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anti-Actinin, alpha 1 (ACTN1) Antibodies

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Additionally we are shipping ACTN1 Kits (6) and ACTN1 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ACTN1 87 P12814
ACTN1 109711 Q7TPR4
ACTN1 81634 Q9Z1P2
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Top anti-ACTN1 Antibodies at antibodies-online.com

Showing 10 out of 77 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-ACTN1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: 293T cell lysate Sample Type: 1.-4. rACTN1-GFP + HEK293 (50ug)Primary Dilution: 1:1000-1:2000Secondary Antibody: HRP conjugated goat anti-rabbitSecondary Dilution: 1:20,000Image Submitted By: Magdalena KalinowskaAlbert Einstein College of Medicine 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of ACTN1 Antibody (N-term) (ABIN652451) in MDA-MB231 cell line lysates (35 µg/lane). ACTN1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human breast carcinoma with ACTN1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated WB Western Blot analysis of ACTN1 expression in transfected 293T cell line by ACTN1 monoclonal antibody (M01), clone 3F1. Lane 1: ACTN1 transfected lysate(103.1 KDa). Lane 2: Non-transfected lysate. 50 μg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated IF, IHC, WB Anti-ACTN1 mouse monoclonal antibody (ABIN2452359) immunofluorescent staining of HeLa cells transiently transfected by pCMV6-ENTRY ACTN1 (RC204924) Immunofluorescent staining of HeLa cells using anti-ACTN1 mouse monoclonal antibody (ABIN2452359). 100 μL Log in to see 2 to 3 Days
$482.90
Details
Human Mouse Un-conjugated IF, IHC (p), IP, WB   0.1 mg Log in to see 6 to 8 Days
$313.50
Details
Chicken Mouse Un-conjugated EIA, IHC (fro), WB   0.1 mg Log in to see 6 to 8 Days
$610.50
Details
Human Mouse Un-conjugated ELISA, WB Western Blot analysis of ACTN1 expression in transfected 293T cell line by ACTN1 monoclonal antibody (M01), clone 3F1.Lane 1: ACTN1 transfected lysate(103.1 KDa).Lane 2: Non-transfected lysate. Western Blot detection against Immunogen (36.41 KDa) . 100 μg Log in to see 9 Days
$430.00
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded SW480 xenograft , using Alpha-actinin 1, antibody at 1:100 dilution. WB Image Sample (30 ug of whole cell lysate) A:NIH-3T3 7.5% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 2 to 3 Days
$358.60
Details

ACTN1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-ACTN1 Antibodies

  1. Human Monoclonal ACTN1 Primary Antibody for WB - ABIN2838573 : Jugessur, Shi, Gjessing, Lie, Wilcox, Weinberg, Christensen, Boyles, Daack-Hirsch, Nguyen, Christiansen, Lidral, Murray: Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. in PLoS ONE 2010 (PubMed)
    Show all 5 references for ABIN2838573

  2. Chicken Monoclonal ACTN1 Primary Antibody for EIA, IHC (fro) - ABIN1105321 : Dubowitz: Chaos in the classification of SMA: a possible resolution. in Neuromuscular disorders : NMD 1995 (PubMed)
    Show all 2 references for ABIN1105321

  3. Human Monoclonal ACTN1 Primary Antibody for ELISA, WB - ABIN559761 : Quick, Skalli: Alpha-actinin 1 and alpha-actinin 4: contrasting roles in the survival, motility, and RhoA signaling of astrocytoma cells. in Experimental cell research 2010 (PubMed)
    Show all 2 references for ABIN559761

  4. Human Monoclonal ACTN1 Primary Antibody for IF, IHC (p) - ABIN1105322 : Youssoufian, McAfee, Kwiatkowski: Cloning and chromosomal localization of the human cytoskeletal alpha-actinin gene reveals linkage to the beta-spectrin gene. in American journal of human genetics 1990 (PubMed)

  5. Human Monoclonal ACTN1 Primary Antibody for IF, IHC - ABIN2452359 : Shuliang, Lei, Guangwu, Changjie: Involvement of ubiquitin-conjugating enzyme E2C in proliferation and invasion of prostate carcinoma cells. in Oncology research 2014 (PubMed)

  6. Chicken Polyclonal ACTN1 Primary Antibody for IHC, WB - ABIN2787669 : Li, Dai, Shen, Wu, Long, Chen, Hussain, Wang, Chen: Direct binding of alpha-actinin enhances TRPP3 channel activity. in Journal of neurochemistry 2007 (PubMed)

  7. Human Polyclonal ACTN1 Primary Antibody for EIA, WB - ABIN452717 : Zhang, Lin, Neel, Haimovich: Phosphorylated alpha-actinin and protein-tyrosine phosphatase 1B coregulate the disassembly of the focal adhesion kinase x Src complex and promote cell migration. in The Journal of biological chemistry 2006 (PubMed)

More Antibodies against ACTN1 Interaction Partners

Human Actinin, alpha 1 (ACTN1) interaction partners

  1. Drp1 is in dynamic equilibrium on mitochondria in a fission-independent manner, and that fission factors such as actin filaments target productive oligomerization to fission sites.

  2. Host cortactin, PKD1 and actin are recruited by Trypanosoma cruzi extracellular amastigotes based on experiments in fixed and live cells by time lapse confocal microscopy.

  3. The authors show that the microtubule binding protein EB1 (end-binding protein 1), a key regulator of microtubule dynamics, can bind directly to filamentous actin (F-actin) F-actin.

  4. Several dominantly inherited congenital macrothrombocytopenia-associated mutations that are located within the actinin-1 actin-binding domain cause increased binding of actinin-1 to actin filaments and enhance filament bundling in vitro.

  5. Data indicate that alpha-actinin (110 kDa) autoantibody was characterized as a major target in lupus nephritis (LN) patients positive for Anti-membrane autoantibodies (MbA).

  6. ACTN1 determines the motility of keratinocytes by regulating the organization of the actin cytoskeleton, focal adhesion, and hemidesmosome proteins complexes, thereby modulating cell speed, lamellipodial dynamics, and directed migration

  7. ArgBP2 interaction with alpha-actinin and actin stress fibers inhibits cell migration

  8. ACTN1-related thrombocytopenia is characterized by mild course with platelet macrocytosis and low risk for bleeding.

  9. A missense mutation in the alpha-actinin 1 gene (ACTN1) is the cause of autosomal dominant macrothrombocytopenia in a large French family.

  10. The C-terminal polybasic region of CYTH2 (show CYTH2 Antibodies) participates in interacting directly with the EFh2 domain of ACTN1.

Mouse (Murine) Actinin, alpha 1 (ACTN1) interaction partners

  1. Furthermore, this F-actin mesh network attached to the synaptic ribbons directly influences the efficiency of otoferlin (show OTOF Antibodies)-dependent exocytosis and its sensitivity to intracellular hydrostatic pressure.

  2. These findings evidence alpha-actinin involvement in sarcomeric development, suggesting for this protein an important role in stabilizing the muscle contractile apparatus.

  3. The C-terminal polybasic region of CYTH2 (show CYTH2 Antibodies) participates in interacting directly with the EFh2 domain of ACTN1.

  4. Actn1 differential methylation occurs in diverse mouse tissues. Authors have found no indication of an imprinted effect on gene expression of Actn1 in mice.

  5. alpha-actinin has a role in adhesion maturation through integrin-dependent force transmission to the extracellular matrix

  6. Alpha-actinin interaction with syndecan-4 (show SDC4 Antibodies) has a role in stabilising cell-matrix adhesion.

  7. the SRF-cofilin-actin signaling axis modulates neuronal mitochondrial function

  8. vinculin (show VCL Antibodies) engagement of adhesion receptors first activates talin or alpha-actinin, by provoking structural changes that allow their vinculin (show VCL Antibodies) binding sites to swing out, which are then sufficient to bind to and activate vinculin (show VCL Antibodies)

  9. EFA6A may form a protein complex with alpha-actinin and activate ARF6 in close proximity of the actin cytoskeleton and membrane proteins in the dendritic spines

  10. there is an alpha-actinin-1-dependent mGlu(5b) receptor association with the actin cytoskeleton modulating receptor cell surface expression and functioning

ACTN1 Antigen Profile

Protein Summary

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with ACTN1

  • actinin, alpha 1 (ACTN1) antibody
  • actinin, alpha 1 (actn1) antibody
  • actinin, alpha 1 (Actn1) antibody
  • 3110023F10Rik antibody
  • actinin antibody
  • ACTN1 antibody
  • Actn1a antibody
  • BDPLT15 antibody

Protein level used designations for ACTN1

actinin, alpha 1 , alpha actinin , Alpha-actinin-1 , alpha-actinin-1 , F-actin cross-linking protein , actinin 1 smooth muscle , alpha-actinin cytoskeletal isoform , non-muscle alpha-actinin-1 , alpha actinin 1a , non-muscle alpha-actinin 1 , alpha-actinin 1

GENE ID SPECIES
452993 Pan troglodytes
780123 Xenopus (Silurana) tropicalis
100380299 Salmo salar
100513412 Sus scrofa
100596303 Nomascus leucogenys
87 Homo sapiens
373918 Gallus gallus
109711 Mus musculus
81634 Rattus norvegicus
560400 Danio rerio
399422 Xenopus laevis
480369 Canis lupus familiaris
524770 Bos taurus
100341378 Oryctolagus cuniculus
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