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ATF6 encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Additionally we are shipping ATF6 Antibodies (165) and ATF6 Proteins (11) and many more products for this protein.
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Authors observed the cleavage of ATF6, the phosphorylation of MRLC, and the expression of death-associated protein kinase (DAPK1 (show DAPK1 ELISA Kits)) by western blotting; the transcription of DAPK1 (show DAPK1 ELISA Kits) by RT-PCR; and the subcellular localization of ATF6 and mAtg9 (show ATG9A ELISA Kits) by immunofluorescence.
Genetic Variations in ATF6 (rs2070150) is not Associated with Hepatocellular Carcinoma in Thai Patients with Hepatitis B Virus Infection.
We found that HCS (show HLCS ELISA Kits) identified compounds which inhibited ATF6 nuclear translocation with high specificity, as confirmed by the luciferase reporter assay and western blot analysis
results identify a role for DREAM silencing in the activation of ATF6 signaling, which promotes early neuroprotection in HD.
Endoplasmic reticulum stress related factor ATF6 and caspase-12 (show CASP12 ELISA Kits) trigger apoptosis in neonatal hypoxic-ischemic encephalopathy.
Defective podocyte insulin (show INS ELISA Kits) signaling through p85-XBP1 (show XBP1 ELISA Kits) promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy.
protein expression were significantly higher in the placentas of women with early and late SPE than in the control women, whereas there were no differences in ATF6 and Ire1 (show ERN1 ELISA Kits) mRNA and protein.
autosomal recessive achromatopsia is caused by a frameshift mutation in ATF6 in this Pakistani family
A crucial and unexpected role for ATF6A in human foveal development and cone function.
ATF6 preferentially reduces the secretion and extracellular aggregation of destabilized, aggregation-prone variants of the amyloidogenic protein TTR (show TTR ELISA Kits), as compared to stable WT TTR (show TTR ELISA Kits) and nonamyloidogenic TTR (show TTR ELISA Kits) variants.
ATF6alpha mRNA and protein levels were higher in the uterus near the implantation site following embryo implantation.
ATF6a favorably controls chondrogenesis and bone formation (1) by acting as a co-factor of Runx2 (show RUNX2 ELISA Kits) and enhancing Runx2 (show RUNX2 ELISA Kits)-incited hypertrophic chondrocyte differentiation, and (2) by affecting IHH (show IHH ELISA Kits) and PTHrP (show PTHLH ELISA Kits) signaling.
Data show that EIF2AK3/PERK (show EIF2AK3 ELISA Kits)-mediated downregulation of miR (show MLXIP ELISA Kits)-424(322)-503 cluster regulates optimal activation of IRE1 (show ERN1 ELISA Kits) protein and activating transcription factor 6 (ATF6) during conditions of endoplasmic reticulum stress.
Our results suggest that ATF6alpha plays an important role in neuronal survival after KA-induced excitotoxicity through the regulation of Ca(2 (show CA2 ELISA Kits)+) response and neuronal activity
ATF6alpha regulates the expression of endoplasmic reticulum chaperones, C/EBP homologous protein (show DDIT3 ELISA Kits), and ER-associated degradation components
ATF6 positively regulates chondrocyte hypertrophy and endochondral bone formation.
Defective podocyte insulin (show INS ELISA Kits) signaling through p85 (show ECM1 ELISA Kits)-XBP1 (show XBP1 ELISA Kits) promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy.
alpha-syn inhibited processing of ATF6 directly through physical interactions and indirectly through restricted incorporation into COPII vesicles.
DKK3 induces stem cell differentiation into smooth muscle lineage via ATF6 signaling and myocardin (show MYOCD ELISA Kits) expression.
Exposure of endothelial cells to VEGF (show VEGFA ELISA Kits), high glucose, or hydrogen peroxide up-regulated the XBP1 (show XBP1 ELISA Kits)/IRE1 alpha (show ERN1 ELISA Kits) and ATF6 arms of the unfolded protein response compared with untreated cells.
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.
activating transcription factor 6
, cyclic AMP-dependent transcription factor ATF-6 alpha-like
, cAMP-dependent transcription factor ATF-6 alpha
, cyclic AMP-dependent transcription factor ATF-6 alpha