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ASCC1 encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. Additionally we are shipping ASCC1 Antibodies (31) and ASCC1 Kits (12) and many more products for this protein.
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ASCC1 inhibits NF-kappaB (show NFKB1 Proteins) activation and a truncated and inactive variant of ASCC1 is associated with a more severe disease, which could have clinical value for assessing the progression and prognosis of Rheumatoid Arthritis.
Three major genes, MSR1 (show MSR1 Proteins), ASCC1, and CTHRC1 (show CTHRC1 Proteins) were associated with Barrett esophagus/esophageal adenocarcinoma
Gastrin (show GAST Proteins) activates paracrine networks leading to induction of PAI-2 (show SERPINB2 Proteins) via MAZ (show MAZ Proteins) and ASC-1 (show RPL3 Proteins).
homozygous and compound-heterozygous nonsense and frameshift TRIP4 (show TRIP4 Proteins) and ASCC1 mutations that cosegregated with the Prenatal Spinal Muscular Atrophy and Congenital Bone Fracture phenotype
This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.
activating signal cointegrator 1 complex subunit 1
, ASC-1 complex subunit P50
, trip4 complex subunit p50
, ASC-1 complex subunit p50