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May be involved in podosome and invadosome formation (By similarity). Additionally we are shipping AFAP1L1 Antibodies (17) and many more products for this protein.
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data define a novel pathway that directs Lyn (show LYN Proteins)/Src (show SRC Proteins) family tyrosine kinase (show TXK Proteins) signals to sarcoma cell invadopodia through specific recruitment of Vav2 and Nck2 (show NCK2 Proteins) to phosphorylated AFAP1L1, to control cell migration and invasion
AFAP1L1 plays a role in the progression of colorectal cancer by modulating cell shape and motility and by inhibiting anoikis, presumably through interactions with vinculin (show VCL Proteins)-including protein complexes.
Findings indicate a role for transcription factor Sp3 in sarcomas as a driver for expression of the metastasis-related gene AFAP1L1 (actin filament-associated protein 1-like 1).
AFAP1L1 has a role in the progression of spindle cell sarcomas and is a prognostic biomarker.
Data suggest that AFAP1L1 may forge unique protein interactions in which AFAP1 (show AFAP1 Proteins) is less efficient, and these interactions may allow AFAP1L1 to affect invadosome formation.
May be involved in podosome and invadosome formation (By similarity).
actin filament associated protein 1-like 1
, AFAP1-like protein 1
, actin filament-associated protein 1-like 1
, actin filament-associated protein, 110 kDa