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Acid phosphatases are enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. Additionally we are shipping ACPT Antibodies (14) and ACPT Kits (1) and many more products for this protein.
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ACPT inhibits cell proliferation through beta-catenin (show CTNNB1 Proteins)-mediated signaling in dental mesenchyme but elicits odontoblast differentiation and mineralization by supplying phosphate during dentin formation.
ACPT biallelic mutations caused non-syndromic, generalized hypoplastic autosomal-recessive amelogenesis imperfecta in individuals from six unrelated Turkish families. Analysis of the ACPT crystal structure suggests that these mutations damaged the activity of ACPT by altering the sizes and charges of key amino acid side chains, limiting accessibility of the catalytic core, and interfering with homodimerization.
Acid phosphatases are enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. This gene is up-regulated by androgens and is down-regulated by estrogens in the prostate cancer cell line. This gene exhibits a lower level of expression in testicular cancer tissues than in normal tissues. The protein encoded by this gene has structural similarity to prostatic and lysosomal acid phosphatases. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
acid phosphatase, testicular
, testicular acid phosphatase
, testicular acid phosphatase-like