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ATF6 encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Additionally we are shipping ATF6 Antibodies (164) and ATF6 Kits (30) and many more products for this protein.
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We found that HCS (show HLCS Proteins) identified compounds which inhibited ATF6 nuclear translocation with high specificity, as confirmed by the luciferase reporter assay and western blot analysis
results identify a role for DREAM silencing in the activation of ATF6 signaling, which promotes early neuroprotection in HD.
Endoplasmic reticulum stress related factor ATF6 and caspase-12 trigger apoptosis in neonatal hypoxic-ischemic encephalopathy.
Defective podocyte insulin (show INS Proteins) signaling through p85-XBP1 (show XBP1 Proteins) promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy.
protein expression were significantly higher in the placentas of women with early and late SPE than in the control women, whereas there were no differences in ATF6 and Ire1 (show ERN1 Proteins) mRNA and protein.
autosomal recessive achromatopsia is caused by a frameshift mutation in ATF6 in this Pakistani family
A crucial and unexpected role for ATF6A in human foveal development and cone function.
ATF6 preferentially reduces the secretion and extracellular aggregation of destabilized, aggregation-prone variants of the amyloidogenic protein TTR (show TTR Proteins), as compared to stable WT TTR (show TTR Proteins) and nonamyloidogenic TTR (show TTR Proteins) variants.
The genetic variation in ATF6 is associated with pre-diabetes and has interactive effects with BMI on pre-diabetes in the Chinese Han population.
Data show that silver nanoparticles induce activating transcription factor-6 (ATF-6) degradation, leading to activation of the NLRP-3 (show NLRP3 Proteins) inflammasome and pyroptosis.
Our results suggest that ATF6alpha plays an important role in neuronal survival after KA-induced excitotoxicity through the regulation of Ca(2 (show CA2 Proteins)+) response and neuronal activity
ATF6alpha regulates the expression of endoplasmic reticulum chaperones, C/EBP homologous protein (show DDIT3 Proteins), and ER-associated degradation components
ATF6 positively regulates chondrocyte hypertrophy and endochondral bone formation.
Defective podocyte insulin (show INS Proteins) signaling through p85 (show ECM1 Proteins)-XBP1 (show XBP1 Proteins) promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy.
alpha-syn inhibited processing of ATF6 directly through physical interactions and indirectly through restricted incorporation into COPII vesicles.
DKK3 induces stem cell differentiation into smooth muscle lineage via ATF6 signaling and myocardin expression.
The findings reveal a novel critical role of ATF6 in regulating ER stress-mediated apoptosis in chondrocyte differentiation and the molecular mechanisms involved.
data suggest ATF6alpha required for the arginine vasopressin (show AVP Proteins) neuron system to maintain water balance under dehydration
Atf6alpha is sufficient to induce the Lmf1 (show LMF1 Proteins) promoter in the absence of ER stress, and this effect is mediated by the TM-responsive cis (show CISH Proteins)-regulatory element
Exposure of endothelial cells to VEGF (show VEGFA Proteins), high glucose, or hydrogen peroxide up-regulated the XBP1 (show XBP1 Proteins)/IRE1 alpha (show ERN1 Proteins) and ATF6 arms of the unfolded protein response compared with untreated cells.
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.
activating transcription factor 6
, cyclic AMP-dependent transcription factor ATF-6 alpha-like
, cAMP-dependent transcription factor ATF-6 alpha
, cyclic AMP-dependent transcription factor ATF-6 alpha