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Acid Phosphatase, Prostate Proteins (ACPP)

ACPP encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. Additionally we are shipping ACPP Antibodies (193) and ACPP Kits (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ACPP 58813  
ACPP 70881 Q91YE9
ACPP 55 P15309
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Top ACPP Proteins at antibodies-online.com

Showing 10 out of 22 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Human Human Un-conjugated   100 μg Log in to see 7 to 9 Days
$170.36
Details
HOST_Human Human Un-conjugated   1 mg Log in to see 7 to 9 Days
$170.36
Details
HOST_Human Cells Human His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 16 Days
$437.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,951.67
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,960.83
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,986.50
Details

ACPP Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Mouse (Murine) ,

Human , , , ,
,

Top referenced ACPP Proteins

  1. Human ACPP Protein expressed in Human - ABIN934762 : Drake, White, Fuller, Igwe, Clements, Nyalwidhe, Given, Lance, Semmes: Clinical collection and protein properties of expressed prostatic secretions as a source for biomarkers of prostatic disease. in Journal of proteomics 2009 (PubMed)

More Proteins for Acid Phosphatase, Prostate (ACPP) Interaction Partners

Pig (Porcine) Acid Phosphatase, Prostate (ACPP) interaction partners

  1. The obtained N-terminal amino-acid sequence of boar PTAP showed 92% identity with the N-terminal amino-acid sequence of human PAP (show PDAP1 Proteins). The determined sequence of a 354 bp nucleotide fragment showed 90% identity with the corresponding sequence of human PAP (show PDAP1 Proteins).

Mouse (Murine) Acid Phosphatase, Prostate (ACPP) interaction partners

  1. TMPAP is involved in the control of GABAergic tone in the brain also through exocytosis, and that PAP (show ASAP1 Proteins) deficiency produces a distinct neurological phenotype.

  2. In male mouse saliva (show RAG1AP1 Proteins) prostatic acid phosphatase regulates salivation.

  3. Data indicate that prostate acid phosphatase-based peptide vaccine PAP (show ASAP1 Proteins)-114-128 peptide appears to be a relevant for the treatment of prostate cancer.

  4. this PAP (show ASAP1 Proteins)-/- mouse model shows that TMPAP is required for the normal function of prostate in mice, and its deficiency leads to prostate adenocarcinoma.

  5. Both prostatic acid phosphatase and ecto-5'-nucleotidase generate adenosine in the dorsal spinal cord.

  6. Prostatic acid phosphatase is required for the antinociceptive effects of thiamine and benfotiamine.

  7. Experiments indicate that PAP (show ASAP1 Proteins) and NT5E (show NT5E Proteins) are the main ectonucleotidases that generate adenosine in nociceptive circuits and indicate these enzymes transform pulsatile or sustained nucleotide release into an inhibitory adenosinergic signal.

  8. prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 (show ERBB2 Proteins) and regulates prostate cancer cell growth

  9. studies highlight similarities and differences in PAP (show ASAP1 Proteins) localization within nociceptive neurons of mice and rats

  10. PAP (show ASAP1 Proteins) has species-conserved antinociceptive effects and has pH-dependent ectonucleotidase activity

Human Acid Phosphatase, Prostate (ACPP) interaction partners

  1. Prostatic acid phosphatase delays prostate cancer cell growth in G1 phase of the cell cycle.

  2. Studies suggest that understanding of prostatic acid phosphatase function and regulation of expression will have a significant impact on understanding prostate cancer (PCa (show FLVCR1 Proteins)) progression and therapy.

  3. Certain factors identified within semen, termed semen-derived enhancers of virus infection (SEVI), fragments of prostatic acid phosphatase, have been shown to significantly enhance HIV-1 infectivity.

  4. ACPP increases significantly in epithelial cells of ovarian carcinoma, which indicates that it may be a candidate biomarker for diagnosis of epithelia-derived ovarian cancer in women.

  5. Data indicate that hypoxia regulates prostatic acid phosphatase (PAP) through hypoxia-inducible factor 2 alpha (show EPAS1 Proteins) (HIF2alpha (show EPAS1 Proteins)) and from stimulated A2B (show ADORA2B Proteins) adenosine receptors.

  6. GCNT1 (show GCNT1 Proteins) is over-expressed in prostate cancer and is associated with higher levels of core 2 O-sLe(x) in PSA (show PLAG1 Proteins), PAP (show REG3A Proteins) and MUC1 (show MUC1 Proteins) proteins.

  7. Data indicate that prostate acid phosphatase-based peptide vaccine PAP (show REG3A Proteins)-114-128 peptide appears to be a relevant for the treatment of prostate cancer.

  8. Soluble ecto-5'-nucleotidase (5'-NT), alkaline phosphatase, and adenosine deaminase (ADA1 (show ADA Proteins)) activities in neonatal blood favor elevated extracellular adenosine.

  9. in the in vivo environment, PAP (show REG3A Proteins)(248-286) is likely to form fibrils efficiently, thus providing an explanation for the presence of semen-derived enhancer of viral infection in human semen.

  10. Peptide fragments derived from N-proximal and C-proximal of the PAP (show REG3A Proteins) form fibrillar structures and increase virion attachment to cells.

ACPP Protein Profile

Protein Summary

This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with ACPP

  • acid phosphatase, prostate (ACPP)
  • acid phosphatase, prostate (LOC100352974)
  • prostatic acid phosphatase (CpipJ_CPIJ004002)
  • prostatic acid phosphatase (CpipJ_CPIJ017646)
  • prostatic acid phosphatase (Smp_016640)
  • 5' nucleotidase, ecto (Nt5e)
  • 5'-nucleotidase, cytosolic IB (Nt5c1b)
  • acid phosphatase, prostate (Acpp)
  • acid phosphatase, prostate (acpp)
  • ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (ASAP2)
  • 5'-NT protein
  • 4921514H13Rik protein
  • A030005E02Rik protein
  • acp-3 protein
  • acp3 protein
  • ACPP protein
  • Acpp11 protein
  • acpt protein
  • AIRP protein
  • AMAP2 protein
  • CD73 protein
  • CENTB3 protein
  • CN-IB protein
  • DDEF2 protein
  • FRAP protein
  • Lap protein
  • Nt5 protein
  • PAG3 protein
  • pap protein
  • Pap-alpha protein
  • Ppal protein
  • RNACPP11 protein
  • SHAG1 protein

Protein level used designations for ACPP

prostatic acid phosphatase , acid phosphatase, prostate , tyrosine acid phosphatase , prostatic acid phosphatase-like , 5'-NT , 5'-nucleotidase , ecto-5'-nucleotidase , 5'nucleotidase , autoimmune infertility-related protein , cN1B , cytosolic 5'-nucleotidase 1B , cytosolic 5'-nucleotidase IB , TMPase , prostatic acid phosphotase , thiamine monophosphatase , fluoride-resistant acid phosphatase , lysosomal acid phosphatase , prostatic acid phosphatase (rPAP) , testicular acid phosphatase homolog , PYK2 C terminus-associated protein , arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 , centaurin, beta 3 , development and differentiation enhancing factor 2 , development and differentiation-enhancing factor 2 , paxillin-associated protein with ARF GAP activity 3 , pyk2 C-terminus-associated protein

GENE ID SPECIES
460702 Pan troglodytes
717786 Macaca mulatta
776390 Gallus gallus
100302507 Sus scrofa
100352974 Oryctolagus cuniculus
100407634 Callithrix jacchus
100439440 Pongo abelii
6035387 Culex quinquefasciatus
6051825 Culex quinquefasciatus
8349859 Schistosoma mansoni
100590181 Nomascus leucogenys
58813 Rattus norvegicus
70881 Mus musculus
55 Homo sapiens
485662 Canis lupus familiaris
56318 Mus musculus
56780 Rattus norvegicus
504700 Bos taurus
446918 Xenopus laevis
8853 Homo sapiens
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