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anti-Aconitase 1, Soluble (ACO1) Antibodies

Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). Additionally we are shipping Aconitase 1 Kits (11) and Aconitase 1 Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ACO1 11428 P28271
ACO1 48 P21399
ACO1 50655 Q63270
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Top anti-Aconitase 1 Antibodies at antibodies-online.com

Showing 10 out of 71 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-ACO1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Human kidney 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged ACO1 is approximately 0.3 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
REACT_Tomato Rabbit Un-conjugated WB 100 μL Log in to see 5 to 6 Days
$467.78
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from 293 cells treated with insulin 0.01U/ml 30', using IREB1 (Phospho-Ser711) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human thyroid gland, using IREB1 (Phospho-Ser711) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human ovary, using IREB1 (Phospho-Ser138) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Cow Goat Un-conjugated WB AP26015PU-N (0.1µg/ml) staining of Human Liver lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human thyroid gland tissue, using IREB1 (Ab-711) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using IREB1 (Ab-138) Antibody. The picture on the right is treated with the synthesized peptide. Immunofluorescence analysis of HeLa cells, using IREB1 (Ab-138) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated IP, ELISA, WB Detection limit for recombinant GST tagged ACO1 is approximately 0.3ng/ml as a capture antibody. Immunoprecipitation of ACO1 transfected lysate using anti-ACO1 monoclonal antibody and Protein A Magnetic Bead , and immunoblotted with ACO1 MaxPab rabbit polyclonal antibody. 100 μg Log in to see 9 Days
$430.00
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details

ACO1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) , , ,
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Rat (Rattus) , , ,
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Top referenced anti-Aconitase 1 Antibodies

  1. Human Monoclonal Aconitase 1 Primary Antibody for ELISA, WB - ABIN394119 : Yang, Liang, Pfeiffer, Wheeler, Maeder, Burdette, Yeager, Chanock, Tucker, Goldstein: Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. in Familial cancer 2010 (PubMed)
    Show all 5 references for ABIN394119

  2. Tomato (Solanum lycopersicum) Polyclonal Aconitase 1 Primary Antibody for WB - ABIN488534 : Bernard, Cheng, Zhao, Balk: An allelic mutant series of ATM3 reveals its key role in the biogenesis of cytosolic iron-sulfur proteins in Arabidopsis. in Plant physiology 2009 (PubMed)
    Show all 4 references for ABIN488534

  3. Human Monoclonal Aconitase 1 Primary Antibody for IP, ELISA - ABIN559748 : Reuter, Reiermann, Wörner, Schröter, Edemir, Buck, Henning, Peter-Katalinic, Vollenbröker, Amann, Pavenstädt, Schlatter, Gabriëls: IF/TA-related metabolic changes--proteome analysis of rat renal allografts. in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2010 (PubMed)

  4. Chicken Polyclonal Aconitase 1 Primary Antibody for IHC, WB - ABIN2778793 : Clarke, Vasanthakumar, Anderson, Pondarré, Koh, Deck, Pitula, Epstein, Fleming, Eisenstein: Iron-responsive degradation of iron-regulatory protein 1 does not require the Fe-S cluster. in The EMBO journal 2006 (PubMed)

More Antibodies against Aconitase 1 Interaction Partners

Pig (Porcine) Aconitase 1, Soluble (ACO1) interaction partners

  1. Iron increases turnover of ACO1 in kidney cells, while increasing aconitase (show ACO2 Antibodies) activity, suggesting that the apoprotein (show APOE Antibodies) (aconitase (show ACO2 Antibodies)-inactive) form is not exclusively responsible for turnover.

Mouse (Murine) Aconitase 1, Soluble (ACO1) interaction partners

  1. The Irp1-/- mice develop polycythemia and pulmonary hypertension, and suggesting that Irp1 plays an essential role in erythropoiesis and in the pulmonary and cardiovascular systems.

  2. IRP1 and IRP2 (show IREB2 Antibodies) mutant mice rapidly succumb to systemic infection with Salmonella Typhimurium, a pathogenic bacterium that multiplies within macrophages, with increased bacterial burdens in liver and spleen.

  3. results uncover an unexpected protective role of IRP1 in pathological conditions associated with altered Fe-S metabolism

  4. Aco1 KD in fully differentiated 3T3-L1 adipocytes decreased lipogenic, Idh1, Adipoq, and Glut4 gene expression.

  5. impaired mitochondrial [Fe-S] cluster biogenesis in Mfrn1 (show SLC25A37 Antibodies)(gt/gt (show FABP6 Antibodies)) cells results in elevated IRP1 RNA-binding that attenuates ALAS2 (show ALAS2 Antibodies) mRNA translation and protoporphyrin accumulation

  6. Data indicate that JTR-009, a benzimidazole, operated by preventing iron-regulatory protein-1 (IRP1) from binding to the iron-responsive element (IRE) in APP (show APP Antibodies) mRNA.

  7. Human ACO1 is a moonlighting protein that has both aco (show ACO2 Antibodies)nitase enzyme activity as well as an mRNA binding function.

  8. Aco1 is a moonlighting protein that has aconitase (show ACO2 Antibodies) activity as well as mRNA binding ability.

  9. IRP1 is the principal regulator of HIF2alpha (show EPAS1 Antibodies) mRNA translation

  10. Irp1 deletion enhanced HIF2alpha (show EPAS1 Antibodies) protein expression in kidneys of Irp1(-/-) mice.

Human Aconitase 1, Soluble (ACO1) interaction partners

  1. The SNP rs7874815 in the ACO1 gene was strongly associated with survival in pancreatic cancer.

  2. Our results confirm the observation that mitoNEET (show CISD1 Antibodies) is important in transferring the iron sulfur clusters to the cytosolic aconitase in living cells and the His-87 ligand in mitoNEET (show CISD1 Antibodies) plays important role in this process.

  3. Data show that IRP1 suppressed TfR1/DMT1 (+IRE) expression, limited the cellular iron content and decreased lactate dehydrogenase (LDH) release induced by hypoxia.

  4. These in vitro studies suggest that human GLRX3 (show GLRX3 Antibodies) is important for cytosolic Fe-S protein (show CDSN Antibodies) maturation.

  5. SIRT3 (show SIRT3 Antibodies) overexpression decreases TfR1 (show TFRC Antibodies) expression by inhibiting IRP1 and represses proliferation in pancreatic cancer cells.

  6. ACO1 gene expression was positively associated with adipogenic markers in subcutaneous and visceral adipose tissue.

  7. ACO1 genetic variation is associated with neuropathic pain and pain severity in HIV-infected patients on antiretroviral therapy

  8. MitoNEET (show CISD1 Antibodies) governs a novel trafficking pathway to rebuild an Fe-S cluster into cytosolic aconitase/IRP1.

  9. Polymer-dependent translocation of IRP-1 in Cd(2 (show CD2 Antibodies)+)-exposed cells may underlie effects of Cd(2 (show CD2 Antibodies)+) on iron homeostasis.

  10. Data indicate that JTR-009, a benzimidazole, operated by preventing iron-regulatory protein-1 (IRP1) from binding to the iron-responsive element (IRE) in APP (show APP Antibodies) mRNA.

Rabbit Aconitase 1, Soluble (ACO1) interaction partners

  1. Even though the base-specific RNA-binding residues are not part of the aconitase active site, their substitutions can affect the aconitase activity of holo-IRP1, positively or negatively.

Aconitase 1 (ACO1) Antigen Profile

Protein Summary

Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.

Gene names and symbols associated with ACO1

  • aconitase 1, soluble (ACO1) antibody
  • aconitase 1, soluble (aco1) antibody
  • aconitase 1, soluble (LOC100227513) antibody
  • 1-aminocyclopropane-1-carboxylate oxidase 1 (ACO1) antibody
  • aconitase 1 (Aco1) antibody
  • aconitase 1, soluble (Aco1) antibody
  • ferritin repressor protein (FRP) antibody
  • Aco-1 antibody
  • Aco1 antibody
  • Acon1 antibody
  • ACONS antibody
  • AI256519 antibody
  • EFE antibody
  • ETH1 antibody
  • IREB1 antibody
  • IREBP antibody
  • IREBP1 antibody
  • IRP1 antibody
  • LEACO1 antibody
  • pTOM13 antibody
  • Ratireb antibody
  • wu:fo75b03 antibody

Protein level used designations for ACO1

aconitase 1, soluble , cytoplasmic aconitate hydratase , iron regulatory protein 1 , aconitase 1-like , 1-Aminocyclopropane-1-carboxylic acid oxidase , ACC oxidase 1 , ethylene-forming enzyme , protein pTOM 13 , IRE-BP 1 , citrate hydro-lyase , cytoplasmic aconitase , iron-responsive element-binding protein 1 , IRE-binding protein 1 , Iron responsive element binding protein , aconitate hydratase, cytoplasmic , ferritin repressor protein , iron-responsive element binding protein 1 , IRP1 , aconitase

GENE ID SPECIES
465034 Pan troglodytes
568448 Danio rerio
100173767 Pongo abelii
705075 Macaca mulatta
100016997 Monodelphis domestica
100216202 Xenopus (Silurana) tropicalis
100227513 Taeniopygia guttata
100368089 Saccoglossus kowalevskii
100555878 Anolis carolinensis
100607117 Nomascus leucogenys
100628006 Sus scrofa
100634468 Amphimedon queenslandica
544052 Solanum lycopersicum
11428 Mus musculus
380269 Xenopus laevis
373916 Gallus gallus
48 Homo sapiens
481576 Canis lupus familiaris
512995 Bos taurus
50655 Rattus norvegicus
100067866 Equus caballus
100009154 Oryctolagus cuniculus
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