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Aconitase 1, Soluble Proteins (ACO1)

Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). Additionally we are shipping Aconitase 1 Antibodies (71) and Aconitase 1 Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ACO1 11428 P28271
ACO1 48 P21399
Rat ACO1 ACO1 50655 Q63270
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Top Aconitase 1 Proteins at antibodies-online.com

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag 10 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Baculovirus infected Insect Cells Human His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 3 to 4 Days
$364.64
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   1 μg Log in to see 6 to 11 Days
$142.86
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

ACO1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
,

Top referenced Aconitase 1 Proteins

  1. Human Aconitase 1 Protein expressed in Escherichia coli (E. coli) - ABIN667323 : Salahudeen, Thompson, Ruiz, Ma, Kinch, Li, Grishin, Bruick: An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis. in Science (New York, N.Y.) 2009 (PubMed)
    Show all 2 references for ABIN667323

More Proteins for Aconitase 1, Soluble (ACO1) Interaction Partners

Pig (Porcine) Aconitase 1, Soluble (ACO1) interaction partners

  1. Iron increases turnover of ACO1 in kidney cells, while increasing aconitase (show ACO2 Proteins) activity, suggesting that the apoprotein (show APOE Proteins) (aconitase (show ACO2 Proteins)-inactive) form is not exclusively responsible for turnover.

Mouse (Murine) Aconitase 1, Soluble (ACO1) interaction partners

  1. The Irp1-/- mice develop polycythemia and pulmonary hypertension, and suggesting that Irp1 plays an essential role in erythropoiesis and in the pulmonary and cardiovascular systems.

  2. IRP1 and IRP2 (show IREB2 Proteins) mutant mice rapidly succumb to systemic infection with Salmonella Typhimurium, a pathogenic bacterium that multiplies within macrophages, with increased bacterial burdens in liver and spleen.

  3. results uncover an unexpected protective role of IRP1 in pathological conditions associated with altered Fe-S metabolism

  4. Aco1 KD in fully differentiated 3T3-L1 adipocytes decreased lipogenic, Idh1, Adipoq, and Glut4 gene expression.

  5. impaired mitochondrial [Fe-S] cluster biogenesis in Mfrn1(gt/gt (show FABP6 Proteins)) cells results in elevated IRP1 RNA-binding that attenuates ALAS2 (show ALAS2 Proteins) mRNA translation and protoporphyrin accumulation

  6. Data indicate that JTR-009, a benzimidazole, operated by preventing iron-regulatory protein-1 (IRP1) from binding to the iron-responsive element (IRE) in APP (show APP Proteins) mRNA.

  7. Human ACO1 is a moonlighting protein that has both aco (show ACO2 Proteins)nitase enzyme activity as well as an mRNA binding function.

  8. Aco1 is a moonlighting protein that has aconitase (show ACO2 Proteins) activity as well as mRNA binding ability.

  9. IRP1 is the principal regulator of HIF2alpha (show EPAS1 Proteins) mRNA translation

  10. Irp1 deletion enhanced HIF2alpha (show EPAS1 Proteins) protein expression in kidneys of Irp1(-/-) mice.

Human Aconitase 1, Soluble (ACO1) interaction partners

  1. The SNP rs7874815 in the ACO1 gene was strongly associated with survival in pancreatic cancer.

  2. Our results confirm the observation that mitoNEET (show CISD1 Proteins) is important in transferring the iron sulfur clusters to the cytosolic aconitase in living cells and the His-87 ligand in mitoNEET (show CISD1 Proteins) plays important role in this process.

  3. Data show that IRP1 suppressed TfR1/DMT1 (+IRE) expression, limited the cellular iron content and decreased lactate dehydrogenase (LDH) release induced by hypoxia.

  4. These in vitro studies suggest that human GLRX3 (show GLRX3 Proteins) is important for cytosolic Fe-S protein (show CDSN Proteins) maturation.

  5. SIRT3 (show SIRT3 Proteins) overexpression decreases TfR1 (show TFRC Proteins) expression by inhibiting IRP1 and represses proliferation in pancreatic cancer cells.

  6. ACO1 gene expression was positively associated with adipogenic markers in subcutaneous and visceral adipose tissue.

  7. ACO1 genetic variation is associated with neuropathic pain and pain severity in HIV-infected patients on antiretroviral therapy

  8. MitoNEET (show CISD1 Proteins) governs a novel trafficking pathway to rebuild an Fe-S cluster into cytosolic aconitase/IRP1.

  9. Polymer-dependent translocation of IRP-1 in Cd(2 (show CD2 Proteins)+)-exposed cells may underlie effects of Cd(2 (show CD2 Proteins)+) on iron homeostasis.

  10. Data indicate that JTR-009, a benzimidazole, operated by preventing iron-regulatory protein-1 (IRP1) from binding to the iron-responsive element (IRE) in APP (show APP Proteins) mRNA.

Rabbit Aconitase 1, Soluble (ACO1) interaction partners

  1. Even though the base-specific RNA-binding residues are not part of the aconitase active site, their substitutions can affect the aconitase activity of holo-IRP1, positively or negatively.

Aconitase 1 (ACO1) Protein Profile

Protein Summary

Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.

Gene names and symbols associated with Aconitase 1, Soluble Proteins (ACO1)

  • aconitase 1, soluble (ACO1)
  • aconitase 1, soluble (aco1)
  • aconitase 1, soluble (LOC100227513)
  • 1-aminocyclopropane-1-carboxylate oxidase 1 (ACO1)
  • aconitase 1 (Aco1)
  • aconitase 1, soluble (Aco1)
  • ferritin repressor protein (FRP)
  • Aco-1 protein
  • Aco1 protein
  • Acon1 protein
  • ACONS protein
  • AI256519 protein
  • EFE protein
  • ETH1 protein
  • IREB1 protein
  • IREBP protein
  • IREBP1 protein
  • IRP1 protein
  • LEACO1 protein
  • pTOM13 protein
  • Ratireb protein
  • wu:fo75b03 protein

Protein level used designations for Aconitase 1, Soluble Proteins (ACO1)

aconitase 1, soluble , cytoplasmic aconitate hydratase , iron regulatory protein 1 , aconitase 1-like , 1-Aminocyclopropane-1-carboxylic acid oxidase , ACC oxidase 1 , ethylene-forming enzyme , protein pTOM 13 , IRE-BP 1 , citrate hydro-lyase , cytoplasmic aconitase , iron-responsive element-binding protein 1 , IRE-binding protein 1 , Iron responsive element binding protein , aconitate hydratase, cytoplasmic , ferritin repressor protein , iron-responsive element binding protein 1 , IRP1 , aconitase

GENE ID SPECIES
465034 Pan troglodytes
568448 Danio rerio
100173767 Pongo abelii
705075 Macaca mulatta
100016997 Monodelphis domestica
100216202 Xenopus (Silurana) tropicalis
100227513 Taeniopygia guttata
100368089 Saccoglossus kowalevskii
100555878 Anolis carolinensis
100607117 Nomascus leucogenys
100628006 Sus scrofa
100634468 Amphimedon queenslandica
544052 Solanum lycopersicum
11428 Mus musculus
380269 Xenopus laevis
373916 Gallus gallus
48 Homo sapiens
481576 Canis lupus familiaris
512995 Bos taurus
50655 Rattus norvegicus
100067866 Equus caballus
100009154 Oryctolagus cuniculus
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