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ATF4 encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. Additionally we are shipping ATF4 Proteins (16) and ATF4 Kits (12) and many more products for this protein.
Showing 10 out of 282 products:
Human Polyclonal ATF4 Primary Antibody for EIA, WB - ABIN950550
Dey, Baird, Zhou, Palam, Spandau, Wek: Both transcriptional regulation and translational control of ATF4 are central to the integrated stress response. in The Journal of biological chemistry 2010
Show all 5 references for ABIN950550
Human Polyclonal ATF4 Primary Antibody for WB - ABIN656176
Frank, Ge, Xie, Zhou, Tsai: Control of activating transcription factor 4 (ATF4) persistence by multisite phosphorylation impacts cell cycle progression and neurogenesis. in The Journal of biological chemistry 2010
Show all 5 references for ABIN656176
Human Polyclonal ATF4 Primary Antibody for EIA, WB - ABIN4620546
Gombart, Grewal, Koeffler: ATF4 differentially regulates transcriptional activation of myeloid-specific genes by C/EBPepsilon and C/EBPalpha. in Journal of leukocyte biology 2007
Show all 4 references for ABIN4620546
Mouse (Murine) Polyclonal ATF4 Primary Antibody for IHC, WB - ABIN2779918
Smith, Schmechel, Raghavan, Abelson, Reilly, Katze, Kaufman, Bohjanen, Schiff: Reovirus induces and benefits from an integrated cellular stress response. in Journal of virology 2006
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Human Polyclonal ATF4 Primary Antibody for ELISA, WB - ABIN257681
Tsujimoto, Nyunoya, Morita, Sato, Shimotohno: Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I. in Journal of virology 1991
Show all 2 references for ABIN257681
Human Polyclonal ATF4 Primary Antibody for EIA, WB - ABIN374137
Gavilán, Pintado, Gavilán, Jiménez, Ríos, Vitorica, Castaño, Ruano: Dysfunction of the unfolded protein response increases neurodegeneration in aged rat hippocampus following proteasome inhibition. in Aging cell 2009
Show all 2 references for ABIN374137
Human Polyclonal ATF4 Primary Antibody for WB - ABIN390250
Marchand, Tomkiewicz, Magne, Barouki, Garlatti: Endoplasmic reticulum stress induction of insulin-like growth factor-binding protein-1 involves ATF4. in The Journal of biological chemistry 2006
Cow (Bovine) Polyclonal ATF4 Primary Antibody for WB - ABIN2780378
Lassot, Estrabaud, Emiliani, Benkirane, Benarous, Margottin-Goguet: p300 modulates ATF4 stability and transcriptional activity independently of its acetyltransferase domain. in The Journal of biological chemistry 2005
Human Polyclonal ATF4 Primary Antibody for WB - ABIN2792651
Zhou, Palam, Jiang, Narasimhan, Staschke, Wek: Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions. in The Journal of biological chemistry 2008
Over-expression of atf4 in embryos interferes with neurogenesis and eye formation.
Unlike other CREB2 (ATF4) proteins, the ATF4 isolated from the gonads of Xenopus embryos contains a consensus phosphorylation site for protein kinase A (PKA).
PERK (show EIF2AK3 Antibodies)-eIF2alpha (show EIF2A Antibodies)-ATF4 signaling pathway mediated by endoplasmic reticulum stress involved in osteoblast differentiation of periodontal ligament cells under cyclic mechanical force.
The localization of ATF4 in the granular component of nucleoli together with its association with nascent RNA transcripts in cells undergoing proteotoxic cell stress could suggest a new function for ATF4 in cell stress management.
The results showed that the FGF21 (show FGF21 Antibodies) promoter contains three response elements for ATF4, suggesting that FGF21 (show FGF21 Antibodies) is a sensitive target of ATF4.
ADM-2 (show ADM2 Antibodies) is a stress-inducible gene controlled by ATF-4.
The results suggest that C12orf39 (show C12orf39 Antibodies), CSTA (show CSTA Antibodies), and CALCB (show CALCB Antibodies) are novel ATF4 target genes, and that C12orf39 (show C12orf39 Antibodies) promoter activity is activated by ATF4 through amino acid response element.
High ATF4 expression is associated with osteosarcoma progression.
miR (show MLXIP Antibodies)-214 directly targeted ATF4, a crucial transcriptional factor involved in anti-stress responses, down regulation of miR (show MLXIP Antibodies)-214 releases the repression of ATF4 translation and leads to increased ATF4 protein content.
The activation of ATF4 in response to ONC201 required the kinases HRI (show EIF2AK1 Antibodies) and PKR (show PKLR Antibodies), which phosphorylate and activate the translation initiation factor eIF2alpha (show EIF2A Antibodies).
TBL2 (show TBL2 Antibodies) participates in ATF4 translation through its association with the mRNA.
Inhibition or overexpression of ATF4 confirms the role of ATF4 in SESN2 (show SESN2 Antibodies) gene up-regulation induced by mitochondrial dysfunction.
Interference with DOT1L (show DOT1L Antibodies) activity resulted in transcriptional activation of Atf4 and Ddit3 (show DDIT3 Antibodies) accompanied by decreased levels of H3K79 dimethylation.
results suggest that by inducing an atypical ISR and p53 (show TP53 Antibodies)-independent apoptosis, ONC201 has clinical potential in hematological malignancies.
TFEB (show TFEB Antibodies)-regulated signaling pathway for osteoblast differentiation is involved in ATF4/CHOP (show DDIT3 Antibodies)-dependent signaling pathway.
These findings identify C/EBPgamma (show CEBPG Antibodies) as a novel antioxidant regulator and an obligatory ATF4 partner that controls redox homeostasis in normal and cancerous cells.
Gcn2 (show EIF2AK4 Antibodies) & Atf4 are involved in L-proline metabolism regulation in embryonic stem cells.
This study outlines the mechanism of NIR (show NOC2L Antibodies) laser phototoxicity and the utility of monitoring surface temperature and ATF4 expression as potential biomarkers to develop safe and effective clinical applications.
ATF4 plays a pivotal role in functional expansion and repopulating efficiency of HSCs in developing FL
results identify ursolic acid and tomatidine as potential agents and/or lead compounds for reducing ATF4 activity, weakness, and atrophy in aged skeletal muscle
The CARE-LUC mouse model represents an innovative tool to investigate the eIF2alpha (show EIF2A Antibodies)-ATF4 axis and to develop drugs targeting this important pathway in the remediation of related pathologies.
exogenous overexpression of ATF4 in breast cancer cells may facilitate the recruitment of macrophages into tumor tissues and promote tumor angiogenesis and tumor growth indirectly.
expression levels of porcine ATF4 gene were up-regulated 60 days and 120 days after birth in both breeds and the expression level in Meishan pigs was obviously higher than that in Large White pigs
Tissue transcription analysis revealed that both porcine CREB2 (show ATF2 Antibodies) and CREB3 (show CREB3 Antibodies) mRNA were ubiquitously detected in all examined tissues.
This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication.
cyclic AMP-dependent transcription factor ATF-4
, activating transcription factor 4 (tax-responsive enhancer element B67)
, cAMP-dependent transcription factor ATF-4
, activating transcription factor 4C
, activating transcription factor 4
, DNA-binding protein TAXREB67
, cAMP response element-binding protein 2
, cAMP-responsive element-binding protein 2
, cyclic AMP-responsive element-binding protein 2
, tax-responsive enhancer element B67
, tax-responsive enhancer element-binding protein 67
, c/EBP-related ATF
, tax-responsive enhancer element-binding protein 67 homolog
, taxREB67 homolog
, activating transcription factor ATF-4