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ATF6 encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Additionally we are shipping ATF6 Kits (15) and ATF6 Proteins (11) and many more products for this protein.
Showing 10 out of 169 products:
Human Monoclonal ATF6 Primary Antibody for IP, WB - ABIN2451924
Mori: Divest yourself of a preconceived idea: transcription factor ATF6 is not a soluble protein! in Molecular biology of the cell 2010
Show all 5 references for ABIN2451924
Human Monoclonal ATF6 Primary Antibody for IP, WB - ABIN2451923
Yamamoto, Sato, Matsui, Sato, Okada, Yoshida, Harada, Mori: Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1. in Developmental cell 2007
Show all 4 references for ABIN2451923
Human Polyclonal ATF6 Primary Antibody for EIA, IF - ABIN499353
Haze, Yoshida, Yanagi, Yura, Mori: Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. in Molecular biology of the cell 1999
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Human Polyclonal ATF6 Primary Antibody for EIA, IF - ABIN499351
Liu, Kaufman: The unfolded protein response. in Journal of cell science 2003
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Hamster Monoclonal ATF6 Primary Antibody for FACS, IHC - ABIN2668920
Donati, Imbriano, Mantovani: Dynamic recruitment of transcription factors and epigenetic changes on the ER stress response gene promoters. in Nucleic acids research 2006
Show all 2 references for ABIN2668920
Human Polyclonal ATF6 Primary Antibody for EIA, IHC (p) - ABIN453523
Zhu, Johansen, Prywes: Interaction of ATF6 and serum response factor. in Molecular and cellular biology 1997
Show all 2 references for ABIN453523
Human Polyclonal ATF6 Primary Antibody for FACS, IHC (p) - ABIN652625
Lee, Jin, Kang, Kim, Guthrie, Sreevalsan, Lee, Safe: The orphan nuclear receptor NR4A1 (Nur77) regulates oxidative and endoplasmic reticulum stress in pancreatic cancer cells. in Molecular cancer research : MCR 2014
Show all 2 references for ABIN652625
Human Polyclonal ATF6 Primary Antibody for WB - ABIN1105462
Thameem, Farook, Bogardus, Prochazka: Association of amino acid variants in the activating transcription factor 6 gene (ATF6) on 1q21-q23 with type 2 diabetes in Pima Indians. in Diabetes 2006
Human Polyclonal ATF6 Primary Antibody for IF (p), IHC (p) - ABIN732293
Jiang, Ren, Jiang, Wang, Zhang, Yin, Wang, Qi, Wang, Feng: Guanabenz delays the onset of disease symptoms, extends lifespan, improves motor performance and attenuates motor neuron loss in the SOD1 G93A mouse model of amyotrophic lateral sclerosis. in Neuroscience 2014
Human Polyclonal ATF6 Primary Antibody for WB - ABIN2777413
Kerbiriou, Le Drévo, Férec, Trouvé: Coupling cystic fibrosis to endoplasmic reticulum stress: Differential role of Grp78 and ATF6. in Biochimica et biophysica acta 2007
Authors observed the cleavage of ATF6, the phosphorylation of MRLC, and the expression of death-associated protein kinase (DAPK1 (show DAPK1 Antibodies)) by western blotting; the transcription of DAPK1 (show DAPK1 Antibodies) by RT-PCR; and the subcellular localization of ATF6 and mAtg9 (show ATG9A Antibodies) by immunofluorescence.
Genetic Variations in ATF6 (rs2070150) is not Associated with Hepatocellular Carcinoma in Thai Patients with Hepatitis B Virus Infection.
We found that HCS (show HLCS Antibodies) identified compounds which inhibited ATF6 nuclear translocation with high specificity, as confirmed by the luciferase reporter assay and western blot analysis
results identify a role for DREAM silencing in the activation of ATF6 signaling, which promotes early neuroprotection in HD.
Endoplasmic reticulum stress related factor ATF6 and caspase-12 (show CASP12 Antibodies) trigger apoptosis in neonatal hypoxic-ischemic encephalopathy.
Defective podocyte insulin (show INS Antibodies) signaling through p85-XBP1 (show XBP1 Antibodies) promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy.
protein expression were significantly higher in the placentas of women with early and late SPE than in the control women, whereas there were no differences in ATF6 and Ire1 (show ERN1 Antibodies) mRNA and protein.
autosomal recessive achromatopsia is caused by a frameshift mutation in ATF6 in this Pakistani family
A crucial and unexpected role for ATF6A in human foveal development and cone function.
ATF6 preferentially reduces the secretion and extracellular aggregation of destabilized, aggregation-prone variants of the amyloidogenic protein TTR (show TTR Antibodies), as compared to stable WT TTR (show TTR Antibodies) and nonamyloidogenic TTR (show TTR Antibodies) variants.
ATF6a favorably controls chondrogenesis and bone formation (1) by acting as a co-factor of Runx2 (show RUNX2 Antibodies) and enhancing Runx2 (show RUNX2 Antibodies)-incited hypertrophic chondrocyte differentiation, and (2) by affecting IHH (show IHH Antibodies) and PTHrP (show PTHLH Antibodies) signaling.
Data show that EIF2AK3/PERK (show EIF2AK3 Antibodies)-mediated downregulation of miR (show MLXIP Antibodies)-424(322)-503 cluster regulates optimal activation of IRE1 (show ERN1 Antibodies) protein and activating transcription factor 6 (ATF6) during conditions of endoplasmic reticulum stress.
Our results suggest that ATF6alpha plays an important role in neuronal survival after KA-induced excitotoxicity through the regulation of Ca(2 (show CA2 Antibodies)+) response and neuronal activity
ATF6alpha regulates the expression of endoplasmic reticulum chaperones, C/EBP homologous protein (show DDIT3 Antibodies), and ER-associated degradation components
ATF6 positively regulates chondrocyte hypertrophy and endochondral bone formation.
Defective podocyte insulin (show INS Antibodies) signaling through p85 (show ECM1 Antibodies)-XBP1 (show XBP1 Antibodies) promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy.
alpha-syn inhibited processing of ATF6 directly through physical interactions and indirectly through restricted incorporation into COPII vesicles.
DKK3 induces stem cell differentiation into smooth muscle lineage via ATF6 signaling and myocardin (show MYOCD Antibodies) expression.
The findings reveal a novel critical role of ATF6 in regulating ER stress-mediated apoptosis in chondrocyte differentiation and the molecular mechanisms involved.
Exposure of endothelial cells to VEGF (show VEGFA Antibodies), high glucose, or hydrogen peroxide up-regulated the XBP1 (show XBP1 Antibodies)/IRE1 alpha (show ERN1 Antibodies) and ATF6 arms of the unfolded protein response compared with untreated cells.
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.
activating transcription factor 6
, cyclic AMP-dependent transcription factor ATF-6 alpha-like
, cAMP-dependent transcription factor ATF-6 alpha
, cyclic AMP-dependent transcription factor ATF-6 alpha