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Activin A Receptor Type II-Like 1 Proteins (ACVRL1)

ACVRL1 encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. Additionally we are shipping ACVRL1 Antibodies (128) and ACVRL1 Kits (30) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ACVRL1 94 P37023
ACVRL1 25237 P80203
ACVRL1 11482 Q61288
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Top ACVRL1 Proteins at antibodies-online.com

Showing 10 out of 20 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human Fc Tag 100 μg Log in to see 16 Days
$250.80
Details
HOST_Human Cells Rat His tag,Fc Tag 100 μg Log in to see 16 Days
$250.80
Details
HOST_Human Cells Dog Fc Tag 100 μg Log in to see 16 Days
$250.80
Details
HOST_Human Cells Mouse His tag,Fc Tag 100 μg Log in to see 16 Days
$250.80
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HOST_HEK-293 Cells Human His tag 100 μg Log in to see 2 to 3 Days
$286.00
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HOST_Human Cells Cynomolgus Fc Tag 100 μg Log in to see 16 Days
$250.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details

ACVRL1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , , ,
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Rat (Rattus) ,
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Mouse (Murine) , ,
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Top referenced ACVRL1 Proteins

  1. Human ACVRL1 Protein expressed in Human Cells - ABIN2002005 : ten Dijke, Ichijo, Franzén, Schulz, Saras, Toyoshima, Heldin, Miyazono: Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity. in Oncogene 1993 (PubMed)
    Show all 6 references for ABIN2002005

  2. Mouse (Murine) ACVRL1 Protein expressed in Human Cells - ABIN2007514 : Wu, Chen, Huang, Xie, Guo: [Percutaneous hollow screws for treatment of the vertical sacrum longitudinal fracture]. in Zhongguo gu shang = China journal of orthopaedics and traumatology 2009 (PubMed)
    Show all 6 references for ABIN2007514

  3. Dog (Canine) ACVRL1 Protein expressed in Human Cells - ABIN2008895 : Chen, Massagué: Smad1 recognition and activation by the ALK1 group of transforming growth factor-beta family receptors. in The Journal of biological chemistry 1999 (PubMed)
    Show all 6 references for ABIN2008895

  4. Rat (Rattus) ACVRL1 Protein expressed in Human Cells - ABIN2003112 : Panchenko, Williams, Brody, Yu: Type I receptor serine-threonine kinase preferentially expressed in pulmonary blood vessels. in The American journal of physiology 1996 (PubMed)
    Show all 6 references for ABIN2003112

  5. Cynomolgus ACVRL1 Protein expressed in Human Cells - ABIN2009783 : Johnson, Berg, Baldwin, Gallione, Marondel, Yoon, Stenzel, Speer, Pericak-Vance, Diamond, Guttmacher, Jackson, Attisano, Kucherlapati, Porteous, Marchuk: Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2. in Nature genetics 1996 (PubMed)
    Show all 6 references for ABIN2009783

  6. Human ACVRL1 Protein expressed in HEK-293 Cells - ABIN2180578 : Lawlor, Read, Edelstein, Yang, Pierson, Stein, Wermer-Colan, Buj-Bello, Lachey, Seehra, Beggs: Inhibition of activin receptor type IIB increases strength and lifespan in myotubularin-deficient mice. in The American journal of pathology 2011 (PubMed)
    Show all 2 references for ABIN2180578

More Proteins for Activin A Receptor Type II-Like 1 (ACVRL1) Interaction Partners

Cow (Bovine) Activin A Receptor Type II-Like 1 (ACVRL1) interaction partners

  1. Results show that ALK5 (show TGFBR1 Proteins) and ALK1 play antagonistic roles in TGF-beta (show TGFB1 Proteins)-induced podosome formation in aortic endothelial cells.

  2. ALK1 and ALK5 are both essential for correct regulation of VEGF, and that disruption of either pathway leads to disease.

Zebrafish Activin A Receptor Type II-Like 1 (ACVRL1) interaction partners

  1. Control of Notch (show NOTCH1 Proteins) targets in arterial endothelium is context-dependent, with gene-specific and region-specific requirements for Notch (show NOTCH1 Proteins) and Alk1

  2. Blood flow is required not only for alk1 expression but also for Alk1 activity.

  3. Study demonstrate that alk1 expression requires blood flow, and despite normal levels of shear stress, some flow-responsive genes are dysregulated in alk1 mutant arterial endothelial cells.

  4. vbg encodes activin receptor-like kinase 1 (acvrl1), a TGFbeta (show TGFB1 Proteins) type I receptor that is expressed predominantly in the endothelium of the vessels that become dilated in vbg mutants.

Human Activin A Receptor Type II-Like 1 (ACVRL1) interaction partners

  1. The preponderance of ACVRL1 mutations was due to founder mutations, specifically, c.830C>A (p.Thr277Lys), which was found in 24 families from the same geographical area of Norway.

  2. Report interaction between ALK1 signaling and connexin40 in the development of arteriovenous malformations.

  3. Data suggest ALK1 and ACVR2A (show ACVR2A Proteins)/ACVR2B (show ACVR2B Proteins), acting as BMP9 (show GDF2 Proteins) co-receptors, rearrange pro-domains of BMP9 (show GDF2 Proteins)--pro-domain dimer complex leading to displacement of pro-domains after receptor binding, release of mature non-dimer BPM9, and activation of signaling.

  4. Short hairpin-mediated downregulation of either ALK5 (show TGFBR1 Proteins) or ALK1 resulted in a strong inhibition of TGFbeta (show TGFB1 Proteins)-induced chondrogenesis.

  5. This work was designed to examine the pathogenicity of 23 nucleotide variations in ACVRL1 gene detected in more than 400 Hereditary Hemorrhagic Telangiectasia syndrome patients.

  6. The ACVRL1 c.314-35A>G polymorphism is associated with organ vascular malformations in hereditary hemorrhagic telangiectasia patients with ENG (show ENG Proteins) mutations, but not in patients with ACVRL1 mutations.

  7. bone morphogenic proteins within the serum of cell culture medium are potent inducers of endothelial Hey1 (show HEY1 Proteins) and Hey2 (show HEY2 Proteins) gene expression within the first few hours after medium change

  8. endoglin (show ENG Proteins) and ALK1 have been identified as potential therapeutic targets for antibody treatment in various cancers.

  9. Mutations in ACVRL1 gene is not associated with pulmonary arterial hypertension.

  10. In chronic subdural hematomas, the expression of ALK-1 was slightly increased in the dura and markedly up-regulated in the outer membrane.

Mouse (Murine) Activin A Receptor Type II-Like 1 (ACVRL1) interaction partners

  1. Conclude that the ALK-1 receptor is involved in the control of arterial pressure. High AP of Alk1(+/-) mice is explained mainly by the sympathetic overactivation, which is probably related to the decreased number of cholinergic neurons.

  2. Report interaction between ALK1 signaling and connexin40 in the development of arteriovenous malformations.

  3. In vascular sprouting, neuropilin-1 (show NRP1 Proteins) suppresses the stalk-cell phenotype by limiting Smad2 (show SMAD2 Proteins)/3 activation through Alk1 and Alk5 (show TGFBR1 Proteins). Notch (show NOTCH1 Proteins) downregulates Nrp1 (show NRP1 Proteins), thus relieving the inhibition of Alk1 and Alk5 (show TGFBR1 Proteins), thereby driving stalk-cell behaviour.

  4. BMP9 (show GDF2 Proteins)/ALK1 augmented vasculogenesis and angiogenesis, and thereby enhanced neovascularization. Thus, we suggest that BMP9 (show GDF2 Proteins)/ALK1 may improve the efficacy of EPC (show TCF21 Proteins)-based therapies for treating ischemic diseases.

  5. BMP-9 (show GDF2 Proteins) induces vascular smooth muscle cell osteogenic differentiation and calcification via ALK1, Smad (show SMAD1 Proteins) and ALP (show CCL21A Proteins) dependent mechanisms.

  6. during development, endothelial Acvrl1 plays an essential role to regulate endothelial cell proliferation and arterial identity during angiogenesis, whilst in adult life endothelial Acvrl1 is required to maintain vascular integrity.

  7. Results show that ALK5 (show TGFBR1 Proteins) and ALK1 play antagonistic roles in TGF-beta (show TGFB1 Proteins)-induced podosome formation in aortic endothelial cells.

  8. ALK1 modulates obstruction-induced renal fibrosis by increased extracellular matrix synthesis in myofibroblasts, but without differences in myofibroblast number.

  9. the mechanisms responsible for the angiogenic imbalance and the response to anti-VEGF (show VEGFA Proteins) therapy differ between Eng (show ENG Proteins) and Alk1 heterozygous mice and raise the need for systemic monitoring of anti-angiogenic therapy effects in HHT patients.

  10. Deletion of Alk1 in endothelial cells in adult mice leads to an increased local endothelial cell proliferation during brain angiogenesis

ACVRL1 Protein Profile

Protein Summary

This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.

Gene names and symbols associated with ACVRL1

  • activin A receptor type II-like 1 (ACVRL1)
  • activin A receptor type II-like 1 (acvrl1)
  • activin A receptor type II-like 1 (Acvrl1)
  • activin A receptor, type II-like 1 (Acvrl1)
  • ACVRL1 protein
  • Acvrlk1 protein
  • AI115505 protein
  • AI427544 protein
  • ALK-1 protein
  • Alk1 protein
  • HHT protein
  • HHT2 protein
  • hm:zehn1109 protein
  • ORW2 protein
  • R-3 protein
  • R3 protein
  • SETHKIR protein
  • SKR3 protein
  • TSR-I protein
  • vgb protein
  • zehn1109 protein

Protein level used designations for ACVRL1

activin A receptor type II-like 1 , serine/threonine-protein kinase receptor R3 , serine/threonine-protein kinase receptor R3-like , activin receptor-like kinase 1 , vbg , violet beauregarde , TGF-B superfamily receptor type I , activin A receptor, type II-like kinase 1 , Activin receptor like kinase 1 , SKR3 , TSR-I , ALK-1 , activin receptor-like kinase-1

GENE ID SPECIES
451910 Pan troglodytes
534536 Bos taurus
696471 Macaca mulatta
100061313 Equus caballus
100135773 Felis catus
100482358 Ailuropoda melanoleuca
266753 Danio rerio
94 Homo sapiens
25237 Rattus norvegicus
477603 Canis lupus familiaris
100153279 Sus scrofa
100172614 Pongo abelii
11482 Mus musculus
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