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ATF4 encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. Additionally we are shipping ATF4 Kits (32) and ATF4 Proteins (16) and many more products for this protein.
Showing 10 out of 270 products:
Human Monoclonal ATF4 Primary Antibody for IF, WB - ABIN394112
Liew, Bochenski, Kawamori, Hu, Leech, Wanic, Malecki, Warram, Qi, Krolewski, Kulkarni: The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells. in The Journal of clinical investigation 2010
Show all 5 references for ABIN394112
Human Polyclonal ATF4 Primary Antibody for EIA, WB - ABIN950550
Dey, Baird, Zhou, Palam, Spandau, Wek: Both transcriptional regulation and translational control of ATF4 are central to the integrated stress response. in The Journal of biological chemistry 2010
Show all 5 references for ABIN950550
Human Polyclonal ATF4 Primary Antibody for WB - ABIN656176
Frank, Ge, Xie, Zhou, Tsai: Control of activating transcription factor 4 (ATF4) persistence by multisite phosphorylation impacts cell cycle progression and neurogenesis. in The Journal of biological chemistry 2010
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Mouse (Murine) Polyclonal ATF4 Primary Antibody for IHC, WB - ABIN2779918
Smith, Schmechel, Raghavan, Abelson, Reilly, Katze, Kaufman, Bohjanen, Schiff: Reovirus induces and benefits from an integrated cellular stress response. in Journal of virology 2006
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Human Polyclonal ATF4 Primary Antibody for EIA, WB - ABIN358807
Gombart, Grewal, Koeffler: ATF4 differentially regulates transcriptional activation of myeloid-specific genes by C/EBPepsilon and C/EBPalpha. in Journal of leukocyte biology 2007
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Human Polyclonal ATF4 Primary Antibody for EIA, WB - ABIN374137
Tsujimoto, Nyunoya, Morita, Sato, Shimotohno: Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I. in Journal of virology 1991
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Cow (Bovine) Polyclonal ATF4 Primary Antibody for WB - ABIN2780378
Lassot, Estrabaud, Emiliani, Benkirane, Benarous, Margottin-Goguet: p300 modulates ATF4 stability and transcriptional activity independently of its acetyltransferase domain. in The Journal of biological chemistry 2005
Human Polyclonal ATF4 Primary Antibody for WB - ABIN390250
Marchand, Tomkiewicz, Magne, Barouki, Garlatti: Endoplasmic reticulum stress induction of insulin-like growth factor-binding protein-1 involves ATF4. in The Journal of biological chemistry 2006
Human Polyclonal ATF4 Primary Antibody for WB - ABIN2792651
Zhou, Palam, Jiang, Narasimhan, Staschke, Wek: Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions. in The Journal of biological chemistry 2008
Over-expression of atf4 in embryos interferes with neurogenesis and eye formation.
Unlike other CREB2 (ATF4) proteins, the ATF4 isolated from the gonads of Xenopus embryos contains a consensus phosphorylation site for protein kinase A (PKA).
ATF4 and ATF6beta (show ATF6B Antibodies) act synergistically in the negative regulation of placental growth factor (show PGF Antibodies) mRNA expression
Authors observed that a slow rate of ATF4-translation and late re-initiation of general translation coincided with cells which were resistant to ER stress-induced cell death.
a reduction of cell death was associated with decreased levels of ATF4 in a rhabdomyosarcoma cell line
Combined administration inhibited the cells most potently and time-dependently, decreased the expression of HO-1 (show HMOX1 Antibodies), and significantly increased the expression of ATF4, CHOP (show DDIT3 Antibodies), and Ire-1 (show ERN1 Antibodies) proteins expression levels
Global profiling in human mesenchymal stem cells and a novel cell-free assay reveals that ATF4 requires C/EBPbeta (show CEBPB Antibodies) for genomic binding at a motif distinct from that bound by the C/EBPbeta (show CEBPB Antibodies) homodimer.
This study outlines the mechanism of NIR (show NOC2L Antibodies) laser phototoxicity and the utility of monitoring surface temperature and ATF4 expression as potential biomarkers to develop safe and effective clinical applications.
Up-regulation of ATF4 is associated with Pancreatic Neuroendocrine Tumors.
The ATF4/p75NTR (show NGFR Antibodies)/IL-8 (show IL8 Antibodies) signal pathway may have an important role in EndoMT induced by SFO.
ATF4 is a potential biomarker for esophageal squamous cell carcinoma (ESCC) prognosis and its dysregulation may play a key role in the regulation of invasion and metastasis in ESCC.
Upon loss of attachment in tumor cells, ATF4 activated a program of cytoprotective autophagy and antioxidant responses, including induced expression of heme oxygenase 1 (HO-1 (show HMOX1 Antibodies)). Increased levels of HO-1 (show HMOX1 Antibodies) ameliorated oxidative stress and cell death.
TFEB (show TFEB Antibodies)-regulated signaling pathway for osteoblast differentiation is involved in ATF4/CHOP (show DDIT3 Antibodies)-dependent signaling pathway.
These findings identify C/EBPgamma (show CEBPG Antibodies) as a novel antioxidant regulator and an obligatory ATF4 partner that controls redox homeostasis in normal and cancerous cells.
Gcn2 (show EIF2AK4 Antibodies) & Atf4 are involved in L-proline metabolism regulation in embryonic stem cells.
ATF4 plays a pivotal role in functional expansion and repopulating efficiency of HSCs in developing FL
results identify ursolic acid and tomatidine as potential agents and/or lead compounds for reducing ATF4 activity, weakness, and atrophy in aged skeletal muscle
The CARE-LUC mouse model represents an innovative tool to investigate the eIF2alpha (show EIF2A Antibodies)-ATF4 axis and to develop drugs targeting this important pathway in the remediation of related pathologies.
exogenous overexpression of ATF4 in breast cancer cells may facilitate the recruitment of macrophages into tumor tissues and promote tumor angiogenesis and tumor growth indirectly.
We conclude that ATF4 is a key regulator of the physiological state necessary for neuronal plasticity and memory.
Elevation of ATF4, at least in liver, thus seems to be a shared feature of diets, drugs, genes, and developmental alterations that extend maximum lifespan in mice.
expression levels of porcine ATF4 gene were up-regulated 60 days and 120 days after birth in both breeds and the expression level in Meishan pigs was obviously higher than that in Large White pigs
Tissue transcription analysis revealed that both porcine CREB2 (show ATF2 Antibodies) and CREB3 (show CREB3 Antibodies) mRNA were ubiquitously detected in all examined tissues.
This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication.
cyclic AMP-dependent transcription factor ATF-4
, activating transcription factor 4 (tax-responsive enhancer element B67)
, cAMP-dependent transcription factor ATF-4
, activating transcription factor 4C
, activating transcription factor 4
, DNA-binding protein TAXREB67
, cAMP response element-binding protein 2
, cAMP-responsive element-binding protein 2
, cyclic AMP-responsive element-binding protein 2
, tax-responsive enhancer element B67
, tax-responsive enhancer element-binding protein 67
, c/EBP-related ATF
, tax-responsive enhancer element-binding protein 67 homolog
, taxREB67 homolog
, activating transcription factor ATF-4