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Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Additionally we are shipping alpha Actinin 4 Antibodies (91) and alpha Actinin 4 Kits (15) and many more products for this protein.
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Human alpha Actinin 4 Protein expressed in Wheat germ - ABIN1305772
Karlsson, Turkina, Yakymenko, Magnusson, Vikström: The Pseudomonas aeruginosa N-acylhomoserine lactone quorum sensing molecules target IQGAP1 and modulate epithelial cell migration. in PLoS pathogens 2012
ACTN4 is a transcriptional coactivator of NF-kappaB (show NFKB1 Proteins).
UCHL1 (show UCHL1 Proteins) upregulation in ACTN4-associated FSGS.
sLZIP negatively regulates skeletal muscle differentiation via interaction with ACTN4.
the C-terminal tail of alpha-actinin-4 is essential for its function in cell migration and adhesion to substratum.
Dexamethasone mey protect actin cytoskeleton stabilization from adriamycin-induced podocyte injury via alpha-actinin-4.
anti-dsDNA Fab (show FANCB Proteins) may enhance F-actin formation by the proprietary modification of alpha-actinin-4
Together, these results indicate that alpha-actinin (show ACTN1 Proteins) and the actin cytoskeleton are important components of the cisternal organelle that are probably required to stabilize the AIS (show AR Proteins).
Results suggest that ACTN4 is essential for maintaining normal spreading, motility, cellular and nuclear cross-sectional area, and contractility of lung fibroblasts by maintaining the balance between transcellular contractility and cell-adhesion.
newly developed mouse model of ACTN4-associated FSGS suggests a cause-and-effect relationship between actin cytoskeleton dysregulation by mutant alpha-actinin-4 and the deterioration of the nephrin (show NPHS1 Proteins)-supported slit diaphragm complex.
nonsarcomeric alpha-actinin-4 is involved in the regulation of cell movement
This study identified alpha-actinin-4 as a novel NHERF1 (show SLC9A3R1 Proteins) interaction partner and provided new insights into the regulatory mechanism of the actin cytoskeleton by NHERF1 (show SLC9A3R1 Proteins).
Selective regulation of NF-kappaB (show NFKB1 Proteins) gene targets may indicate involvement of ACTN4 in determining the specificity of cell response to NF-kappaB (show NFKB1 Proteins) activation in cells of different types. (Review)
ZYX (show ZYX Proteins) defective binding to ACTN4, which occupies focal adhesions instead of ACTN1 (show ACTN1 Proteins), induces the formation of immature focal adhesions, resulting in the enhancement of cell motility and invasion.
The contribution of ACTN4 to the process of lung cancer metastasis to the brain could be mainly through regulation of actin cytoskeleton reorganization, cell motility, and focal adhesion.
SLK (show FYN Proteins) interacts with Tpr and alpha-actinin-4 in cells, and these protein-protein interactions may control the subcellular localization and the biological activity of SLK (show FYN Proteins).
key regulator of endothelial cell stiffness and of ICAM-1 (show ICAM1 Proteins)-mediated neutrophil transmigration
Knockdown of ACTN4 protein inhibited cell invasion and migration. These results suggest that ACTN4 is associated with lung cancer cell motility.
alpha-actinin-4 is a novel group 1 mGluR (show GRM8 Proteins)-interacting partner that orchestrates spine dynamics and morphogenesis in neurons.
Using fluorescence recovery after photobleaching, we show that an ACTN4 mutation that causes human kidney disease roughly triples the wild-type binding affinity of ACTN4 to F-actin in cells, increasing the dissociation time from 29 +/- 13 to 86 +/- 29 s.
Estrogen promotes the invasion of ovarian cancer cells via activation of the PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) pathway, downregulation of Ecadherin and upregulation of alphaactinin4.
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.
actinin, alpha 4
, F-actin cross-linking protein
, non-muscle alpha-actinin 4
, alpha actinin 4
, actinin alpha4 isoform
, focal segmental glomerulosclerosis 1