer

  4. ACAT1 has a role in regulating the dynamics of free cholesterols in plasma membrane which leads to the APP (show APP Antibodies)-alpha-processing alteration

  5. compound heterozygous of ACAT1 gene mutations probably underlie the beta-ketothiolase deficiency in our patient

  6. ACAT1 regulates glioblastoma-cell proliferation via modification of the Akt (show AKT1 Antibodies) and/or the ERK1/2 (show MAPK1/3 Antibodies) pathway.

  7. Data indicate that mitotane confers adrenal-specific cytotoxicity and down-regulates steroidogenesis by inhibition of sterol-O-acyl-transferase 1 (SOAT1 (show SOAT1 Antibodies)) leading to lipid-induced endoplasmic reticulum (ER) stress.

  8. Data indicate that acetyl-CoA (show LPCAT2 Antibodies) acetyltransferase (ACAT1) and malate dehydrogenase (MDH2 (show MDH Antibodies)) are involved in various drug-resistance-forming mechanisms.

  9. Suggest retinal pigment epithelium metabolism of 7-ketocholesterol occurs by esterification to fatty acids via cPLA2alpha (show PLA2G4A Antibodies) and SOAT1 (show SOAT1 Antibodies) followed by selective efflux to HDL (show HSD11B1 Antibodies).

  10. ACAT1, ACACA (show ACACA Antibodies), ALDH6A1 (show ALDH6A1 Antibodies) and MTHFD1 (show MTHFD1 Antibodies) represent novel biomarkers in adipose tissue associated with type 2 diabetes in obese individuals.

Mouse (Murine) Acetyl-Coenzyme A Acetyltransferase 1 (ACAT1) interaction partners

  1. Data show that microRNA miR (show MLXIP Antibodies)-467b regulates the acetyl-CoA acetyltransferase 1 (ACAT1) expression via targeting ACAT1 (show SOAT1 Antibodies) 3' untranslated regions (3'UTR (show UTS2R Antibodies)).

  2. In a mouse model, targeting ACAT1 (show SOAT1 Antibodies) specifically in a myeloid lineage may benefit atherosclerosis progression by reducing the infiltration of foamy macrophages.

  3. Oxidized low-density lipoprotein activated the TLR4 (show TLR4 Antibodies)/MyD88 (show MYD88 Antibodies)/NF-kappaB (show NFKB1 Antibodies) inflammatory signaling pathway in vascular smooth muscle cell, which upregulates the ACAT1 (show SOAT1 Antibodies) expression and promotes VSMC foam cell formation.

  4. Exacerbation of liver fibrosis by ACAT1 (show SOAT1 Antibodies) deficiency was dependent on free cholesterol accumulation-induced enhancement of TLR4 (show TLR4 Antibodies) signaling.

  5. ACAT1 (show SOAT1 Antibodies) plays important roles in hematopoiesis in normal mouse and in Apoe (show APOE Antibodies)(-/-) mouse during atherosclerosis development.

  6. ApoA-I (show APOA1 Antibodies) Helsinki promotes accumulation of ACAT1 (show SOAT1 Antibodies) in a mouse macrophage cell line.

  7. the plaque-modulating effects of K-604 can be explained by stimulation of procollagen production independent of ACAT (show SOAT1 Antibodies) inhibition in addition to potent inhibition of macrophage ACAT-1 (show SOAT1 Antibodies)

  8. ACAT1 (show SOAT1 Antibodies) gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with Alzheimer disease.

  9. ACAT1 displays less capacity than ACAT2 to differentiate cholesterol from sitosterol

  10. ACAT1 (show SOAT1 Antibodies) knockout macrophages show biochemical changes consistent with increased cytotoxicity and also a novel association with decreased expression of collagen type 3A1.

Acetyl-Coenzyme A Acetyltransferase 1 (ACAT1) Antigen Profile

Protein Summary

The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with ACAT1

  • acetyl-CoA acetyltransferase 1 (ACAT1) antibody
  • acetyl-CoA acetyltransferase 1 (acat1) antibody
  • acetyl-Coenzyme A acetyltransferase 1 (ACAT1) antibody
  • acetyl-CoA acetyltransferase 1 (Acat1) antibody
  • acetyl-Coenzyme A acetyltransferase 1 (Acat1) antibody
  • sterol O-acyltransferase 1 (SOAT1) antibody
  • 6330585C21Rik antibody
  • ACACT antibody
  • Acat antibody
  • ACAT-1 antibody
  • ACAT1 antibody
  • MAT antibody
  • RATACAL antibody
  • SOAT antibody
  • STAT antibody
  • T2 antibody
  • THIL antibody

Protein level used designations for ACAT1

acetyl-CoA acetyltransferase, mitochondrial , acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) , Acetoacetyl-CoA thiolase , acetyl-Coenzyme A acetyltransferase 1 , acyl-CoA:cholesterol acyltransferase , acetyl-CoA acetyltransferase 1 , acetyl-CoA acetyltransferase, mitochondrial-like , acetoacetyl Coenzyme A thiolase , acetoacetyl-CoA thiolase , mitochondrial acetoacetyl-CoA thiolase , acetyl-Co A acetyltransferase 1 mitochondrial , acetyl-coenzyme A acetyltransferase 1 , acyl-coenzyme A:cholesterol acyltransferase 1 , sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1

GENE ID SPECIES
451528 Pan troglodytes
594960 Xenopus (Silurana) tropicalis
707653 Macaca mulatta
100009537 Oryctolagus cuniculus
100448951 Pongo abelii
38 Homo sapiens
25014 Rattus norvegicus
110446 Mus musculus
6646 Homo sapiens
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