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Activin A Receptor, Type IIA Proteins (ACVR2A)

ACVR2A encodes activin A type II receptor. Additionally we are shipping Activin Receptor Type IIA Antibodies (99) and Activin Receptor Type IIA Kits (17) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ACVR2A 92 P27037
ACVR2A 29263 P38444
ACVR2A 11480 P27038
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Top Activin Receptor Type IIA Proteins at antibodies-online.com

Showing 10 out of 27 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human Fc Tag 100 μg Log in to see 16 Days
$250.80
Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 16 Days
$250.80
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_HEK-293 Cells Human Fc Tag 200 μg Log in to see 2 to 3 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 11 to 13 Days
$771.10
Details
HOST_Escherichia coli (E. coli) Cow His tag 100 μg Log in to see 11 to 13 Days
$785.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

ACVR2A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , , ,
, , , ,
Rat (Rattus)

Mouse (Murine) , ,
, ,

Top referenced Activin Receptor Type IIA Proteins

  1. Human Activin Receptor Type IIA Protein expressed in Human Cells - ABIN2002444 : Hildén, Tuuri, Erämaa, Ritvos: Expression of type II activin receptor genes during differentiation of human K562 cells and cDNA cloning of the human type IIB activin receptor. in Blood 1994 (PubMed)
    Show all 4 references for ABIN2002444

  2. Mouse (Murine) Activin Receptor Type IIA Protein expressed in Human Cells - ABIN2008056 : Attisano, Wrana, Montalvo, Massagué: Activation of signalling by the activin receptor complex. in Molecular and cellular biology 1996 (PubMed)
    Show all 4 references for ABIN2008056

More Proteins for Activin A Receptor, Type IIA (ACVR2A) Interaction Partners

Human Activin A Receptor, Type IIA (ACVR2A) interaction partners

  1. Data suggest ALK1 (show ACVRL1 Proteins) and ACVR2A/ACVR2B (show ACVR2B Proteins), acting as BMP9 (show GDF2 Proteins) co-receptors, rearrange pro-domains of BMP9 (show GDF2 Proteins)--pro-domain dimer complex leading to displacement of pro-domains after receptor binding, release of mature non-dimer BPM9, and activation of signaling.

  2. Activin A (show INHBA Proteins) inhibited signaling by BMP-6 (show BMP6 Proteins) and BMP-9 (show GDF2 Proteins) by competing for type 2 receptors ACVR2A and ACVR2B (show ACVR2B Proteins).

  3. Data suggest that an SNP in promoter region of ACVR2A (rs1424954, the pre-eclampsia susceptibility allele) down-regulates 1) expression of ACVR2A in trophoblasts and 2) signal transduction in response to excess activin-A (show INHBA Proteins) (as seen in pre-eclampsia).

  4. Adenomyotic tissues express high levels of myostatin, follistatin, and activin type II receptors.

  5. The gene ACVR2A was associated with the more severe early onset preeclampsia.

  6. For ACVR2A SNPs (rs10497025, rs1128919, rs13430086), no statistically significant difference was found between preeclampsia and control groups in terms of genotype and allele frequencies.

  7. ACVR2A was identified as a subnetwork component in functional association network analysis.

  8. ACVR2A showed statistically significant differential dose-expression relationship.

  9. ACVR2A interaction with Nodal and ADMP regulates head development from the 'organizer', a restricted group of cells in the embryo.

  10. This is the first report on the function of miR (show MLXIP Proteins)-195 in human placental trophoblast cells which reveals an invasion-promoting effect of the small RNA via repressing ActRIIA.

Cow (Bovine) Activin A Receptor, Type IIA (ACVR2A) interaction partners

  1. This genome-wide association study identified variants in the upstream region of ACVR2A, which were associated with female fertility in Japanese Black cattle.

Zebrafish Activin A Receptor, Type IIA (ACVR2A) interaction partners

  1. Roles in hindbrain and neural crest cell (NCC) patterning, in NCC derived pharyngeal arch cartilage and joint formation, and in tooth development.

Mouse (Murine) Activin A Receptor, Type IIA (ACVR2A) interaction partners

  1. Our study shows that a miR (show MLXIP Proteins)-590/Acvr2a/Rad51b (show Rad51B Proteins) signaling axis ensures the stabilization of mESCs by balancing DNA damage repair and rapid proliferation during self-renewal.

  2. Bmpr2 (show BMPR2 Proteins) and Acvr2a normally play cell-type-specific, necessary roles in organelle biogenesis and the shutdown of developmental programs and cell division.

  3. Acvr2a is a Th17 specific gene making Th17 cells distinct from other helper T cells, Th1 (show HAND1 Proteins), Th2, and Treg.

  4. stimulates expression of APRIL via the Smad3 (show SMAD3 Proteins) and ERK (show EPHB2 Proteins)/CREB (show CREB1 Proteins) pathways in macrophages

  5. Results demonstrated that BMPRII (show BMPR2 Proteins) and ActRII are the functional type II TGF-beta (show TGFB1 Proteins) receptors in BMP-9 (show GDF2 Proteins)-induced osteogenic differentiation of C3H10T1/2 cells.

  6. The coordinated activity of ActRIIA and BMPRII (show BMPR2 Proteins) receptor subunits selectively mediates the chemotactic response to BMP7 (show BMP7 Proteins).

  7. Activin type IIB(ActRIIB (show ACVR2B Proteins)) and its subfamily receptor, Activin type IIA (ActRIIA), cooperatively mediate the Gdf11 (show GDF11 Proteins) signal in patterning the axial vertebrae

  8. analysis of expression and cellular compartmentalization of the activin receptors ActRIIA, ActRIIB and ActRIB, the inhibin co-receptor (betaglycan), and activin signaling proteins Smads 2, 3 and 4, and growth regulatory role during lactation

  9. Data suggest that activin receptor II signaling is critical only for follicle-stimulating hormone homeostasis and not for gonadotrophin-releasing hormone (GnRH)biosynthesis or induction of pituitary GnRH receptor expression.

  10. Overexpression of ARIP2 enhances endocytosis of ActRIIAs; data indicate that ARIP2 is a novel factor regulating cell surface ActRIIA expression and activin function.

Activin Receptor Type IIA (ACVR2A) Protein Profile

Protein Summary

This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling\; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.

Gene names and symbols associated with ACVR2A

  • activin A receptor, type IIA (ACVR2A)
  • activin A receptor, type IIA (acvr2a)
  • activin A receptor, type IIA (LOC100224301)
  • activin A receptor, type IIA (Acvr2a)
  • activin A receptor, type IIAa (acvr2aa)
  • activin receptor IIA (Acvr2a)
  • actr2a protein
  • ACTRII protein
  • ActrIIa protein
  • Acvr2 protein
  • acvr2a protein
  • rActR-II protein
  • TactrII protein
  • wu:fa02e10 protein
  • XSTK9 protein

Protein level used designations for ACVR2A

activin receptor IIA , activin receptor type-2A , activin A receptor, type IIA , ACTR-IIA , activin receptor type IIA , type II activin receptor , activin A receptor, type II , activin receptor, type IIA , ACTRIIA , activin receptor type II , activin type 2 receptor , activin receptor IIa , etID22865.9

GENE ID SPECIES
397282 Sus scrofa
476140 Canis lupus familiaris
100216172 Xenopus (Silurana) tropicalis
100224301 Taeniopygia guttata
100583170 Nomascus leucogenys
92 Homo sapiens
29263 Rattus norvegicus
281598 Bos taurus
396324 Gallus gallus
443304 Ovis aries
399283 Xenopus laevis
553359 Danio rerio
11480 Mus musculus
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