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Actinin, alpha 2 Proteins (ACTN2)

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Additionally we are shipping ACTN2 Antibodies (82) and ACTN2 Kits (31) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ACTN2 11472 Q9JI91
Rat ACTN2 ACTN2 291245  
ACTN2 88 P35609
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Top ACTN2 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 13 Days
$668.80
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$841.86
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

ACTN2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,

More Proteins for Actinin, alpha 2 (ACTN2) Interaction Partners

Mouse (Murine) Actinin, alpha 2 (ACTN2) interaction partners

  1. Data suggest that kindlin-2 (Kind2/Fermt2 (show FERMT2 Proteins)) interacts with actin alpha 2 (Actn2) and integrin beta 1 (Itgb1 (show ITGB1 Proteins)) and co-localizes to cardiac sarcomere at Z-disc; knockdown of Kind2 (show FERMT2 Proteins) leads to dissociation of Actn2 and Itgb1 (show ITGB1 Proteins).

  2. Data show that alpha-Actinin 2 and CaMKIIalph (show NEXN Proteins)a exist in complex with GluN2B in forebrain.

  3. Data demonstrated that the Z-disk proteins, ZASP (show LDB3 Proteins), titin (show TTN Proteins) and vinculin (show VCL Proteins) preferentially bind to alpha-actinin-2. Thus, the loss of alpha-actinin-3 (show ACTN3 Proteins) changes the overall protein composition of fast fiber Z-disks and alters their elastic properties.

  4. alpha-Actinin (show ACTN1 Proteins), rapsyn (show RAPSN Proteins), and surface AChR form a ternary complex.

  5. BPAG1 (show DST Proteins)-b was detectable in vitro and in vivo as a high molecular mass protein in striated (show NSDHL Proteins) and heart muscle cells, co-localizing with alpha-actinin-2 and partially with the cytolinker plectin as well as with the intermediate filament protein desmin (show DES Proteins).

  6. demonstrate that proper membrane localization of a small-conductance Ca(2 (show CA2 Proteins)+)-activated K(+) channel (show KCNC4 Proteins) (SK2 (show PAPSS2 Proteins) or K(Ca)2.2) is dependent on its interacting protein, alpha-actinin2, a major F-actin crosslinking protein (show MACF1 Proteins).

Human Actinin, alpha 2 (ACTN2) interaction partners

  1. study strengthens the hypothesis that ACTN2 influences caries risk.

  2. The novel heterozygous missense sequence variant ACTN2 cosegregated with a complex cardiomyopathic trait, characterized by the interplay of midapical, nonobstructive HCM, early onset of AF and AV block, as well as regional LV noncompaction.

  3. Clinical evaluation of an Australian family revealed diverse cardiac pathologies in four affected members and genetic testing of the exome identified a pathogenic ACTN2 heterozygous variant (Ala119Thr) that co-segregated with disease.

  4. Study reports a complete high-resolution structure of the 200 kDa alpha-actinin-2 dimer from striated (show NSDHL Proteins) muscle and explore its functional implications on the biochemical and cellular level.

  5. This study generated the genomic sequences of K88-positive and F18 (show MAMLD1 Proteins)-positive porcine enteroteoxigenic E. coli (ETEC) strains and examined the phylogenetic distribution of clinical porcine ETEC strains and their plasmid-associated genetic content.

  6. Findigs show that the F-actin-binding protein alpha-actinin-2 targets CaMKIIalpha to F-actin in cells by binding to the CaMKII (show CAMK2G Proteins) regulatory domain.

  7. data provide functional evidence that the primary sequences of alpha-actinin-2 and alpha-actinin-3 (show ACTN3 Proteins) evolved differences to optimize their functions

  8. This is the first genome-wide linkage analysis that shows mutations in ACTN2 cause HCM

  9. BPAG1 (show DST Proteins)-b was detectable in vitro and in vivo as a high molecular mass protein in striated (show NSDHL Proteins) and heart muscle cells, co-localizing with alpha-actinin-2 and partially with the cytolinker plectin as well as with the intermediate filament protein desmin (show DES Proteins).

  10. Spectrin-like repeats from dystrophin (show DMD Proteins) and alpha-actinin-2 are not functionally interchangeable.

Zebrafish Actinin, alpha 2 (ACTN2) interaction partners

ACTN2 Protein Profile

Protein Summary

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles.

Gene names and symbols associated with Actinin, alpha 2 Proteins (ACTN2)

  • actinin, alpha 2 (actn2)
  • actinin, alpha 2 (ACTN2)
  • actinin alpha 2 (Actn2)
  • actinin, alpha 2 (Actn2)
  • 1110008F24Rik protein
  • ACTN2 protein
  • CMD1AA protein
  • MGC89234 protein
  • wu:fd44c03 protein
  • zgc:123223 protein

Protein level used designations for Actinin, alpha 2 Proteins (ACTN2)

actinin, alpha 2 , alpha 2 actinin , alpha-actinin-2-like , F-actin cross-linking protein , alpha-actinin skeletal muscle , alpha-actinin-2

GENE ID SPECIES
448602 Xenopus (Silurana) tropicalis
469156 Pan troglodytes
100033870 Equus caballus
100481134 Ailuropoda melanoleuca
11472 Mus musculus
291245 Rattus norvegicus
88 Homo sapiens
396263 Gallus gallus
479191 Canis lupus familiaris
100157406 Sus scrofa
536607 Bos taurus
641575 Danio rerio
432169 Xenopus laevis
100350274 Oryctolagus cuniculus
100712846 Cavia porcellus
101116372 Ovis aries
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