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ACVR1B encodes an activin A type IB receptor. Additionally we are shipping Activin A Receptor Type IB Proteins (30) and Activin A Receptor Type IB Kits (5) and many more products for this protein.
Showing 10 out of 143 products:
Human Monoclonal Activin A Receptor Type IB Primary Antibody for PLA, ELISA - ABIN559768
Zhu, Xu, Cuascut, Hall, Oxford: Activin acutely sensitizes dorsal root ganglion neurons and induces hyperalgesia via PKC-mediated potentiation of transient receptor potential vanilloid I. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
Our results demonstrate that ALK4 haploinsufficiency ameliorates cardiac fibrosis and dysfunction in a mouse pressure-overload model associated with inhibition of cardiac fibroblast activation and cardiomyocyte apoptosis through the suppression of Smad2 (show SMAD2 Antibodies)/3 activity.
ALK4 is an important profibrotic signaling molecule in the post-MI CF. Haplodeficiency of ALK4 significantly improved LV function and survival rate by attenuating CF in vivo, ameliorated
Uterine Activin (show Actbeta Antibodies)-Like Kinase 4 Regulates Trophoblast Development During Mouse Placentation
These results indicate that an appropriate level of activin (show Actbeta Antibodies) signaling may be required for GSIS in pancreatic beta cells, and that activin (show Actbeta Antibodies) signaling involves modulation of KATP channel activity.
Signaling through the TGF beta (show TGFB1 Antibodies)-activin (show Actbeta Antibodies) receptors ALK4/5/7 regulates testis formation and male germ cell development.
identified ACVRIB as a direct target of miR (show MLXIP Antibodies)-145. The ectopic expression of miR (show MLXIP Antibodies)-145 reduced the levels of both ACVRIB mRNA and protein and also interfered with activin (show Actbeta Antibodies)-induced Smad2 (show SMAD2 Antibodies) phosphorylation.
Results identify a molecular mechanism that explains the cell-type specific aspects of signaling by myostatin (show MSTN Antibodies), ALK4, ALK5 (show TGFBR1 Antibodies), and other TGF-beta (show TGFB1 Antibodies) family members.
Inhibin alpha-subunit (show INHA Antibodies) N terminus interacts with activin type IB receptor to disrupt activin (show Actbeta Antibodies) signaling.
Knockdown or pharmacological inhibition of the Nodal/Activin receptor Alk4/7 in cancer stem cells virtually abrogated their self-renewal capacity and in vivo tumorigenicity
Our analysis of this Acvr1b knockout mouse line provides direct genetic evidence that Acvr1b signaling is required for both hair follicle development and cycling.
It was concluded that ALK4 inhibition increases myogenesis but also regulates the tight balance of protein synthesis and degradation.
in a relatively large cohort of athletes from Europe and South America we have shown that the ACVR1B rs2854464 A allele is associated with sprint/power performance in Caucasians but not in Brazilian athletes.
ALK4 is expressed in male germ cells and Sertoli cells.
This study demonstrated positive regulation of monocyte/macrophage differentiation by lnc-MC and uncovered an elaborate regulation mechanism composed of PU.1, lnc-MC, miR (show MLXIP Antibodies)-199a-5p, and ACVR1B.
Data suggest that activin A (show INHBA Antibodies) up-regulates SNAIL (show SNAI1 Antibodies) expression via ALK4/ACVR1B-induced SMAD (show SMAD1 Antibodies) signaling in trophoblast cells; elevated SNAIL (show SNAI1 Antibodies) contributes to up-regulation of MMP2 (show MMP2 Antibodies) expression which plays key role in promoting trophoblast cell invasion.
ACVR1B functions as a positive regulator of monocyte/macrophage differentiation. ACVR1B knockdown promoted THP-1 (show GLI2 Antibodies) proliferation by increasing Rb phosphorylation. Down-regulation reduced p-Smad2 (show SMAD2 Antibodies)/3 and C/EBPalpha (show CEBPA Antibodies), inhibiting monocyte/macrophage differentiation.
The deletion of the ACVR1B gene may mediate an aggressive cancer phenotype in pancreatic cancer.
Findings define a regulatory role of miR (show MLXIP Antibodies)-98 in tumor angiogenesis and invasion through repressed ALK4 and MMP11 (show MMP11 Antibodies) expression.
ActRIBCA signaling can promote cell migration in prostate cancer cells via a network of signaling molecules that work together to trigger the process of EMT (show ITK Antibodies), and thereby aid in the aggressiveness and progression of prostate cancers.
This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.
activin A receptor, type IB
, activin A receptor, type 1B
, activin type IB receptor
, activin receptor type-1B-like
, Activin receptor type-1B
, activin receptor IB
, activin receptor type IB
, activin receptor type-1B
, activin receptor-like kinase 4
, serine/threonine-protein kinase receptor R2
, activin A receptor, type II-like kinase 4
, Serine/threonine-protein kinase receptor R2