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anti-Aconitase 2, Mitochondrial (ACO2) Antibodies

The protein encoded by ACO2 belongs to the aconitase/IPM isomerase family. Additionally we are shipping ACO2 Kits (34) and ACO2 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ACO2 50 Q99798
ACO2 11429 Q99KI0
ACO2 79250 Q9ER34
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Top anti-ACO2 Antibodies at antibodies-online.com

Showing 10 out of 97 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Caenorhabditis elegans Rabbit Un-conjugated WB WB Suggested Anti-ACO2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Human heart Rabbit Anti-ACO2 Antibody ,Paraffin Embedded Tissue: Human Pineal Tissue 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-ACO2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: 721_B cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-ACO2 Pab (ABIN388648) in mouse heart(left) and 293 (right) tissue lysates (35 µg/lane). ACO2(arrow) was detected using the purified polyclonal antibody (1:60 dilution). Perfused isolated rat heart whole tissue lysate was lysed with either A) 50 mM Tris-HCl, 150 mM NaCl, 1 mM EDTA, 1% NP-40, 0.1% SDS, 0.5% Na-deoxycholate, 1 mM Na3VO4, 20 mM NaF, 1 mM PMSF, 5 v/v % protease inhibitor cocktail or B) T-PER Tissue Protein Extraction Reagent [# 785101. Pierce], containing 1mM Na3VO4, 20 mM NaF, 5 v/v % protease inhibitor cocktail (Sigma). PVDF membrane was incubated in primary Ab [rabbit polyclonal antibody against ACO2 (Center) (ABIN388648). Solution: 1:1000 diluted in 5% NFM TBS-T 0,05 for overnight (15 hrs) at 4 °. Data courtesy of Boglarka Laczy M.D., Division of Cardiovascular Disease, Dept. of Medicine, University of Alabama at Birmingham. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of ACO2 (arrow) using rabbit polyclonal ACO2 Antibody (Center) (ABIN391809).293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the ACO2 gene (Lane 2) (Origene Technologies). Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with ACO2 antibody (Center) (ABIN391809), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Cow Goat Un-conjugated EIA, IHC (p), WB AP21267PU-N ACO2 Antibody staining of paraffin embedded Human Breast at 3.8 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. AP21267PU-N ACO2 Antibody staining of Human (A), Mouse (B) and Rat (C) Adipose lysates at 0.1 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Cow Goat Un-conjugated EIA, IF, IHC (p), WB AP23725PU-N ACO2 Antibody staining of paraffin embedded Human Breast at 3.8 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. AP23725PU-N ACO2 Antibody staining of Heart Liver lysate at 0.01 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with ACO2 antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Western blot analysis of ACO2 (arrow) using rabbit polyclonal ACO2 Antibody 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Goat Un-conjugated IHC, ELISA, WB (0.01µg/ml) staining of Heart lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details

ACO2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
, ,
,
, , , , ,
Mouse (Murine)
,

Rat (Rattus)
,

Top referenced anti-ACO2 Antibodies

  1. Human Polyclonal ACO2 Primary Antibody for EIA, WB - ABIN357262 : Geurts van Kessel, Westerveld, de Groot, Meera Khan, Hagemeijer: Regional localization of the genes coding for human ACO2, ARSA, and NAGA on chromosome 22. in Cytogenetics and cell genetics 1981 (PubMed)
    Show all 8 references for ABIN357262

  2. Human Polyclonal ACO2 Primary Antibody for IHC (p), WB - ABIN388648 : OConnell, Gannon, Doran, Ohlendieck: Proteomic profiling reveals a severely perturbed protein expression pattern in aged skeletal muscle. in International journal of molecular medicine 2007 (PubMed)
    Show all 4 references for ABIN388648

  3. Human Polyclonal ACO2 Primary Antibody for EIA, IHC (p) - ABIN359720 : Yu, Costello, Feng, Franklin: Characterization of the mitochondrial aconitase promoter and the identification of transcription factor binding. in The Prostate 2006 (PubMed)
    Show all 3 references for ABIN359720

  4. Chicken Polyclonal ACO2 Primary Antibody for WB - ABIN2786627 : Schauer, Freund, Prenni, Curthoys: Proteomic profiling and pathway analysis of the response of rat renal proximal convoluted tubules to metabolic acidosis. in American journal of physiology. Renal physiology 2013 (PubMed)
    Show all 3 references for ABIN2786627

  5. Cow (Bovine) Polyclonal ACO2 Primary Antibody for EIA, IF - ABIN615944 : Bota, Davies: Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism. in Nature cell biology 2002 (PubMed)

  6. Human Polyclonal ACO2 Primary Antibody for IHC (p), WB - ABIN391809 : Dey, Guha, Alam, Goyal, Bindu, Pal, Maity, Mitra, Bandyopadhyay: Malarial infection develops mitochondrial pathology and mitochondrial oxidative stress to promote hepatocyte apoptosis. in Free radical biology & medicine 2009 (PubMed)

  7. Caenorhabditis elegans (C. elegans) Polyclonal ACO2 Primary Antibody for WB - ABIN2786628 : Scheving, Wittig, Heide, Albuquerque, Steger, Brandt, Tegeder: Protein S-nitrosylation and denitrosylation in the mouse spinal cord upon injury of the sciatic nerve. in Journal of proteomics 2012 (PubMed)

More Antibodies against ACO2 Interaction Partners

Arabidopsis thaliana Aconitase 2, Mitochondrial (ACO2) interaction partners

  1. The identification of ACO1 (show ACO1 Antibodies), ACO2, and ACO3 in A. thaliana is reported, and it was demonstrated that, in plants, the cytosolic ACOs are not converted into iron regulatory proteins.

Human Aconitase 2, Mitochondrial (ACO2) interaction partners

  1. Results suggest that ACO2 activity is reduced in peripheral lymphocytes of subjects with Alzheimer's disease and mild cognitive impairment and correlates with antioxidant protection

  2. Our study shows that autosomal recessive ACO2 mutations can cause either isolated or syndromic optic neuropathy.

  3. immunofluorescence staining localized ACO2 to the human sperm mid-piece. By immunoblotting, we demonstrated that the level of ACO2 protein in asthenozoospermic samples was significantly decreased compared with that in normal fertile men

  4. Ogg1 (show OGG1 Antibodies) chaperoning of Aco-2 in preventing oxidant-mediated mtDNA damage and apoptosis may afford an innovative target for the molecular events underlying oxidant-induced toxicity.

  5. Hypoxia upregulates the gene expression of mitochondrial aconitase in prostate carcinoma cells

  6. Gastric cancer patients with lower ACO2 expression have a shorter survival time than those with higher ACO2 expression.

  7. Homozygosity mapping followed by whole-exome sequencing disclosed a Ser112Arg mutation in ACO2.

  8. these results suggest that p53 downregulation of mACON gene expression in human prostate carcinoma cells may not occur through the putative consensus p53 response elements found within the mACON promoter.

  9. Lon (show LONP1 Antibodies) protease selectively recognizes and degrades the oxidized, hydrophobic form of aconitase (show ACO1 Antibodies) after mild oxidative modification, but that severe oxidation results in aconitase (show ACO1 Antibodies) aggregation, which makes it a poor substrate for Lon (show LONP1 Antibodies).

  10. ACO2 is often deleted in colorectal cancer (show DCC Antibodies) but is unlikely to be the true target of the deletions

Mouse (Murine) Aconitase 2, Mitochondrial (ACO2) interaction partners

  1. Activation of mitochondrial aconitase is acetylation-dependent.

  2. Ogg1 (show OGG1 Antibodies) chaperoning of Aco-2 in preventing oxidant-mediated mtDNA damage and apoptosis may afford an innovative target for the molecular events underlying oxidant-induced toxicity.

  3. IRP-1 (show ACO1 Antibodies),-2 are indispensable for regulation of mammalian iron homeostasis at the post-implantation stage of murine embryonic development

  4. aconitase activity can be regulated by at least two mechanisms: oxidation/reduction and phosphorylation/dephosphorylation

Pig (Porcine) Aconitase 2, Mitochondrial (ACO2) interaction partners

  1. study examined the sites and mechanisms of aconitase inactivation by peroxynitrite (ONOO-), a strong oxidant and nitrating agent readily formed from superoxide anion and nitric oxide generated by mitochondria

ACO2 Antigen Profile

Protein Summary

The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification.

Gene names and symbols associated with ACO2

  • aconitase 2, mitochondrial (ACO2) antibody
  • aconitase 2, mitochondrial (aco2) antibody
  • aconitate hydratase, mitochondrial (Bm1_07420) antibody
  • aconitase, mitochondrial (aco2) antibody
  • mitochondrial aconitate hydratase (ach1) antibody
  • aconitase 2 (ACO2) antibody
  • aconitase 2, mitochondrial (LOC100352714) antibody
  • aconitase 2, mitochondrial (Aco2) antibody
  • Protein ACO-2 (aco-2) antibody
  • Aco-2 antibody
  • Aco3 antibody
  • aconitase 2 antibody
  • ACONM antibody
  • cb1017 antibody
  • D10Wsu183e antibody
  • DDBDRAFT_0206187 antibody
  • DDBDRAFT_0230168 antibody
  • DDB_0206187 antibody
  • DDB_0230168 antibody
  • F10M23.310 antibody
  • F10M23_310 antibody
  • ICRD antibody
  • wu:fa10e03 antibody
  • wu:fb69g04 antibody
  • wu:fc20c11 antibody

Protein level used designations for ACO2

aconitate hydratase, mitochondrial , mitochondrial aconitate hydratase , aconitase 2, mitochondrial , aconitate hydratase, mitochondrial-like , citrate hydro-lyase , mitochondrial aconitase (nuclear aco2 gene) , heart aconitase

GENE ID SPECIES
374009 Gallus gallus
444692 Xenopus laevis
6096411 Brugia malayi
8621690 Dictyostelium discoideum AX4
9617127 Volvox carteri f. nagariensis
100444223 Pongo abelii
496933 Xenopus (Silurana) tropicalis
707441 Macaca mulatta
828805 Arabidopsis thaliana
100352714 Oryctolagus cuniculus
100389367 Callithrix jacchus
100568244 Anolis carolinensis
100598337 Nomascus leucogenys
50 Homo sapiens
11429 Mus musculus
79250 Rattus norvegicus
396999 Sus scrofa
280976 Bos taurus
474487 Canis lupus familiaris
322670 Danio rerio
176121 Caenorhabditis elegans
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