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ATF3 encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. Additionally we are shipping ATF3 Antibodies (120) and ATF3 Kits (31) and many more products for this protein.
Showing 7 out of 9 products:
Human ATF3 Protein expressed in Wheat germ - ABIN1345929
Wang, Brennan, Gutierrez, Wang, Wang, Yang: SUMOylation of ATF3 alters its transcriptional activity on regulation of TP53 gene. in Journal of cellular biochemistry 2013
Show all 3 references for ABIN1345929
Human ATF3 Protein expressed in Escherichia coli (E. coli) - ABIN667497
Chen, Liang, Whelan, Hai: ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms. in The Journal of biological chemistry 1994
Show all 2 references for ABIN667497
Data show that Atf3 was detected in retinal ganglion cell axons in both the nerve fiber layer and the optic nerve on the injured side.
Data show that ATF3 may be an important mediator of optic nerve regeneration-promoting gene expression in fish, a role which merits further investigation.
CARMA1 (show CARD11 Proteins)- and MyD88 (show MYD88 Proteins)-dependent activation of Jun (show JUN Proteins)/ATF-type AP-1 (show FOSB Proteins) complexes is a hallmark of ABC (show ABCB6 Proteins) diffuse large B-cell lymphomas.
Activating transcription factor 3 represses inflammatory responses by binding to the p65 (show GORASP1 Proteins) subunit of NF-kappaB (show NFKB1 Proteins)
TGRL lipolysis products induce stress protein ATF3 via the TGF-beta (show TGFB1 Proteins) receptor pathway, resulting in induction of apoptosis in aortic endothelial cells
ATF3 regulates canonical TGFbeta and Smad signaling and fibroblast (show TGFB1 Proteins)activation in systemic sclerosis.
ATF3 overexpression leads to an increase of collective cell invasion phenotype in Colorectal Cancer.
Data suggest that after the expression of activating transcription factor 3 (ATF3) and microRNA miR (show MLXIP Proteins)-30c-2-3p elicited by lysophosphatidic acid, miR (show MLXIP Proteins)-30c-2-3p negatively regulates the expression of ATF3 through post-transcriptional silencing.
Taken together, these results suggest that ATF3 promotes the progression of human gliomas
DNA damage-triggered ATF3 controlled p53 (show TP53 Proteins) accumulation and generation of double-strand breaks may serve as a switch between DNA damage and cell death following TOP2A (show TOP2A Proteins) inhibitor treatment.
The stress-responsive gene ATF3 regulates the histone acetyltransferase Tip60 (show KAT5 Proteins) stability by promoting USP7 (show USP7 Proteins)-mediated deubiquitination of Tip60 (show KAT5 Proteins).
ATF3 is inactive in healthy hepatic cells and activated following hepatitis C virus infection.
Activating transcription factor 3 represses inflammatory responses by binding to the p65 (show NFkBP65 Proteins) subunit of NF-kappaB (show NFKB1 Proteins)
Knockout of the ATF3 gene reduced the stimulatory effect of TGFbeta (show TGFB1 Proteins) on fibroblasts by interfering with canonical Smad (show SMAD1 Proteins) signalling and protected the mice from experimental fibrosis in two different models.
ATF3 is a key regulator in cardiac hypertrophy through a cross-talk between cardiomyocytes and macrophages.
Data show that activating transcription factor 3 (ATF3) acted as a transcriptional repressor and regulated interferon-beta (IFN-beta (show IFNB1 Proteins)) via direct binding to a regulatory site distal to the Ifnb1 (show IFNB1 Proteins) promoter.
ATF3 binds to carboxyl-terminal modulator protein (show THEM4 Proteins) and suppresses its transcription following brain ischemia.
Involvement of ATF3 in the negative regulation of iNOS (show NOS2 Proteins) expression and NO production in activated macrophages
ATF3 suppresses fibrosis early but not late during infarct-induced heart failure. Although ATF3 deficiency was associated with more fibrosis, this did not occur at the expense of survival, which was higher in the ATF3-null mice.
these results demonstrate that during acute inflammation Atf3 negatively regulates Ptgs2 (show PTGS2 Proteins)
results thus link ATF3 to the AKT signaling, and suggest that ATF3 is a tumor suppressor for the major subset of prostate cancers harboring dysfunctional Pten
ATF3 confers protection to lung injury by preventing inflammatory cell recruitment and barrier disruption in a cell-specific manner, ATF3 deletion releases Nrf2 (show NFE2L2 Proteins) from ATF3-mediated transcriptional inhibition; however, absence of ATF3 results in Nrf2 (show NFE2L2 Proteins) proteasomal degradation.
ATF3 appears to affect gonadotropin-stimulated progesterone secretion at a step or steps downstream of PKA signaling and before cholesterol conversion to progesterone.
ATF3 induction by acute hypoxia is mediated by nitric oxide and the JNK (show MAPK8 Proteins) pathway in endothelial cells
Data indicate increasing expression for CREB (show CREB1 Proteins), ATF1 (show AFT1 Proteins), and ATF3 during gastrulation.
chromosome mapping of UCK2 (show UCK2 Proteins), ATF3 and RGS18 (show RGS18 Proteins) by radiation hybrid mapping. (UCK2 (show UCK2 Proteins) AND ATF3 AND RGS18 (show RGS18 Proteins))
This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes.
cyclic AMP-dependent transcription factor ATF-3
, activating transcription factor 3
, cAMP-dependent transcription factor ATF-3
, transcription factor LRG-21
, liver regeneration factor 1